PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
杏仁中央核NMDA受体对急性吗啡依赖大鼠戒断诱发条件性位置厌恶的影响
Alternative TitleEffect of NMDA Receptor within the Central Nucleus of the Amygdala on Conditioned Place Aversion Induced by Withdrawal in Acute Morphine-dependent Rats
刘彩谊; 李勇辉; 白云静; 隋南
2008
Source Publication中国心理卫生杂志
ISSN1000-6729
Volume22Issue:2Pages:94-97
Abstract目的:研究杏仁中央核(Central nucleus of the amygdala,CeA)N-甲基-D-天冬氨酸(N-methyl-D-aspartate,NMDA)受体在纳络酮诱发急性吗啡依赖大鼠戒断性情绪反应中的作用。方法:吗啡、纳络酮间隔4小时皮下注射,通过两轮纳络酮匹配训练建立条件性位置厌恶(Conditioned place aversion,CPA),作为急性吗啡依赖戒断诱发的情绪反应模型。观察纳络酮匹配训练前CeA微量注射NMDA受体拮抗剂地卓西平(MK801)对大鼠训练后在纳络酮匹配侧停留时间的影响。结果:戒断组大鼠经过两轮训练后在纳络酮匹配侧停留时间(230.4±32.8s)比假手术组(457.6±47.8s)显著缩短(P<0.01),训练前CeA微量注射MK801大鼠在纳络酮匹配侧停留时间(447.0±51.8s)比戒断组(230.4±32.8s)显著延长(P<0.01),非戒断组大鼠(急性吗啡依赖组,未接触吗啡组)训练前CeA注射MK801训练前后在处理侧停留时间差异无显著性(P>0.05)。结论:CeA注射MK801既无奖赏效应也无厌恶效应,但能阻断CPA的建立,提示CeA的NMDA受体参与急性吗啡依赖戒断诱发的情绪反应。
Keyword吗啡依赖 急性戒断 条件性位置厌恶 杏仁中央核 N-甲基-D-天冬氨酸受体
Subject Area生理心理学/生物心理学
Indexed By中文核心期刊要目总览 ASPT来源刊 CJFD收录刊
Language中文
Funding Project国家重点基础研究发展计划(973计划,CB515404);; 国家自然科学基金重点项目(30230130);; 中科院“西部之光”人才培养计划项目资助
NoteObjective:To investigate the role of glutamate receptors (NMDA) within the CeA in the negative affective component of morphine withdrawal from acute morphine-dependent rats.Methods: The negative affective component of naloxone-precipitated withdrawal in acute morphine-dependent rats were assessed with the conditioned place aversion paradigm (CPA).Results:Compared with the sham control group, the rats in withdrawal group spent significantly less time on naloxone-paired compartment (230.4±32.8 s/457.6±47.8 s ...
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/3954
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding Author隋南
Recommended Citation
GB/T 7714
刘彩谊,李勇辉,白云静,等. 杏仁中央核NMDA受体对急性吗啡依赖大鼠戒断诱发条件性位置厌恶的影响[J]. 中国心理卫生杂志,2008,22(2):94-97.
APA 刘彩谊,李勇辉,白云静,&隋南.(2008).杏仁中央核NMDA受体对急性吗啡依赖大鼠戒断诱发条件性位置厌恶的影响.中国心理卫生杂志,22(2),94-97.
MLA 刘彩谊,et al."杏仁中央核NMDA受体对急性吗啡依赖大鼠戒断诱发条件性位置厌恶的影响".中国心理卫生杂志 22.2(2008):94-97.
Files in This Item:
File Name/Size DocType Version Access License
杏仁中央核NMDA受体对急性吗啡依赖大鼠(297KB) 限制开放--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[刘彩谊]'s Articles
[李勇辉]'s Articles
[白云静]'s Articles
Baidu academic
Similar articles in Baidu academic
[刘彩谊]'s Articles
[李勇辉]'s Articles
[白云静]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[刘彩谊]'s Articles
[李勇辉]'s Articles
[白云静]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 杏仁中央核NMDA受体对急性吗啡依赖大鼠戒断诱发条件性位置厌恶的影响.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.