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Neurological soft signs are associated with altered cerebellar-cerebral functional connectivity in schizophrenia
Cai, Xin-lu1,2,3; Wang, Yong-ming1,2,3; Wang, Yi1,4; Zhou, Han-yu1,4; Huang, Jia1,4; Wang, Ya1,4; Lui, Simon SY5,6; Moller, Arne2,3,7,8; Hung, Karen SY5; Mak, Henry KF9; Sham, Pak C6,10,11; Cheung, Eric FC5; Chan, Raymond CK1,2,3
First AuthorCai, Xin-lu
Correspondent Emailrckchan@psych.ac.cn
Contribution Rank1
Abstract

Cerebellar dysfunction is associated with neurological soft signs (NSS), which is a promising endophenotype for schizophrenia spectrum disorders. However, the relationship between cerebellar-cerebral resting-state functional connectivity (rsFC) and NSS is largely unexplored. Moreover, both NSS and cerebellar-cerebral rsFC have been found to be correlated with negative symptoms of schizophrenia. Here, we investigated the correlations between NSS and cerebellar-cerebral rsFC, explored their relationship with negative symptoms in a main dataset, and validated the significant findings in a replication dataset. Both datasets comprised schizophrenia patients and healthy controls. In schizophrenia patients, we found positive correlations between NSS and rsFC of the cerebellum with the inferior frontal gyrus and the precuneus, and negative correlations between NSS and rsFC of the cerebellum with the inferior temporal gyrus. In healthy controls, NSS scores were positively correlated with rsFC of the cerebellum with the superior frontal gyrus and negatively correlated with rsFC between the cerebellum and the middle occipital gyrus. Cerebellar-prefrontal rsFC was also positively correlated with negative symptoms in schizophrenia patients. These findings were validated in the replication dataset. Our results suggest that the uncoupling of rsFC between the cerebellum and the cerebral cortex may underlie the expression of NSS in schizophrenia. NSS-related cerebellar-prefrontal rsFC may be a potential neural pathway for possible neural modulation to alleviate negative symptoms.

Keywordneurological soft signs schizophrenia cerebellar-cerebral connectivity functional connectivity
2021-01-22
DOI10.1093/schbul/sbaa200
Source PublicationSchizophrenia Bulletin
ISSN1745-1701
Pages1-11
Subtype实证研究
Indexed BySCI
WoS QuartileQ1
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39311
Collection中国科学院心理健康重点实验室
健康与遗传心理学研究室
Corresponding AuthorChan, Raymond CK
Affiliation1.Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
2.Sino-Danish College, University of Chinese Academy of Sciences
3.Sino-Danish Centre for Education and Research
4.Department of Psychology, University of Chinese Academy of Sciences
5.Castle Peak Hospital
6.Department of Psychiatry, The University of Hong Kong
7.Centre of Functionally Integrative Neuroscience, Aarhus University
8.Department of Nuclear Medicine and PET Centre, Aarhus University Hospital
9.Department of Diagnostic Radiology, The University of Hong Kong
10.Center for PanorOmic Sciences, The University of Hong Kong
11.State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Cai, Xin-lu,Wang, Yong-ming,Wang, Yi,et al. Neurological soft signs are associated with altered cerebellar-cerebral functional connectivity in schizophrenia[J]. Schizophrenia Bulletin,2021:1-11.
APA Cai, Xin-lu.,Wang, Yong-ming.,Wang, Yi.,Zhou, Han-yu.,Huang, Jia.,...&Chan, Raymond CK.(2021).Neurological soft signs are associated with altered cerebellar-cerebral functional connectivity in schizophrenia.Schizophrenia Bulletin,1-11.
MLA Cai, Xin-lu,et al."Neurological soft signs are associated with altered cerebellar-cerebral functional connectivity in schizophrenia".Schizophrenia Bulletin (2021):1-11.
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