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Association between stereopsis deficits and attention decline in patients with major depressive disorder
Hou, Wen-long1; Yin, Xiao-li2; Yin, Xu-yuan1; Guan, Lu-yang1; Cao, Jia-qi1; Tang, Zhen1; Jiang, Cai-xia1; Xu, Dong-wu3; Yu, Xin3,4; Wang, Jing1; Jia, Qiu-fang1; Chan, Raymond C. K.5,6; Hui, Li1
First AuthorHou, Wen-long
Correspondent Emailhuili004100@126.com (l. hui)
Contribution Rank5
Abstract

Cognitive and sensory deficits were considered a core feature of major depressive disorder (MDD). However, few studies investigated stereopsis integrity in patients with MDD. Thus, the objectives of this study investigated stereopsis integrity and its correlations with cognitive function and depressive symptom in patients with MDD. 90 patients with MDD and 116 healthy controls (HCs) were enrolled in this study. Their stereoacuity was evaluated using the Titmus Stereopsis Test as well as assessing their cognitive function and depressive symptom by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Hamilton Depression Scale (HAMD). Log seconds of arc was significantly higher in patients than HCs (1.92 +/- 0.41 versus 1.67 +/- 0.16, t = 5.35, p < 0.0001). The percentage of patients with correct stereopsis detection was markedly declined in 400 (z = 3.06, p = 0.002), 200 (z = 3.84, p < 0.001), 140 (z = 4.73, p < 0.001), 100 (z = 4.58, p < 0.001), 80 (z = 5.06, p < 0.001), 60 (z = 4.72, p < 0.001), 50 (z = 4.24, p < 0.001), and 40 (z = 4.85, p < 0.001) seconds of arc compared with HCs. Log seconds of arc was significantly correlated with the RBANS total score (r = -0.38, p < 0.0001), subscores of attention (r = -0.49, p < 0.0001) and language (r = -0.33, p = 0.001) rather than HAMD score (r = 0.03, p = 0.78) in MDD patients. In addition, log seconds of arc was significantly related to the RBANS total score (r = -0.58, p < 0.0001) and language score (r = -0.45, p = 0.006) rather than attention score (r = - 0.30, p = 0.07) in HCs. Further stepwise multivariate regression analyses showed the negative correlation of log seconds of arc with attention score (13 = -0.80, t = -3.95, p < 0.0001) rather than HAMD score (13 = -0.008, t = -0.09, p = 0.93) in MDD patients. However, there was no relationship between log seconds of arc and attention score in HCs (13 = 1.52, t = 1.19, p = 0.24). Our results identified the marked deficits of stereopsis in MDD patients that were tightly correlated with their attention functioning rather than depressive symptom.

KeywordStereopsis Attention Depressive symptom Major depressive disorder Association
2021-08-30
Language英语
DOI10.1016/j.pnpbp.2021.110267
Source PublicationPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN0278-5846
Volume110Pages:6
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81771439] ; Jiangsu Provincial Key Research and Development Program[BE2020661] ; Jiangsu Provincial Key Research and Development Program[BE2018662] ; Jiangsu Provincial Health Commission Science Research Program[H2019056] ; Jiangsu Provincial Health Commission Science Research Program[LGY2018010] ; Jiangsu Provincial Six Talent Peaks Project[WSN165] ; Suzhou Municipal Health Commission Science Research Program[LCZX201820] ; Suzhou Municipal SciTech Bureau Program[SYS2019113] ; Suzhou Municipal SciTech Bureau Program[SS2019009] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2019K03] ; Sample Bank of Suzhou Municipal Psychiatric Disorders from Suzhou Municipal Finance Bureau
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordPARIETAL ; DYSFUNCTION ; 1ST-EPISODE ; PREVALENCE ; PLASTICITY ; CHILDREN ; NETWORK ; OBJECTS ; EYE
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000671082800026
WoS QuartileQ1
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39843
Collection中国科学院心理健康重点实验室
Corresponding AuthorHui, Li
Affiliation1.Soochow Univ, Affiliated Guangji Hosp, Res Ctr Biol Psychiat, 11 Guangqian Rd, Suzhou 215137, Jiangsu, Peoples R China
2.Wenzhou Med Univ, Wenzhou Kangning Hosp, Wenzhou 325007, Zhejiang, Peoples R China
3.Wenzhou Med Univ, Sch Mental Hlth, Wenzhou 325000, Zhejiang, Peoples R China
4.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
5.Mental Hlth Inst Psychiat, CAS Key Lab, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Hou, Wen-long,Yin, Xiao-li,Yin, Xu-yuan,et al. Association between stereopsis deficits and attention decline in patients with major depressive disorder[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2021,110:6.
APA Hou, Wen-long.,Yin, Xiao-li.,Yin, Xu-yuan.,Guan, Lu-yang.,Cao, Jia-qi.,...&Hui, Li.(2021).Association between stereopsis deficits and attention decline in patients with major depressive disorder.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,110,6.
MLA Hou, Wen-long,et al."Association between stereopsis deficits and attention decline in patients with major depressive disorder".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 110(2021):6.
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