Different trajectories of neurological soft signs progression between treatment-responsive and treatment-resistant schizophrenia patients

doi:10.1016/j.jpsychires.2021.05.018

	Different trajectories of neurological soft signs progression between treatment-responsive and treatment-resistant schizophrenia patients
	Lui, Simon SY 1,2; Yip, Stanley SL 1; Wang, Ya3,4 ; Hung, Karen SY 1; Ho, Karen KY 1; Tsang, Kirby CM 1; Yeung, Hera KH 1; Cheung, Eric FC 1; Chan, Raymond CK 3,4
第一作者	Lui, Simon SY
通讯作者	Lui, Simon S. Y.(lsy570@hku.hk) ; Chan, Raymond C. K.(rckchan@psych.ac.cn)
通讯作者邮箱	lsy570@hku.hk ; rckchan@psych.ac.cn
心理所单位排序	3
摘要	Schizophrenia patients exhibit subtle and non-localizing neurological abnormalities, known as neurological soft signs (NSS). Life-span evidence suggests that NSS vary along the course of schizophrenia. An association between NSS and treatment response has been proposed, suggesting that NSS reflect the underlying neuropathology development in schizophrenia. However, few studies have investigated the relationship between NSS and treatment resistance in first-episode schizophrenia patients. We conducted a longitudinal study on 52 firstepisode schizophrenia patients, who were assessed at baseline, the sixth month, and the fifth year using the abridged version of the Cambridge Neurological Inventory. The trajectories of NSS between 29 treatmentresponsive patients (with full symptomatic remission) and 23 treatment-resistant patients (who received clozapine) were compared using mixed model ANOVA. We also controlled for the effect of age and estimated IQ, using a mixed ANCOVA model. Although the two schizophrenia groups had comparable NSS at the baseline, their trajectories of NSS differed significantly. Compared with their treatment-responsive counterparts, treatmentresistant schizophrenia patients had worsening of NSS over time. Our findings support the potential utility of NSS in identifying treatment resistance in first-episode schizophrenia. Progressive worsening of NSS in treatment-resistant schizophrenia patients may reflect the development of underlying neuropathology. Further studies using large samples of treatment-resistant schizophrenia patients are needed.
关键词	Neurological soft signs Treatment resistance First-episode schizophrenia Longitudinal Clozapine
	2021
语种	英语
DOI	10.1016/j.jpsychires.2021.05.018
发表期刊	Journal of Psychiatric Research
ISSN	0022-3956
卷号	138 页码:607-614
收录类别	SCI
资助项目	Philip K.H. Wong Foundation
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	1ST-EPISODE SCHIZOPHRENIA ; RATING-SCALE ; STABILITY ; PREDICTORS ; SYMPTOMS ; STATE ; ENDOPHENOTYPES ; ABNORMALITIES ; INDIVIDUALS ; INSTRUMENT
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000658540400017
WOS分区	Q1
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/39315
专题	中国科学院心理健康重点实验室健康与遗传心理学研究室
通讯作者	Lui, Simon SY; Chan, Raymond CK
作者单位	1.Castle Peak Hospital 2.Department of Psychiatry, The University of Hong Kong 3.Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences 4.Department of Psychology, University of Chinese Academy of Sciences
通讯作者单位	中国科学院心理研究所
推荐引用方式 GB/T 7714	Lui, Simon SY,Yip, Stanley SL,Wang, Ya,et al. Different trajectories of neurological soft signs progression between treatment-responsive and treatment-resistant schizophrenia patients[J]. Journal of Psychiatric Research,2021,138:607-614.
APA	Lui, Simon SY.,Yip, Stanley SL.,Wang, Ya.,Hung, Karen SY.,Ho, Karen KY.,...&Chan, Raymond CK.(2021).Different trajectories of neurological soft signs progression between treatment-responsive and treatment-resistant schizophrenia patients.Journal of Psychiatric Research,138,607-614.
MLA	Lui, Simon SY,et al."Different trajectories of neurological soft signs progression between treatment-responsive and treatment-resistant schizophrenia patients".Journal of Psychiatric Research 138(2021):607-614.

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