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Decreased effective connectivity between insula and anterior cingulate cortex during a working memory task after prolonged sleep deprivation
Zhang, Liwei1; Shao, Yongcong2; Jin, Xueguang3; Cai, Xiaoping4; Du, Feng1,5
First AuthorZhang, Liwei
Correspondent Emailduf@psych.ac.cn (f. du)
Contribution Rank1
Abstract

Total sleep deprivation (TSD) causes a decline in almost all cognitive domains, especially working memory. However, we do not have a clear understanding of the degree working memory is impaired under prolonged TSD, nor do we know the underlying neurophysiological mechanism. In this study, we recorded EEG data from 64 subjects while they performed a working memory task during resting wakefulness, after 24 h TSD, and after 30 h TSD. ANOVA was used to verify performance differences between 24 h and 30 h TSD in working memory tasks: (1) reaction time and accuracy hit rates, (2) P200, N200, and P300 amplitude and latency in measurements of event-related potential, as well as (3) effective connectivity strength between brain areas associated with working memory. Compared to 24 h TSD, 30 h TSD significantly decreased accuracy hit rates and induced a larger N200 difference waveform. The effective connectivity analysis showed that 30 h TSD also decreased beta frequency in effective connection strength from the right insular lobe to the left anterior cingulate cortex (ACC). Effective connection from the left ventrolateral prefrontal cortex to the left dorsolateral prefrontal cortex increased in the match condition of the 2-back task. In conclusion, 30 h TSD had a greater negative impact on working memory than 24 h TSD. This impairment of working memory is associated with decreased strength in the effective connection from the right insula to the left ACC.

KeywordTotal sleep deprivation Working memory Event-related potential Effective connectivity
2021-07-09
Language英语
DOI10.1016/j.bbr.2021.113263
Source PublicationBEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
Volume409Pages:11
Subtype实证研究
Indexed BySCI
PublisherELSEVIER
WOS KeywordDEFAULT MODE NETWORK ; FUNCTIONAL CONNECTIVITY ; N-BACK ; PRIMARY INSOMNIA ; PERFORMANCE ; BRAIN ; ACTIVATION ; FMRI ; EEG ; METAANALYSIS
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000663072600011
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39709
Collection中国科学院行为科学重点实验室
Corresponding AuthorDu, Feng
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Beijing Sport Univ, Dept Psychol, Beijing 100084, Peoples R China
3.Changzhou Coll Informat Technol, Coll Software & Big Data, Changzhou 213164, Peoples R China
4.PLA Army Gen Hosp, Dept Cadra Word Div 3, Beijing 100700, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Behavioral Science, CAS
Corresponding Author AffilicationKey Laboratory of Behavioral Science, CAS
Recommended Citation
GB/T 7714
Zhang, Liwei,Shao, Yongcong,Jin, Xueguang,et al. Decreased effective connectivity between insula and anterior cingulate cortex during a working memory task after prolonged sleep deprivation[J]. BEHAVIOURAL BRAIN RESEARCH,2021,409:11.
APA Zhang, Liwei,Shao, Yongcong,Jin, Xueguang,Cai, Xiaoping,&Du, Feng.(2021).Decreased effective connectivity between insula and anterior cingulate cortex during a working memory task after prolonged sleep deprivation.BEHAVIOURAL BRAIN RESEARCH,409,11.
MLA Zhang, Liwei,et al."Decreased effective connectivity between insula and anterior cingulate cortex during a working memory task after prolonged sleep deprivation".BEHAVIOURAL BRAIN RESEARCH 409(2021):11.
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