Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder

doi:10.1016/j.nicl.2021.102599

PSYCH OpenIR

	Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder
	Liu, Rui 1,2; Wang, Yun 1,2; Chen, Xiongying 1,2; Zhang, Zhifang 1,2; Xiao, Le 1,2; Zhou, Yuan 1,2,3,4,5
通讯作者	Zhou, Yuan(zhouyuan@psych.ac.cn)
摘要	Background: The nucleus accumbens (NAc) is an important region in reward circuit that has been linked with anhedonia, which is a characteristic symptom of major depressive disorder (MDD). However, the relationship between the functional connectivity of the NAc subregions and anhedonia in MDD patients remains unclear. Methods: We acquired resting-state functional magnetic resonance imaging (fMRI) scans from fifty-one subjects (23 MDD patients and 28 healthy controls). We assessed subjects' trait anhedonia with the Temporal Experience of Pleasure Scale (TEPS). Seed-based resting-state functional connectivity (rsFC) was conducted for each of the NAc subregions (bilateral core-like and shell-like subdivisions) separately to identify regions whose rsFCs with the NAc subregions were altered in the MDD patients and regions whose rsFCs with the NAc subregions showed different correlates with anhedonia between the MDD patients and the healthy controls. Results: Compared with the health controls, the MDD patients showed decreased rsFCs of the right NAc core-like subdivision with the left mid-anterior orbital prefrontal cortex and the right inferior parietal lobe as well as decreased rsFC of the left NAc core-like subdivision with the right middle frontal gyrus. Moreover, the severity of anhedonia by the group interaction was significant for the rsFC of the right NAc shell-like subdivision with the subgenual/pregenual anterior cingulate cortex and the rsFC of the right NAc core-like subdivision with the precuneus. Conclusions: We found that the neural correlates of anhedonia indicated by the rsFCs of the NAc subregions were modulated by depression. The modulation effect was regionally-dependent. These findings enrich our understanding of the neural basis of anhedonia in MDD.
关键词	Anhedonia Functional connectivity Major depressive disorder Nucleus accumbens
	2021
语种	英语
DOI	10.1016/j.nicl.2021.102599
发表期刊	NEUROIMAGE-CLINICAL
ISSN	2213-1582
卷号	30 页码:10
收录类别	SCI
资助项目	National Key Research AMP; Development Program of China[2016YFC1307200] ; National Natural Science Foundation of China[81771473] ; National Natural Science Foundation of China[81901368] ; National Natural Science Foundation of China[81901372] ; Capital's Funds for Health Improvement and Research[CFH 202042125] ; Capital's Funds for Health Improvement and Research[201812121] ; State HighTech Development Plan of China (863)[2015AA020513] ; Scientific Research Project of Beijing Educational Committee[KM202010025010]
出版者	ELSEVIER SCI LTD
WOS关键词	DEEP BRAIN-STIMULATION ; INDIVIDUAL-DIFFERENCES ; ORBITOFRONTAL CORTEX ; TRAIT ANHEDONIA ; REWARD ; STATE ; PLEASURE ; SHELL ; METAANALYSIS ; ACTIVATION
WOS研究方向	Neurosciences & Neurology
WOS类目	Neuroimaging
WOS记录号	WOS:000670321800003
资助机构	National Key Research AMP; Development Program of China ; National Natural Science Foundation of China ; Capital's Funds for Health Improvement and Research ; State HighTech Development Plan of China (863) ; Scientific Research Project of Beijing Educational Committee
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/39829
通讯作者	Zhou, Yuan
作者单位	1.Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China 2.Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing 100101, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Rui,Wang, Yun,Chen, Xiongying,et al. Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder[J]. NEUROIMAGE-CLINICAL,2021,30:10.
APA	Liu, Rui,Wang, Yun,Chen, Xiongying,Zhang, Zhifang,Xiao, Le,&Zhou, Yuan.(2021).Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder.NEUROIMAGE-CLINICAL,30,10.
MLA	Liu, Rui,et al."Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder".NEUROIMAGE-CLINICAL 30(2021):10.