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Increased ALFF and functional connectivity of the right striatum in bipolar disorder patients
Zhang, Zhifang1,2,3,4; Bo, Qijing1,2,3,4; Li, Feng1,2,3,4; Zhao, Lei1,2,3,4; Wang, Yun1,2,3,4; Liu, Rui1,2,3,4; Chen, Xiongying1,2,3,4; Wang, Chuanyue1,2,3,4; Zhou, Yuan1,2,3,4,5,6,7
First AuthorZhang, Zhifang
Correspondent Emailzhouyuan@psych.ac.cn (y. zhou)
Contribution Rank5
Abstract

Background: Bipolar disorder (BD) is a serious neuropsychiatric disorder characterized by alternating periods of mania, depression, and euthymia. Abnormal spontaneous brain activity within the cortical-striatal neural circuits has been observed in patients with BD. However, whether the abnormality appears in patients with BD while not in a manic mood state is unclear. Methods: This study collected resting-state fMRI data from 65 patients with BD who were not in a manic mood state and 85 matched healthy controls. First, we examined differences in amplitude of low-frequency fluctuations (ALFF) between the patients with BD and the healthy controls to identify regions that show abnormal local spontaneous activity in the patients. Based on the ALFF results, we conducted seed-based resting-state functional connectivity (rsFC) analysis to identify the changes in brain networks that are centered on the regions showing abnormal local spontaneous activity in the patients. Finally, we repeated these analyses in a sub-sample comprising euthymic BD patients (N = 37) and between the euthymic BD patients and all the other patients who had at least mild depressive symptoms. Results: BD patients exhibited increased ALFF in the right caudate/putamen and increased rsFC in the right caudate/putamen with the right inferior parietal lobe (cluster-level FWE p < 0.05). Further analyses showed that the euthymic BD patients showed similar abnormalities in ALFF and rsFC maps as found in all patients with BD. And the euthymic BD patients were comparable with all the other patients who had at least mild depressive symptoms in ALFF values. Conclusions: Our results indicated the important role of the right striatum in the baseline brain function of BD patients and suggested that the abnormality of spontaneous brain activity in the cortical-striatal neural circuits may be a trait-like variant in patients with BD. The results deepen our understanding of the neurobiological mechanisms associated with BD etiology.

KeywordBipolar disorder Resting-state fMRI Amplitude of low-frequency fluctuations Functional connectivity
2021-12-20
Language英语
DOI10.1016/j.pnpbp.2020.110140
Source PublicationPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN0278-5846
Volume111Pages:8
Subtype实证研究
Indexed BySCI
Funding ProjectBeijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support[ZYLX201807] ; Beijing Municipal Natural Science Foundation[7192081] ; National Natural Science Foundation of China[81901355]
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordMAJOR DEPRESSIVE DISORDER ; LINE BRAIN ACTIVITY ; RESTING-STATE ; LOW-FREQUENCY ; GLUCOSE-METABOLISM ; SYMPTOMATIC STATUS ; DECISION-MAKING ; REWARD SYSTEM ; HEAD MOTION ; NETWORK
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000685636400016
WoS QuartileQ1
Funding OrganizationBeijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support ; Beijing Municipal Natural Science Foundation ; National Natural Science Foundation of China
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39976
Collection中国科学院行为科学重点实验室
Corresponding AuthorZhou, Yuan
Affiliation1.Capital Med Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
2.Capital Med Univ, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
4.Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
5.Chinese Acad Sci, CAS Key Lab Behav Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
6.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing 100101, Peoples R China
7.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Zhifang,Bo, Qijing,Li, Feng,et al. Increased ALFF and functional connectivity of the right striatum in bipolar disorder patients[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2021,111:8.
APA Zhang, Zhifang.,Bo, Qijing.,Li, Feng.,Zhao, Lei.,Wang, Yun.,...&Zhou, Yuan.(2021).Increased ALFF and functional connectivity of the right striatum in bipolar disorder patients.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,111,8.
MLA Zhang, Zhifang,et al."Increased ALFF and functional connectivity of the right striatum in bipolar disorder patients".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 111(2021):8.
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