Institutional Repository of Key Laboratory of Behavioral Science, CAS
Decreased effective connectivity between insula and anterior cingulate cortex during a working memory task after prolonged sleep deprivation | |
Zhang, Liwei1; Shao, Yongcong2; Jin, Xueguang3; Cai, Xiaoping4; Du, Feng1,5 | |
第一作者 | Zhang, Liwei |
通讯作者邮箱 | duf@psych.ac.cn (f. du) |
心理所单位排序 | 1 |
摘要 | Total sleep deprivation (TSD) causes a decline in almost all cognitive domains, especially working memory. However, we do not have a clear understanding of the degree working memory is impaired under prolonged TSD, nor do we know the underlying neurophysiological mechanism. In this study, we recorded EEG data from 64 subjects while they performed a working memory task during resting wakefulness, after 24 h TSD, and after 30 h TSD. ANOVA was used to verify performance differences between 24 h and 30 h TSD in working memory tasks: (1) reaction time and accuracy hit rates, (2) P200, N200, and P300 amplitude and latency in measurements of event-related potential, as well as (3) effective connectivity strength between brain areas associated with working memory. Compared to 24 h TSD, 30 h TSD significantly decreased accuracy hit rates and induced a larger N200 difference waveform. The effective connectivity analysis showed that 30 h TSD also decreased beta frequency in effective connection strength from the right insular lobe to the left anterior cingulate cortex (ACC). Effective connection from the left ventrolateral prefrontal cortex to the left dorsolateral prefrontal cortex increased in the match condition of the 2-back task. In conclusion, 30 h TSD had a greater negative impact on working memory than 24 h TSD. This impairment of working memory is associated with decreased strength in the effective connection from the right insula to the left ACC. |
关键词 | Total sleep deprivation Working memory Event-related potential Effective connectivity |
2021-07-09 | |
语种 | 英语 |
DOI | 10.1016/j.bbr.2021.113263 |
发表期刊 | BEHAVIOURAL BRAIN RESEARCH |
ISSN | 0166-4328 |
卷号 | 409页码:11 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
出版者 | ELSEVIER |
WOS关键词 | DEFAULT MODE NETWORK ; FUNCTIONAL CONNECTIVITY ; N-BACK ; PRIMARY INSOMNIA ; PERFORMANCE ; BRAIN ; ACTIVATION ; FMRI ; EEG ; METAANALYSIS |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology |
WOS类目 | Behavioral Sciences ; Neurosciences |
WOS记录号 | WOS:000663072600011 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/39709 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Du, Feng |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Beijing Sport Univ, Dept Psychol, Beijing 100084, Peoples R China 3.Changzhou Coll Informat Technol, Coll Software & Big Data, Changzhou 213164, Peoples R China 4.PLA Army Gen Hosp, Dept Cadra Word Div 3, Beijing 100700, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
第一作者单位 | 中国科学院行为科学重点实验室 |
通讯作者单位 | 中国科学院行为科学重点实验室 |
推荐引用方式 GB/T 7714 | Zhang, Liwei,Shao, Yongcong,Jin, Xueguang,et al. Decreased effective connectivity between insula and anterior cingulate cortex during a working memory task after prolonged sleep deprivation[J]. BEHAVIOURAL BRAIN RESEARCH,2021,409:11. |
APA | Zhang, Liwei,Shao, Yongcong,Jin, Xueguang,Cai, Xiaoping,&Du, Feng.(2021).Decreased effective connectivity between insula and anterior cingulate cortex during a working memory task after prolonged sleep deprivation.BEHAVIOURAL BRAIN RESEARCH,409,11. |
MLA | Zhang, Liwei,et al."Decreased effective connectivity between insula and anterior cingulate cortex during a working memory task after prolonged sleep deprivation".BEHAVIOURAL BRAIN RESEARCH 409(2021):11. |
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