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Neurological soft signs are associated with altered cerebellar-cerebral functional connectivity in schizophrenia
Cai, Xin-lu1,2,3; Wang, Yong-ming1,2,3; Wang, Yi1,4; Zhou, Han-yu1,4; Huang, Jia1,4; Wang, Ya1,4; Lui, Simon SY5,6; Moller, Arne2,3,7,8; Hung, Karen SY5; Mak, Henry KF9; Sham, Pak C6,10,11; Cheung, Eric FC5; Chan, Raymond CK1,2,3
第一作者Cai, Xin-lu
通讯作者Chan, Raymond C. K.(rckchan@psych.ac.cn)
通讯作者邮箱rckchan@psych.ac.cn
心理所单位排序1
摘要

Cerebellar dysfunction is associated with neurological soft signs (NSS), which is a promising endophenotype for schizophrenia spectrum disorders. However, the relationship between cerebellar-cerebral resting-state functional connectivity (rsFC) and NSS is largely unexplored. Moreover, both NSS and cerebellar-cerebral rsFC have been found to be correlated with negative symptoms of schizophrenia. Here, we investigated the correlations between NSS and cerebellar-cerebral rsFC, explored their relationship with negative symptoms in a main dataset, and validated the significant findings in a replication dataset. Both datasets comprised schizophrenia patients and healthy controls. In schizophrenia patients, we found positive correlations between NSS and rsFC of the cerebellum with the inferior frontal gyrus and the precuneus, and negative correlations between NSS and rsFC of the cerebellum with the inferior temporal gyrus. In healthy controls, NSS scores were positively correlated with rsFC of the cerebellum with the superior frontal gyrus and negatively correlated with rsFC between the cerebellum and the middle occipital gyrus. Cerebellar-prefrontal rsFC was also positively correlated with negative symptoms in schizophrenia patients. These findings were validated in the replication dataset. Our results suggest that the uncoupling of rsFC between the cerebellum and the cerebral cortex may underlie the expression of NSS in schizophrenia. NSS-related cerebellar-prefrontal rsFC may be a potential neural pathway for possible neural modulation to alleviate negative symptoms.

关键词neurological soft signs schizophrenia cerebellar-cerebral connectivity functional connectivity
2021-01-22
语种英语
DOI10.1093/schbul/sbaa200
发表期刊Schizophrenia Bulletin
ISSN1745-1701
卷号47期号:5页码:1-11
期刊论文类型实证研究
收录类别SCI
资助项目National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Philip K.H. Wong Foundation
出版者OXFORD UNIV PRESS
WOS关键词NEGATIVE SYMPTOMS ; COGNITIVE IMPAIRMENT ; UNAFFECTED SIBLINGS ; MOTOR ; ABNORMALITIES ; ENDOPHENOTYPES ; COORDINATION ; DYSFUNCTION ; MOVEMENTS ; DISTINCT
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000693668700024
WOS分区Q1
资助机构National Key Research and Development Programme ; Beijing Municipal Science & Technology Commission ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Philip K.H. Wong Foundation
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/39311
专题中国科学院心理健康重点实验室
健康与遗传心理学研究室
通讯作者Chan, Raymond CK
作者单位1.Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
2.Sino-Danish College, University of Chinese Academy of Sciences
3.Sino-Danish Centre for Education and Research
4.Department of Psychology, University of Chinese Academy of Sciences
5.Castle Peak Hospital
6.Department of Psychiatry, The University of Hong Kong
7.Centre of Functionally Integrative Neuroscience, Aarhus University
8.Department of Nuclear Medicine and PET Centre, Aarhus University Hospital
9.Department of Diagnostic Radiology, The University of Hong Kong
10.Center for PanorOmic Sciences, The University of Hong Kong
11.State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong
第一作者单位中国科学院心理研究所
通讯作者单位中国科学院心理研究所
推荐引用方式
GB/T 7714
Cai, Xin-lu,Wang, Yong-ming,Wang, Yi,et al. Neurological soft signs are associated with altered cerebellar-cerebral functional connectivity in schizophrenia[J]. Schizophrenia Bulletin,2021,47(5):1-11.
APA Cai, Xin-lu.,Wang, Yong-ming.,Wang, Yi.,Zhou, Han-yu.,Huang, Jia.,...&Chan, Raymond CK.(2021).Neurological soft signs are associated with altered cerebellar-cerebral functional connectivity in schizophrenia.Schizophrenia Bulletin,47(5),1-11.
MLA Cai, Xin-lu,et al."Neurological soft signs are associated with altered cerebellar-cerebral functional connectivity in schizophrenia".Schizophrenia Bulletin 47.5(2021):1-11.
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