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Sex differences in the association between serum BDNF and cognitive impairment in schizophrenia patients using various antipsychotics
Dong, Rui1; Zhao, Ning Olivia2; Wu, Hanjing Emily2; Yu, Liling1; Zhang, Xiang Yang3,4
Correspondent Emailliling07@ccmu.edu.cn (l. yu) ; zhangxy@psych.ac.cn (x.y. zhang)
Contribution Rank3
Abstract

Background: Cognitive impairment is one of the core symptoms of schizophrenia patients. There are often various differences in the efficacy of different antipsychotics in the treatment of cognitive impairment by sex. The purpose of this study was to explore whether there are gender differences in the association between serum BDNF levels and cognitive performance in patients with schizophrenia taking different antipsychotics. Methods: We used Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to assess the cognitive function of three groups of schizophrenia patients (420 on clozapine, 183 on risperidone, 215 on typical antipsychotic drugs) and 467 healthy controls. Positive and Negative Syndrome Scale (PANSS) was used to assess schizophrenia symptoms of patients. Enzyme-Linked ImmunoSorbent Assay was used to measure serum brain-derived neurotrophic factor (BDNF) levels. Results: Among the patients taking clozapine and typical antipsychotic drugs, the RBANS total score, immediate memory, attention, and delayed memory subscores in females were higher than those in males (all p < 0.05). The RBANS total score and the delayed memory subscores in female patients taking risperidone were higher than those in male patients (all p < 0.05). Significant correlation between BDNF and cognition only existed in male patients taking clozapine, male patients taking risperidone, and male and female patients taking typical antipsychotic drugs (all p < 0.05). Conclusion: Regardless of antipsychotic effect, the cognitive function of female patients is better compared to that of male patients. For male patients, the association between BDNF and cognitive performance exists in each medication group. For female patients, this significant association was only shown in the typical antipsychotic group, but not in the clozapine and risperidone groups.

KeywordAntipsychotic drugs Schizophrenia Cognitive impairment Sex difference Brain-derived neurotrophic factor
2021-06-01
Language英语
DOI10.1016/j.jpsychires.2021.04.026
Source PublicationJOURNAL OF PSYCHIATRIC RESEARCH
ISSN0022-3956
Volume138Pages:492-499
Subtype实证研究
Indexed BySCI
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordLONG-TERM TREATMENT ; NEUROTROPHIC FACTOR ; ATYPICAL ANTIPSYCHOTICS ; REPEATABLE BATTERY ; GENDER-DIFFERENCES ; BIPOLAR DISORDER ; DECREASED BDNF ; VERBAL MEMORY ; DOUBLE-BLIND ; WEIGHT-GAIN
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000658540400002
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39719
Collection中国科学院心理健康重点实验室
Corresponding AuthorYu, Liling; Zhang, Xiang Yang
Affiliation1.Capital Med Univ, Sch Med Humanities, Dept Med Psychol, 10 Xitoutiao, Beijing 100069, Peoples R China
2.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Dong, Rui,Zhao, Ning Olivia,Wu, Hanjing Emily,et al. Sex differences in the association between serum BDNF and cognitive impairment in schizophrenia patients using various antipsychotics[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2021,138:492-499.
APA Dong, Rui,Zhao, Ning Olivia,Wu, Hanjing Emily,Yu, Liling,&Zhang, Xiang Yang.(2021).Sex differences in the association between serum BDNF and cognitive impairment in schizophrenia patients using various antipsychotics.JOURNAL OF PSYCHIATRIC RESEARCH,138,492-499.
MLA Dong, Rui,et al."Sex differences in the association between serum BDNF and cognitive impairment in schizophrenia patients using various antipsychotics".JOURNAL OF PSYCHIATRIC RESEARCH 138(2021):492-499.
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