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Striatal GABA level is associated with sensory integration ability in individuals with low levels of negative schizotypy
Cai, Xin-Lu1,2,3; Li, Gai-Ying4; Wang, Ling-Ling2,5; Zhao, Wei-Wei4; Wang, Yi2,5; Yan, Chao6; Lui, Simon S. Y.7; Li, Jian-Qi4; Chan, Raymond C. K.1,2,5
First AuthorCai, Xin-Lu
Correspondent Emailrckchan@psych.ac.cn
Contribution Rank2
Abstract

Recent studies suggest that altered gamma-aminobutyric acidergic (GABAergic) function may result in multisensory integration deficits in schizophrenia. However, it is unclear whether the GABA level is abnormal in individuals with high levels of schizotypal traits and how it would correlate with sensory integration ability in these individuals. This study aimed to compare the GABA level between individuals with high and low levels of negative schizotypy, and examine the relationship between GABA levels and sensory integration ability in each group. In vivo GABA+ and N-acetylaspartate (NAA) levels in the striatum were measured using proton magnetic resonance imaging in 19 participants with high levels of negative schizotypy and 21 participants with low levels of negative schizotypy. The Sensory Integration subscale of the abridged version of the Cambridge Neurological Inventory was used. We examined the group differences in GABA+/NAA levels, and the correlation between striatal GABA+/NAA levels and sensory integration ability in each group. The two groups showed comparable levels of in-vivo GABA+/NAA. In-vivo GABA+/NAA levels were negatively correlated with sensory integration score in participants with low levels of negative schizotypy, but not in participants with high levels of negative schizotypy. Our findings indicate that the increased GABA level is correlated with better sensory integration ability in individuals with low levels of negative schizotypy, implicating the role of GABAergic function in multisensory integration. Unlike schizophrenia patients, individuals with high levels of schizotypy do not exhibit any abnormality in their GABAergic system and sensory integration ability.

KeywordGABA multisensory integration proton magnetic resonance spectroscopy schizotypal traits
2021-08-19
Language英语
DOI10.1002/pchj.479
Source PublicationPSYCH JOURNAL
ISSN2046-0252
Pages10
Subtype实证研究
Indexed BySCI
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology
PublisherWILEY
WOS KeywordMAGNETIC-RESONANCE-SPECTROSCOPY ; HIGH-RISK ; MULTISENSORY INTEGRATION ; SCHIZOPHRENIA ; PSYCHOSIS ; BRAIN ; PERSONALITY ; PERCEPTION ; GLUTAMATE ; SCALES
WOS Research AreaPsychology
WOS SubjectPsychology, Multidisciplinary
WOS IDWOS:000686304200001
WoS QuartileQ3
Funding OrganizationNational Key Research and Development Programme ; Beijing Municipal Science & Technology Commission ; Beijing Training Project for the Leading Talents in Science and Technology ; CAS Key Laboratory of Mental Health, Institute of Psychology
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39973
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
2.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Sino Danish Ctr Educ & Res, Beijing, Peoples R China
4.East China Normal Univ, Sch Phys & Elect Sci, Shanghai Key Lab Magnet Resonance, Shanghai, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.East China Normal Univ, Shanghai Changning ECNU Mental Hlth Ctr, Sch Psychol & Cognit Sci, Key Lab Brain Funct Genom MOE & STCSM, Shanghai, Peoples R China
7.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Cai, Xin-Lu,Li, Gai-Ying,Wang, Ling-Ling,et al. Striatal GABA level is associated with sensory integration ability in individuals with low levels of negative schizotypy[J]. PSYCH JOURNAL,2021:10.
APA Cai, Xin-Lu.,Li, Gai-Ying.,Wang, Ling-Ling.,Zhao, Wei-Wei.,Wang, Yi.,...&Chan, Raymond C. K..(2021).Striatal GABA level is associated with sensory integration ability in individuals with low levels of negative schizotypy.PSYCH JOURNAL,10.
MLA Cai, Xin-Lu,et al."Striatal GABA level is associated with sensory integration ability in individuals with low levels of negative schizotypy".PSYCH JOURNAL (2021):10.
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