|Other Abstract||The phenomenon of multi-drug abuse has become an important problem in the field of prevention and treatment. In recent years, smoking is very common among multi-substance abusers, especially among methamphetamine abusers. Although studies have found that there is a close relationship between tobacco use and the occurrence and development of drugs among multi-substance abusers. However, the research on the relationship between tobacco and methamphetamine is limited. In the study of the relationship between tobacco and alcohol, cocaine and heroin, it was found that there was a cross-clue response-induced craving model. In view of the fact that methamphetamine abusers often use methamphetamine and tobacco together, it is predicted that methamphetamine abusers also have cross-material cue response-induced craving. Therefore, this study attempts to explore the characteristics of craving induced by cross-cue response in methamphetamine smokers through behavioral experiments and questionnaires.
Studies have shown that smoking cessation intervention during the treatment of major addictive substances is beneficial to maintain the long-term intervention effect of abstinence from alcohol and illegal drugs. Studies suggest that reducing cravings for smoking may reduce cravings for other substances, thereby reducing the use of other addictive substances. Therefore, this study attempts to provide smoking cessation intervention for methamphetamine abusers, to explore whether it can effectively reduce smoking craving, and to further explore whether methamphetamine can improve the psychological craving after effectively reducing smoking craving. improve its therapeutic effect.
In study 1,through the behavioral experimental method of letting addicts smoke to verify whether smoking induces the craving of methamphetamine; through the method of questionnaire, to investigate whether addicts have a craving for smoking when using methamphetamine. The results show that smoking may increase the craving and use of methamphetamine, and the use of methamphetamine may also increase the craving and amount of smoking.
The second study examined whether the re-consolidation time window combined with nicotine immediate reduction method compared with the traditional nicotine immediate reduction method could better reduce smoking craving and improve compliance to 0.1mg low nicotine cigarettes after 5 days of intervention. To observe the response of methamphetamine cue craving while nicotine addiction memory and craving changed. The results showed that in terms of smoking craving induced by time cues, women in the memory re-consolidation-nicotine immediate reduction group had a greater decrease in smoking craving for three periods (morning, noon and after dinner) than those in the traditional nicotine immediate reduction group, and the smoking craving decreased significantly at noon, while there was no difference in men's craving for smoking among the three periods. In terms of smoking craving induced by smoking cues, women in both the nicotine immediate reduction group and the traditional nicotine immediate reduction group subjectively reported a significant decrease in craving for VR-related smoking cues. The intervention effect of memory reconsolidation-nicotine immediate reduction group was better, and there was no difference in men's desire for VR-related smoking cues. In terms of acceptance of cigarettes with very low nicotine content, after 4 days of intervention, the acceptance of 0.1mg cigarettes in the consolidation-immediate nicotine reduction group was significantly higher than that in the traditional nicotine immediate reduction group, while there was no difference in male acceptance of 0.1mg cigarettes. In terms of willingness, women in the immediate nicotine reduction group were significantly more willing to smoke 0.1mg low nicotine cigarettes in the morning than those in the traditional nicotine immediate reduction group, and there was no difference in the willingness of men to smoke 0.1mg cigarettes in the morning. In terms of mood changes before and after smoking, there was no difference between women and men on mood changes in the morning and after dinner. In terms of psychological craving induced by methamphetamine cues, there was no difference in psychological craving induced by VR-related methamphetamine cues between women and men.
In summary, methamphetamine-dependent smokers have a cross-cue-induced craving response model. In the female group, the re-consolidation-nicotine immediate reduction method achieved a better intervention effect than the traditional nicotine immediate reduction method. The results provide a new idea for clinical intervention of multi-substance abusers.|