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Social brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia
Zhang, Yi-jing1,2; Pu, Cheng-cheng3; Wang, Yong-ming1,2,4,5; Zhang, Rui-ting1,2; Cai, Xin-lu1,2,4,5; Zhou, Shu-zhe3; Ma, Yan-tao3; Wang, Yi1,2; Cheung, Eric F. C.6; Lui, Simon S. Y.6,7; Yu, Xin3; Chan, Raymond C. K.1,2,4,5
First AuthorZhang, Yi-jing
Correspondent (x. yu) ; (r.c.k. chan)
Contribution Rank1

Social behaviour requires the brain to efficiently integrate multiple social processes, but it is not clear what neural substrates underlie general social behaviour. While psychosis patients and individuals with subclinical symptoms are characterized by social dysfunction, the neural mechanisms underlying social dysfunctions in schizophrenia spectrum disorders remains unclear. We first constructed a general social brain network (SBN) using resting state functional connectivity (FC) with regions of interest based on the automatic meta-analysis results from NeuroSynth. We then examined the general SBN and its relationship with social network (SN) characteristics in 30 individuals with schizophrenia (SCZ) and 33 individuals with social anhedonia (SA). We found that patients with SCZ exhibited deficits in their SN, while SA individuals did not. SCZ patients showed decreased segregation and functional connectivity in their SBN, while SA individuals showed a reversed pattern with increased segregation and functional connectivity of their SBN. Sparse canonical correlation analysis showed that both SCZ patients and SA individuals exhibited reduced correlation between SBN and SN characteristics compared with their corresponding healthy control groups. These preliminary findings suggest that both SCZ and SA participants exhibit abnormality in segregation and functional connectivity within the general SBN and reduced correlation with SN characteristics. These findings could guide the development of non-pharmacological interventions for social dysfunction in SCZ spectrum disorders. (c) 2021 Elsevier B.V. All rights reserved.

KeywordSocial brain network Social network Network analysis Schizophrenia Social anhedonia
Indexed BySCI
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for Leading Talents in ST[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000664034300013
WoS QuartileQ1
Citation statistics
Document Type期刊论文
Corresponding AuthorYu, Xin; Chan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Peking Univ, Hosp 6, Inst Mental Hlth, NHC Key Lab Mental Hlth,Natl Clin Res Ctr Mental, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
5.Sino Danish Ctr Educ & Res, Beijing, Peoples R China
6.Castle Peak Hosp, Hong Kong, Peoples R China
7.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Zhang, Yi-jing,Pu, Cheng-cheng,Wang, Yong-ming,et al. Social brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia[J]. SCHIZOPHRENIA RESEARCH,2021,232:77-84.
APA Zhang, Yi-jing.,Pu, Cheng-cheng.,Wang, Yong-ming.,Zhang, Rui-ting.,Cai, Xin-lu.,...&Chan, Raymond C. K..(2021).Social brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia.SCHIZOPHRENIA RESEARCH,232,77-84.
MLA Zhang, Yi-jing,et al."Social brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia".SCHIZOPHRENIA RESEARCH 232(2021):77-84.
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