The duration of withdrawal affects the muscarinic signaling in the nucleus accumbens after chronic morphine exposure in neonatal rats

doi:10.1152/jn.00441.2020

PSYCH OpenIR

	The duration of withdrawal affects the muscarinic signaling in the nucleus accumbens after chronic morphine exposure in neonatal rats
	Jiang, Xiao 1,2,3; Zhang, Jian-Jun 1,2; Song, Sen 4; Li, Yonghui 1,2; Sui, Nan 1,2
通讯作者	Sui, Nan(suin@psych.ac.cn)
摘要	The infants experience withdrawal from opiates, and time-dependent adaptations in neuronal activity of nucleus accumbens (NAc) may be crucial for this process. A key adaptation is an increased release of acetylcholine. The present study investigates muscarinic acetylcholine receptors (mAChRs) functions in the NAc at short-term (SWT) and long-term (LWT) withdrawal time following chronic morphine exposure in neonatal rats. The inhibitory role of presynaptic mAChRs activation in spontaneous excitatory postsynaptic currents (sEPSCs) in medium spiny neurons was decreased at LWT but not at SWT. Whereas, the excitatory role of post/extrasynaptic mAChRs activation in membrane currents was reduced at LWT but enhanced at SWT. Furthermore, the inhibitory effect of acute morphine on post/extrasynaptic mAChRs-mediated inward currents was enhanced at SWT but not at LWT. These results suggest that withdrawal from morphine leads to downregulation of presynaptic and post/extrasynaptic mAChRs functions in the NAc, which may coregulate the development of withdrawal in neonates. NEW & NOTEWORTHY We investigated for the first time how the duration of withdrawal affects mAChRs functions in the nucleus accumbens in neonatal rats. Compared with short-term withdrawal time, rats showed downregulation of presynaptic and post/extrasynaptic mAChRs functions during long-term withdrawal time. Our finding introduces a new possible correlation between the mAChRs dysfunction in the nucleus accumbens and the development of withdrawal in neonates.
关键词	medium spiny neurons (MSN) morphine withdrawal muscarinic acetylcholine receptor (mAChR) neonatal nucleus accumbens (NAc)
	2021-06-01
语种	英语
DOI	10.1152/jn.00441.2020
发表期刊	JOURNAL OF NEUROPHYSIOLOGY
ISSN	0022-3077
卷号	125 期号:6 页码:2228-2236
收录类别	SCI
资助项目	Chinese Academy of Sciences[KSCX2-EW-R-12] ; National Basic Research Program Grant[2015CB553501] ; National Natural Science Foundation[31871111] ; National Natural Science Foundation[91332115] ; Key Laboratory of Mental Health, Institute of Psychology, CAS
出版者	AMER PHYSIOLOGICAL SOC
WOS关键词	LONG-LASTING CHANGES ; MEDIUM SPINY NEURONS ; CHOLINERGIC MODULATION ; SYNAPTIC-TRANSMISSION ; ACETYLCHOLINE-RELEASE ; PLACE PREFERENCE ; MU-OPIATE ; RECEPTORS ; COCAINE ; INCUBATION
WOS研究方向	Neurosciences & Neurology ; Physiology
WOS类目	Neurosciences ; Physiology
WOS记录号	WOS:000660300600019
资助机构	Chinese Academy of Sciences ; National Basic Research Program Grant ; National Natural Science Foundation ; Key Laboratory of Mental Health, Institute of Psychology, CAS
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/39743
通讯作者	Sui, Nan
作者单位	1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Anhui Med Univ, Sch Mental Hlth & Psychol Sci, Dept Med Psychol, Hefei, Peoples R China 4.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Xiao,Zhang, Jian-Jun,Song, Sen,et al. The duration of withdrawal affects the muscarinic signaling in the nucleus accumbens after chronic morphine exposure in neonatal rats[J]. JOURNAL OF NEUROPHYSIOLOGY,2021,125(6):2228-2236.
APA	Jiang, Xiao,Zhang, Jian-Jun,Song, Sen,Li, Yonghui,&Sui, Nan.(2021).The duration of withdrawal affects the muscarinic signaling in the nucleus accumbens after chronic morphine exposure in neonatal rats.JOURNAL OF NEUROPHYSIOLOGY,125(6),2228-2236.
MLA	Jiang, Xiao,et al."The duration of withdrawal affects the muscarinic signaling in the nucleus accumbens after chronic morphine exposure in neonatal rats".JOURNAL OF NEUROPHYSIOLOGY 125.6(2021):2228-2236.