PSYCH OpenIR
Distinct clinical manifestations of obsessive-compulsive disorder are associated with cortical thickness alteration
Shan, Hai-di1; Liu, Ya-fei1; Zhao, Qing1,2; Wang, Yi3,4; Wang, Yong-ming3,4,5; Cheung, Eric F.6; Chan, Raymond C.1,3,4; Wang, Zhen1,2,7
Corresponding AuthorChan, Raymond C.(rckchan2003@yahoo.com.hk) ; Wang, Zhen(wangzhen@smhc.org.cn)
AbstractBackground: Although brain structural changes have been reported in patients with obsessive-compulsive disorder (OCD), results from previous studies have been inconsistent. A growing number of studies have focused on obsessive beliefs and impulsivity which could be involved in the occurrence and maintenance of OCD symptoms. The present study aimed to examine whether there are distinct brain structural changes in patients with different OCD subgroups. Methods: Eighty-nine patients with OCD and 42 healthy controls were recruited to undergo structural magnetic resonance imaging brain scan. OCD patients were classified into subgroups according to scores of the Obsessive Belief Questionnaire (OBQ-44) and the Barratt Impulsiveness Scale (BIS-11) using cluster analysis. Group comparisons in cortical thickness and subcortical volumes between all OCD patients and healthy controls, as well as between subgroups of OCD patients and healthy controls, were carried out. Results: OCD patients with more obsessive beliefs and attentional impulsivity (OCD_OB_AT) had reduced cortical thickness at the inferior parietal gyrus, the superior and middle temporal gyrus and the insula compared with OCD patients with higher score on the non-planning impulsivity (OCD_NP, corrected p < 0.05). The whole group of OCD patients and both subgroups showed reduced cortical thickness at the superior parietal gyrus compared with controls (uncorrected p < 0.01, number of vertices > 100). Conclusion: Our results suggest that apart from distinct phenomenology, there are distinct neural correlates of different OCD subgroups based on obsessive beliefs and impulsivity. These neural correlates may have clinical significance and should be considered in future research.
KeywordObsessive-compulsive disorder cluster analysis obsessive beliefs impulsivity cortical thickness
2021-05-05
Language英语
DOI10.1177/00048674211009623
Source PublicationAUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
ISSN0004-8674
Pages11
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81671340] ; Shanghai Municipal Education Commission-Gao Feng Clinical Medicine[20161321] ; Municipal Human Resources Development Programme for Outstanding Leaders in Medical Disciplines in Shanghai[2017BR058] ; Shanghai Key Laboratory of Psychotic Disorders[13dz2260500]
PublisherSAGE PUBLICATIONS LTD
WOS KeywordGREY-MATTER ; CORTEX ; IMPULSIVENESS ; VOLUME
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000651173300001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39493
Collection中国科学院心理研究所
Corresponding AuthorChan, Raymond C.; Wang, Zhen
Affiliation1.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, 600 WanPing Nan Rd, Shanghai 20000, Peoples R China
2.Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China
3.CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Inst Psychol, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, 16 LinCui Rd, Beijing 100101, Peoples R China
5.Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England
6.Castle Peak Hosp, Hong Kong, Peoples R China
7.Shanghai Jiao Tong Univ, Inst Psychol & Behav Sci, Sch Med, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Shan, Hai-di,Liu, Ya-fei,Zhao, Qing,et al. Distinct clinical manifestations of obsessive-compulsive disorder are associated with cortical thickness alteration[J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,2021:11.
APA Shan, Hai-di.,Liu, Ya-fei.,Zhao, Qing.,Wang, Yi.,Wang, Yong-ming.,...&Wang, Zhen.(2021).Distinct clinical manifestations of obsessive-compulsive disorder are associated with cortical thickness alteration.AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY,11.
MLA Shan, Hai-di,et al."Distinct clinical manifestations of obsessive-compulsive disorder are associated with cortical thickness alteration".AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2021):11.
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