Altered empathy-related resting-state functional connectivity in patients with bipolar disorder

doi:10.1007/s00406-021-01305-4

PSYCH OpenIR

	Altered empathy-related resting-state functional connectivity in patients with bipolar disorder
	Liang, Yun-si 1,2,3,4; Zhou, Shu-zhe 5,6,7,8; Zhang, Yi-jing 1,4; Cai, Xin-lu 1,2,3,4; Wang, Yi 1,4; Cheung, Eric F. C.9; Lui, Simon S. Y.9,10; Yu, Xin 5,6,7,8; Madsen, Kristoffer H.3,11,12; Ma, Yan-tao 5,6,7,8; Chan, Raymond C. K.1,2,3,4
通讯作者	Ma, Yan-tao(mayantao@bjmu.edu.cn) ; Chan, Raymond C. K.(rckchan@psych.ac.cn)
摘要	Empathy is the ability to generate emotional responses (i.e., cognitive empathy) and to make cognitive inferences (i.e., affective empathy) to other people's emotions. Empirical evidence suggests that patients with bipolar disorder (BD) exhibit impairment in cognitive empathy, but findings on affective empathy are inconsistent. Few studies have examined the neural mechanisms of cognitive and affective empathy in patients with BD. In this study, we examined the empathy-related resting-state functional connectivity (rsFC) in BD patients. Thirty-seven patients with BD and 42 healthy controls completed the self-report Questionnaires of Cognitive and Affective Empathy (QCAE), the Yoni behavioural task, and resting-sate fMRI brain scans. Group comparison of empathic ability was conducted. The interactions between group and empathic ability on seed-based whole brain rsFC were examined. BD patients scored lower on the Online Simulation subscale of the QCAE and showed positive correlations between cognitive empathy and the rsFC of the dorsal Medial Prefrontal Cortex (dmPFC) with the lingual gyrus. The correlations between cognitive empathy and the rsFC of the temporal-parietal junction (TPJ) with the fusiform gyrus, the cerebellum and the parahippocampus were weaker in BD patients than that in healthy controls. These findings highlight the underlying neural mechanisms of empathy impairments in BD patients.
关键词	Cognitive empathy Affective empathy Theory of mind Bipolar disorder Resting-state functional connectivity
	2021-07-19
语种	英语
DOI	10.1007/s00406-021-01305-4
发表期刊	EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
ISSN	0940-1334
页码	10
收录类别	SCI
资助项目	Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; Beijing Municipal Science and Technology Commission[Z171100001017086] ; National Natural Science Foundation of China[31871114] ; National Natural Science Foundation of China[31400884] ; CAS Key Laboratory of Mental Health, Institute of Psychology
出版者	SPRINGER HEIDELBERG
WOS关键词	COGNITIVE EMPATHY ; SOCIAL COGNITION ; ALE METAANALYSIS ; NEURAL-NETWORK ; RATING-SCALE ; I DISORDER ; MIND ; SCHIZOPHRENIA ; BRAIN ; QUESTIONNAIRE
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS类目	Clinical Neurology ; Psychiatry
WOS记录号	WOS:000674535600001
资助机构	Beijing Municipal Science & Technology Commission ; Beijing Training Project for the Leading Talents in Science and Technology ; Beijing Municipal Science and Technology Commission ; National Natural Science Foundation of China ; CAS Key Laboratory of Mental Health, Institute of Psychology
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/39873
通讯作者	Ma, Yan-tao; Chan, Raymond C. K.
作者单位	1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China 3.Sino Danish Ctr Educ & Res, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Peking Univ, Hosp 6, 51 Huayuan Rd, Beijing 100191, Peoples R China 6.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China 7.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China 8.Peking Univ, Natl Clin Res Ctr Mental Disorders, Hosp 6, Beijing, Peoples R China 9.Castle Peak Hosp, Hong Kong, Peoples R China 10.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China 11.Copenhagen Univ Hosp, Danish Res Ctr Magnet Resonance, Ctr Funct & Diagnost Imaging & Res, Hvidovre, Denmark 12.Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby, Denmark
推荐引用方式 GB/T 7714	Liang, Yun-si,Zhou, Shu-zhe,Zhang, Yi-jing,et al. Altered empathy-related resting-state functional connectivity in patients with bipolar disorder[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2021:10.
APA	Liang, Yun-si.,Zhou, Shu-zhe.,Zhang, Yi-jing.,Cai, Xin-lu.,Wang, Yi.,...&Chan, Raymond C. K..(2021).Altered empathy-related resting-state functional connectivity in patients with bipolar disorder.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,10.
MLA	Liang, Yun-si,et al."Altered empathy-related resting-state functional connectivity in patients with bipolar disorder".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2021):10.