PSYCH OpenIR  > 健康与遗传心理学研究室
The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism
Jia, Haiying1; He, Mingwei2; Zhang, Xiaoyue3,4; Li, Yuling3,4; He, Shu-chang3,4; Zhang, Xiang-Yang5
First AuthorJia, Haiying
Correspondent Emailshuchangh@pku.edu.cn (shu‑chang he ) ; zhangxy@psych.ac.cn (xiang‑yang zhang )
Contribution Rank5
Abstract

Rationale Job stress can lead to job burnout, and BDNF polymorphism has been found to be involved in its psychopathological mechanism. Research needs a better understanding of the important role of gene x environment (i.e., BDNF polymorphism x job stress) interaction on job burnout. Objective This study aimed to explore how BDNF rs6265 polymorphism may moderate the relationship between job stress and job burnout. Methods Three hundred forty-one healthy participants (187 males and 154 females) from a Chinese university were included. The present study used a standardized questionnaire including demographic characteristics, job stress assessed by the House and Rizzo's Work Stress Scale, and job burnout assessed by the Maslach Burnout Inventory-General Survey. The BDNF rs6265 polymorphism was genotyped. Results Job stress showed a positive correlation with emotional exhaustion (p < 0.001), cynicism (p < 0.001), and reduced personal accomplishment (p < 0.01). The main effects of BDNF rs6265 polymorphism on emotional exhaustion and cynicism were significant [F-(1,F-333) = 5.136, p = 0.024; F-(1,F-333) = 4.175, p = 0.042, respectively]. The interaction between job stress and BDNF rs6265 on cynicism was significant (o R-2 = 0.013, p = 0.014) after controlling for age, sex, education, and position, indicating that individuals with BDNF rs6265 TT genotype showed higher level of cynicism when in high job stress. Conclusions The results provided evidence for the association of BDNF gene rs6265 polymorphism, job stress, and their interaction with job burnout. Individuals with TT genotype in BDNF rs6265 might be susceptible to stressful situations, which would lead to cynicism.

KeywordJob stress Job burnout Brain-derived neurotrophic factor (BDNF) Gene-environment interaction
2021-07-10
Language英语
DOI10.1007/s00213-021-05911-x
Source PublicationPSYCHOPHARMACOLOGY
ISSN0033-3158
Pages9
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81871060]
PublisherSPRINGER
WOS KeywordFACTOR VAL66MET POLYMORPHISM ; NEUROTROPHIC FACTOR ; SERUM BDNF ; DEPRESSIVE SYMPTOMS ; SCHOOL TEACHERS ; BRAIN ; SUSCEPTIBILITY ; HEALTH ; CONFLICT ; MEMORY
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectNeurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000672437900001
WoS QuartileQ2
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39828
Collection健康与遗传心理学研究室
Corresponding AuthorHe, Shu-chang; Zhang, Xiang-Yang
Affiliation1.PLA Strateg Support Force Characterist Med Ctr, Special Serv Personnel Hlth Management Dept, 9 Anxiang Beili, Beijing 100101, Peoples R China
2.Capital Med Univ, Beijing Anzhen Hosp, 2 Anzhen Rd, Beijing 100029, Peoples R China
3.Peking Univ, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
4.Peking Univ, Beijing Key Lab Behav & Mental Hlth, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
5.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Jia, Haiying,He, Mingwei,Zhang, Xiaoyue,et al. The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism[J]. PSYCHOPHARMACOLOGY,2021:9.
APA Jia, Haiying,He, Mingwei,Zhang, Xiaoyue,Li, Yuling,He, Shu-chang,&Zhang, Xiang-Yang.(2021).The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism.PSYCHOPHARMACOLOGY,9.
MLA Jia, Haiying,et al."The relationship between job stress and job burnout moderated by BDNF rs6265 polymorphism".PSYCHOPHARMACOLOGY (2021):9.
Files in This Item:
File Name/Size DocType Version Access License
The relationship bet(721KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Jia, Haiying]'s Articles
[He, Mingwei]'s Articles
[Zhang, Xiaoyue]'s Articles
Baidu academic
Similar articles in Baidu academic
[Jia, Haiying]'s Articles
[He, Mingwei]'s Articles
[Zhang, Xiaoyue]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Jia, Haiying]'s Articles
[He, Mingwei]'s Articles
[Zhang, Xiaoyue]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.