Extensive divergence of projections to the forebrain from neurons in the paraventricular nucleus of the thalamus

doi:10.1007/s00429-021-02289-6

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	Extensive divergence of projections to the forebrain from neurons in the paraventricular nucleus of the thalamus
	Li, Sa 1; Dong, Xinwen 1,2; Kirouac, Gilbert J.1
通讯作者	Kirouac, Gilbert J.(Gilbert.Kirouac@umanitoba.ca)
摘要	Neurons in the paraventricular nucleus of the thalamus (PVT) respond to emotionally salient events and project densely to subcortical regions known to mediate adaptive behavioral responses. The areas of the forebrain most densely innervated by the PVT include striatal-like subcortical regions that consist of the shell of the nucleus accumbens (NAcSh), the dorsolateral region of the bed nucleus of the stria terminalis (BSTDL) and the lateral-capsular division of the central nucleus of the amygdala (CeL). A recent tracing experiment demonstrated that the PVT is composed of two intermixed populations of neurons that primarily project to either the dorsomedial (dmNAcSh) or ventromedial region of the NAcSh (vmNAcSh) with many of the vmNAcSh projecting neurons providing collateral innervation of the BSTDL and CeL. The present study used triple injections of the retrograde tracer cholera toxin B to provide a detailed map of the location of PVT neurons that provide collaterals to the vmNAcSh, BSTDL and CeL. These neurons were intermixed throughout the PVT and did not form uniquely localized subpopulations. An intersectional viral anterograde tracing approach was used to demonstrate that regardless of its presumed target of innervation (dmNAcSh, vmNAcSh, BSTDL, or CeL), most neurons in the PVT provide collateral innervation to a common set of forebrain regions. The paper shows that PVT-dmNAcSh projecting neurons provide the most divergent projection system and that these neurons express the immediate early gene product cFos following an aversive incident. We propose that the PVT may regulate a broad range of responses to physiological and psychological challenges by simultaneously influencing functionally diverse regions of the forebrain that include the cortex, striatal-like regions in the basal forebrain and a number of hypothalamic nuclei.
关键词	Stress Paraventricular Thalamus Collaterals Nucleus accumbens Extended amygdala Behavior
	2021-05-25
语种	英语
DOI	10.1007/s00429-021-02289-6
发表期刊	BRAIN STRUCTURE & FUNCTION
ISSN	1863-2653
页码	24
收录类别	SCI
资助项目	Canadian Institutes of Health Research (CIHR)[MOP89758]
出版者	SPRINGER HEIDELBERG
WOS关键词	PITUITARY-ADRENAL RESPONSES ; AXONAL BRANCHING PATTERNS ; CHRONICALLY STRESSED RATS ; FOS EXPRESSION ; SUCROSE-SEEKING ; ACCUMBENS ; ACTIVATION ; ANTERIOR ; BEHAVIOR ; PATHWAY
WOS研究方向	Anatomy & Morphology ; Neurosciences & Neurology
WOS类目	Anatomy & Morphology ; Neurosciences
WOS记录号	WOS:000654187800001
资助机构	Canadian Institutes of Health Research (CIHR)
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/39668
通讯作者	Kirouac, Gilbert J.
作者单位	1.Univ Manitoba, Dr Gerald Niznick Coll Dent, Rady Fac Hlth Sci, Dept Oral Biol, 780 Bannatyne Ave, Winnipeg, MB R3E 0W2, Canada 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Li, Sa,Dong, Xinwen,Kirouac, Gilbert J.. Extensive divergence of projections to the forebrain from neurons in the paraventricular nucleus of the thalamus[J]. BRAIN STRUCTURE & FUNCTION,2021:24.
APA	Li, Sa,Dong, Xinwen,&Kirouac, Gilbert J..(2021).Extensive divergence of projections to the forebrain from neurons in the paraventricular nucleus of the thalamus.BRAIN STRUCTURE & FUNCTION,24.
MLA	Li, Sa,et al."Extensive divergence of projections to the forebrain from neurons in the paraventricular nucleus of the thalamus".BRAIN STRUCTURE & FUNCTION (2021):24.