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Electrophysiological signatures predict clinical outcomes after deep brain stimulation of the globus pallidus internus in Meige syndrome
Tian, Hong1; Zhang, Bo2,3,4; Yu, Yanbing1; Zhen, Xueke1; Zhang, Li1; Yuan, Yue1; Wang, Liang5,6
First AuthorTian, Hong
Correspondent Emailyyb5185@126.com (y. yu) ; lwang@psych.ac.cn (l. wang)
Contribution Rank5
Abstract

Objective: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) has been shown to be a safe and effective alternative therapy for ameliorating medically refractory primary Meige syndrome. However, the associations between DBS target position and surrounding electrophysiological properties as well as patients & rsquo; clinical outcomes remains largely unknown. In a large number of patients, we investigated electrophysiological features around stimulation targets and explored their roles in predicting clinical outcomes following bilateral GPi-DBS. Methods: The locations of DBS active contacts along the long axis of the GPi in a standard space were calculated and compared among three groups with different clinical outcomes. The firing rates of individual neurons within the GPi were calculated for each patient and compared across the three groups. Results: Compared with the bad group (poor clinical outcome), active contacts in the good group (good clinical outcome) and the best group (best clinical outcome) were located in the more posterior GPi. The average firing rates in the good and best groups were significantly higher than in the bad group, and this difference was pronounced within the ventral GPi. For the bad group, the average firing rates were significantly lower in the ventral than in the dorsal GPi. Conclusions: This study suggests that DBS of the posterior GPi may produce better clinical outcomes during primary Meige syndrome treatment and that higher GPi neuronal activity, particularly within the ventral part, can be used as a biomarker to guide DBS electrode implantation during surgery. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

KeywordMeige syndrome Deep brain stimulation Globus pallidus internus Neuronal activity Contact locations
2021-05-01
Language英语
DOI10.1016/j.brs.2021.04.005
Source PublicationBRAIN STIMULATION
ISSN1935-861X
Volume14Issue:3Pages:685-692
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31771255] ; National Natural Science Foundation of China[32020103009] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDB32010300] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; CAS Interdisciplinary Innovation Team[JCTD2018-07] ; Capital's Funds for Health Improvement and Research[2020-2-4061] ; Guizhou Science and Technology Plan Project (Qian Kehe platform talents)[[2017]5733-082] ; Guizhou Science and Technology Plan Project (Qian Kehe Basic)[ZK[2021] General 422] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515010785]
PublisherELSEVIER SCIENCE INC
WOS KeywordSUBTHALAMIC NUCLEUS ; PARKINSONS-DISEASE ; NEURONAL-ACTIVITY ; DYSTONIA ; BLEPHAROSPASM ; DIAGNOSIS
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:000654712000030
QuartileQ1
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39665
Collection中国科学院心理健康重点实验室
Corresponding AuthorYu, Yanbing; Wang, Liang
Affiliation1.China Japan Friendship Hosp, Dept Neurosurg, Beijing, Peoples R China
2.Zunyi Med Univ, Key Lab Brain Sci, Zunyi, Guizhou, Peoples R China
3.Zunyi Med Univ, Guizhou Key Lab Anesthesia & Organ Protect, Zunyi, Guizhou, Peoples R China
4.Chinese Acad Sci, Shenzhen Inst Adv Technol, Brain Cognit & Brain Dis Inst, Shenzhen, Peoples R China
5.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Tian, Hong,Zhang, Bo,Yu, Yanbing,et al. Electrophysiological signatures predict clinical outcomes after deep brain stimulation of the globus pallidus internus in Meige syndrome[J]. BRAIN STIMULATION,2021,14(3):685-692.
APA Tian, Hong.,Zhang, Bo.,Yu, Yanbing.,Zhen, Xueke.,Zhang, Li.,...&Wang, Liang.(2021).Electrophysiological signatures predict clinical outcomes after deep brain stimulation of the globus pallidus internus in Meige syndrome.BRAIN STIMULATION,14(3),685-692.
MLA Tian, Hong,et al."Electrophysiological signatures predict clinical outcomes after deep brain stimulation of the globus pallidus internus in Meige syndrome".BRAIN STIMULATION 14.3(2021):685-692.
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