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Association between cognitive impairment and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia
Rao, Wenwang1,2,3; Zhang, Yunshu1,4; Li, Keqing1,4; Zhang, Xiang Yang5
First AuthorRao, Wenwang
Correspondent Emailzhangxy@psych.ac.cn (x. zhang)
Contribution Rank5
Abstract

ApoE gene polymorphism may be involved in the change in blood lipid profile and cognitive impairment of the general population. However, few studies explored the effects of ApoE gene polymorphism on blood lipid levels and cognition in schizophrenia. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was employed to evaluate the cognition and the SNPStats was used to investigate the association of ApoE rs429358 with schizophrenia. The models of analysis of covariance and multivariate analysis were conducted to investigate the effect of ApoE rs429358 on cognition in schizophrenia. Altogether, 637 patients with schizophrenia and 467 healthy controls were recruited in this study. The findings in the case group found that both the ApoA1 and ApoB levels were predictors for RBANS total score (p < 0.001 vs. p = 0.011), immediate memory (p < 0.001 vs. p = 0.019), language (p < 0.001 vs. p = 0.013), attention (p < 0.001 vs. p < 0.001), except ApoA1 level only was a predictor for visuospatial/constructional (p = 0.014) and delayed memory (p < 0.001). When the association was examined in different ApoE rs429358 genotype subgroups, the association between ApoA1 level and RBANS scores (except for the language score) or between ApoB level and RBANS scores (except for the attention score) was regulated by ApoE rs429358. Our results suggest that patients with schizophrenia have broad cognitive impairment compared with healthy controls. For patients with schizophrenia, both ApoA1 and ApoB levels were positively associated with cognition. There was a significant association between ApoA1 or ApoB levels and cognition in schizophrenia, which was regulated by the ApoE rs429358.

Keywordapolipoprotein A1 apolipoprotein B apolipoprotein E cognition schizophrenia
2021-06-30
Source PublicationAGING-US
ISSN1945-4589
Volume13Issue:12Pages:16353-16366
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81371477] ; Key R&D Program of Science and Technology Department of Hebei Province[172777223] ; Government-funded Subsidy Project for Specialty Capacity-Building and Specialist Leaders[361014]
PublisherIMPACT JOURNALS LLC
WOS KeywordLOW-DENSITY-LIPOPROTEIN ; E POLYMORPHISM ; NEUROPSYCHOLOGICAL STATUS ; REPEATABLE BATTERY ; ALZHEIMERS-DISEASE ; GENE POLYMORPHISM ; YOUNG-ADULTS ; MOUSE MODEL ; APOE GENE ; EPSILON 4
WOS Research AreaCell Biology ; Geriatrics & Gerontology
WOS SubjectCell Biology ; Geriatrics & Gerontology
WOS IDWOS:000669004100015
WoS QuartileQ1
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39813
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Xiang Yang
Affiliation1.Hebei Mental Hlth Ctr, Inst Mental Hlth, Baoding, Hebei, Peoples R China
2.Univ Macau, Fac Hlth Sci, Dept Publ Hlth & Med Adm, Unit Psychiat, Macau, Peoples R China
3.Univ Macau, Fac Hlth Sci, Inst Translat Med, Macau, Peoples R China
4.Hebei Psychiat Hosp, Dept Sleep Med, Baoding, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Rao, Wenwang,Zhang, Yunshu,Li, Keqing,et al. Association between cognitive impairment and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia[J]. AGING-US,2021,13(12):16353-16366.
APA Rao, Wenwang,Zhang, Yunshu,Li, Keqing,&Zhang, Xiang Yang.(2021).Association between cognitive impairment and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia.AGING-US,13(12),16353-16366.
MLA Rao, Wenwang,et al."Association between cognitive impairment and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia".AGING-US 13.12(2021):16353-16366.
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