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Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia
Wu, Zhi Wei1,2; Yu, Hong Hua3; Wang, Xuan4; Guan, Heng Yong4; Xiu, Mei Hong5; Zhang, Xiang Yang6
Corresponding AuthorXiu, Mei Hong(xiumeihong97@163.com) ; Zhang, Xiang Yang(zhangxy9@gmail.com)
AbstractObjective Accumulating evidence has demonstrated that the pathophysiology of schizophrenia is involved in various abnormalities in oxidative stress markers and cytokines closely related to synaptic plasticity. However, the interactive effects among key cytokines, oxidative stress, and executive dysfunction and symptoms of schizophrenia have not been investigated yet. Methods A total of 189 patients with chronic schizophrenia and 60 controls were recruited in the current study. Tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, IL-6, and IL-2 levels; catalase, glutathione peroxidase, and superoxide dismutase (SOD) activities; and malondialdehyde (MDA) levels were determined in patients and controls. Executive function was evaluated by the Wisconsin card sorting tests, the verbal fluency tests, and the Stroop word-color test. Clinical symptoms were evaluated by the Positive and Negative Syndrome Scale. Results Relative to the controls, the patients had lower activities of SOD and glutathione peroxidase and levels of TNF-alpha, but higher levels of MDA, IL-8, IL-6, and IL-2 (all p values < .05). A significant negative relationship between SOD activity and IL-8 levels was found only in patients (beta = -0.44, p = .008). Furthermore, we found that an interactive effect of low TNF-alpha level and high MDA level was associated with negative symptoms (beta = -0.02, p = .01). Moreover, the interactive effects of IL-8 and MDA or IL-8 and SOD were correlated with executive function only in patients (beta = 0.23, p = .02; beta = 0.09, p = .03). Conclusions Our findings suggest that the interrelationships between oxidative stress markers and cytokines occur in schizophrenia patients, which may be the basis of their pathological mechanisms underlying clinical symptoms and cognitive dysfunction.
Keywordschizophrenia cytokine oxidative stress interactive effect clinical symptoms executive function
2021-06-01
Language英语
DOI10.1097/PSY.0000000000000931
Source PublicationPSYCHOSOMATIC MEDICINE
ISSN0033-3174
Volume83Issue:5Pages:485-491
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509] ; Shenzhen Found for Guangdong Provincial High-level Clinical Key Specialties[SZGSP013] ; Sanming Project of Medicine in Shenzhen[SZSM201812052]
PublisherLIPPINCOTT WILLIAMS & WILKINS
WOS KeywordANTIOXIDANT DEFENSE SYSTEMS ; 1ST EPISODE PSYCHOSIS ; NECROSIS-FACTOR-ALPHA ; PREFRONTAL CORTEX ; FREE-RADICALS ; CEREBROSPINAL-FLUID ; LIPID-PEROXIDATION ; NEGATIVE SYMPTOMS ; BIPOLAR DISORDER ; DOUBLE-BLIND
WOS Research AreaPsychiatry ; Psychology
WOS SubjectPsychiatry ; Psychology ; Psychology, Multidisciplinary
WOS IDWOS:000669432500012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39825
Collection中国科学院心理健康重点实验室
Corresponding AuthorXiu, Mei Hong; Zhang, Xiang Yang
Affiliation1.Shenzhen Kangning Hosp, Dept Psychiat, Shenzhen, Guangdong, Peoples R China
2.Shenzhen Mental Hlth Ctr, Shenzhen, Guangdong, Peoples R China
3.Yantai Automobile Engn Profess Coll, Yantai, Peoples R China
4.Hebei Prov Rong Jun Hosp, Dept Psychiat, Baoding, Peoples R China
5.Peking Univ, HuiLongGuan Clin Med Sch, Beijing HuiLongGuan Hosp, Psychiat Res Ctr, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wu, Zhi Wei,Yu, Hong Hua,Wang, Xuan,et al. Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia[J]. PSYCHOSOMATIC MEDICINE,2021,83(5):485-491.
APA Wu, Zhi Wei,Yu, Hong Hua,Wang, Xuan,Guan, Heng Yong,Xiu, Mei Hong,&Zhang, Xiang Yang.(2021).Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia.PSYCHOSOMATIC MEDICINE,83(5),485-491.
MLA Wu, Zhi Wei,et al."Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia".PSYCHOSOMATIC MEDICINE 83.5(2021):485-491.
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