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The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population
Wang, Li1,2; Zhang, Jingyi1,2; Li, Gen1,2; Cao, Chengqi1,2; Fang, Ruojiao1,2; Liu, Ping3; Luo, Shu3; Zhao, Guangyi1,2; Zhang, Yingqian1,2; Zhang, Kunlin1,2
First AuthorWang, Li
Correspondent Emailzhangkl@psych.ac.cn (zhang, kunlin)
Contribution Rank1
Abstract

The adenylate cyclase activating polypeptide 1 (pituitary) receptor (ADCYAP1R1) gene is associated with the hypothalamic-pituitary-adrenal (HPA) axis, which controls stress responses. The single-nucleotide polymorphism of ADCYAP1R1, rs2267735, has been investigated in many studies to test its association with posttraumatic stress disorder (PTSD), but the results have not been consistent. It is worth systematically exploring the role of rs2267735 in PTSD development. In this study, we analyzed rs2267735 in 1,132 trauma-exposed Chinese individuals (772 females and 360 males). We utilized the PTSD checklist for DSM-5 (PCL-5) to measure the PTSD symptoms. Then, we analyzed the main, G × E (rs2267735 × trauma exposure), and G × G (with other HPA axis gene polymorphisms) effects of rs2267735 on PTSD severity (total symptoms). There were no significant main or G × E effects (P > 0.05). The G × G ADCYAP1R1-FKBP5 interaction (rs2267735 × rs1360780) was associated with PTSD severity (beta = −1.31 and P = 0.049) based on all subjects, and the G × G ADCYAP1R1-CRHR1 interaction (rs2267735 × rs242924) was correlated with PTSD severity in men (beta = −4.72 and P = 0.023). Our study indicated that the ADCYAP1R1 polymorphism rs2267735 may affect PTSD development through diverse gene-gene interactions.

KeywordADCYAP1R1 posttraumatic stress disorder HPA axis SNP ,gene-gene interaction
2021-06-07
Language英语
DOIhttps://doi.org/10.3389/fpsyt.2021.665599
Source PublicationFrontiers in Psychiatry
Volume12Pages:1-8
Subtype实证研究
Indexed BySCI ; SSCI
WoS QuartileQ2
QuartileQ2
StatusOA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39334
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Kunlin
Affiliation1.Laboratory for Traumatic Stress Studies and Center for Genetics and BioMedical Informatics Research, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
2.Department of Psychology, University of Chinese Academy of Sciences
3.People's Hospital of Deyang City
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Li,Zhang, Jingyi,Li, Gen,et al. The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population[J]. Frontiers in Psychiatry,2021,12:1-8.
APA Wang, Li.,Zhang, Jingyi.,Li, Gen.,Cao, Chengqi.,Fang, Ruojiao.,...&Zhang, Kunlin.(2021).The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population.Frontiers in Psychiatry,12,1-8.
MLA Wang, Li,et al."The ADCYAP1R1 Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population".Frontiers in Psychiatry 12(2021):1-8.
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