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The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism
Jia, Haiying1; He, Mingwei2; Zhang, Xiaoyue3,4; Li, Yuling3,4; He, Shu-chang3,4; Zhang, Xiang-Yang5
第一作者Jia, Haiying
通讯作者邮箱shuchangh@pku.edu.cn (shu‑chang he ) ; zhangxy@psych.ac.cn (xiang‑yang zhang )
心理所单位排序5
摘要

Rationale Job stress can lead to job burnout, and BDNF polymorphism has been found to be involved in its psychopathological mechanism. Research needs a better understanding of the important role of gene x environment (i.e., BDNF polymorphism x job stress) interaction on job burnout. Objective This study aimed to explore how BDNF rs6265 polymorphism may moderate the relationship between job stress and job burnout. Methods Three hundred forty-one healthy participants (187 males and 154 females) from a Chinese university were included. The present study used a standardized questionnaire including demographic characteristics, job stress assessed by the House and Rizzo's Work Stress Scale, and job burnout assessed by the Maslach Burnout Inventory-General Survey. The BDNF rs6265 polymorphism was genotyped. Results Job stress showed a positive correlation with emotional exhaustion (p < 0.001), cynicism (p < 0.001), and reduced personal accomplishment (p < 0.01). The main effects of BDNF rs6265 polymorphism on emotional exhaustion and cynicism were significant [F-(1,F-333) = 5.136, p = 0.024; F-(1,F-333) = 4.175, p = 0.042, respectively]. The interaction between job stress and BDNF rs6265 on cynicism was significant (o R-2 = 0.013, p = 0.014) after controlling for age, sex, education, and position, indicating that individuals with BDNF rs6265 TT genotype showed higher level of cynicism when in high job stress. Conclusions The results provided evidence for the association of BDNF gene rs6265 polymorphism, job stress, and their interaction with job burnout. Individuals with TT genotype in BDNF rs6265 might be susceptible to stressful situations, which would lead to cynicism.

关键词Job stress Job burnout Brain-derived neurotrophic factor (BDNF) Gene-environment interaction
2021-07-10
语种英语
DOI10.1007/s00213-021-05911-x
发表期刊PSYCHOPHARMACOLOGY
ISSN0033-3158
页码9
期刊论文类型实证研究
收录类别SCI
资助项目National Natural Science Foundation of China[81871060]
出版者SPRINGER
WOS关键词FACTOR VAL66MET POLYMORPHISM ; NEUROTROPHIC FACTOR ; SERUM BDNF ; DEPRESSIVE SYMPTOMS ; SCHOOL TEACHERS ; BRAIN ; SUSCEPTIBILITY ; HEALTH ; CONFLICT ; MEMORY
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000672437900001
WOS分区Q2
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/39828
专题健康与遗传心理学研究室
通讯作者He, Shu-chang; Zhang, Xiang-Yang
作者单位1.PLA Strateg Support Force Characterist Med Ctr, Special Serv Personnel Hlth Management Dept, 9 Anxiang Beili, Beijing 100101, Peoples R China
2.Capital Med Univ, Beijing Anzhen Hosp, 2 Anzhen Rd, Beijing 100029, Peoples R China
3.Peking Univ, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
4.Peking Univ, Beijing Key Lab Behav & Mental Hlth, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
5.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
通讯作者单位中国科学院心理研究所
推荐引用方式
GB/T 7714
Jia, Haiying,He, Mingwei,Zhang, Xiaoyue,et al. The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism[J]. PSYCHOPHARMACOLOGY,2021:9.
APA Jia, Haiying,He, Mingwei,Zhang, Xiaoyue,Li, Yuling,He, Shu-chang,&Zhang, Xiang-Yang.(2021).The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism.PSYCHOPHARMACOLOGY,9.
MLA Jia, Haiying,et al."The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism".PSYCHOPHARMACOLOGY (2021):9.
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