Institutional Repository of Key Laboratory of Behavioral Science, CAS
Disrupted intrinsic functional brain topology in patients with major depressive disorder | |
Yang, Hong1; Chen, Xiao2,3,4; Chen, Zuo-Bing5; Li, Le6; Li, Xue-Ying2,7,8; Castellanos, Francisco Xavier9,10; Bai, Tong-Jian11; Bo, Qi-Jing12; Cao, Jun13; Chang, Zhi-Kai2,3; Chen, Guan-Mao14; Chen, Ning-Xuan2,3; Chen, Wei15; Cheng, Chang16; Cheng, Yu-Qi17; Cui, Xi-Long16; Duan, Jia18; Fang, Yiru19; Gong, Qi-Yong20,21; Guo, Wen-Bin16; Hou, Zheng-Hua22; Hu, Lan13; Kuang, Li13; Li, Feng12; Li, Hui-Xian2,3; Li, Kai-Ming20; Li, Tao23,24,25; Liu, Yan-Song26; Liu, Zhe-Ning; Long, Yi-Cheng27; Lu, Bin2,3; Luo, Qing-Hua13; Meng, Hua-Qing13; Peng, Daihui19; Qiu, Hai-Tang13; Qiu, Jiang28; Shen, Yue-Di29; Shi, Yu-Shu1; Si, Tian-Mei30,31; Tang, Yan-Qing18; Wang, Chuan-Yue12; Wang, Fei18; Wang, Kai11; Wang, Li30,31; Wang, Xiang16; Wang, Ying14; Wang, Yu-Wei2,3; Wu, Xiao-Ping30,32; Wu, Xin-Ran27; Xie, Chun-Ming31,33; Xie, Guang-Rong16; Xie, Hai-Yan34; Xie, Peng36,37; Xu, Xiu-Feng17; Yang, Jian; Yao, Jia-Shu15; Yao, Shu-Qiao16; Yin, Ying-Ying22; Yuan, Yong-Gui22; Zang, Yu-Feng38,39; Zhang, Ai-Xia40; Zhang, Hong30; Zhang, Ke-Rang40; Zhang, Lei41; Zhang, Zhi-Jun31,33; Zhao, Jing-Ping26; Zhou, Rubai19; Zhou, Yi-Ting24; Zhu, Jun-Juan42; Zhu, Zhi-Chen2,3; Zou, Chao-Jie17; Zuo, Xi-Nian43,44; Yan, Chao-Gan2,3,4,45 | |
第一作者 | Hong Yang |
摘要 | Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, we utilized a big data sample of MDD patients from the REST-meta-MDD Project, including 821 MDD patients and 765 normal controls (NCs) from 16 sites. Using the Dosenbach 160 node atlas, we examined whole-brain functional networks and extracted topological features (e.g., global and local efficiency, nodal efficiency, and degree) using graph theory-based methods. Linear mixed-effect models were used for group comparisons to control for site variability; robustness of results was confirmed (e.g., multiple topological parameters, different node definitions, and several head motion control strategies were applied). We found decreased global and local efficiency in patients with MDD compared to NCs. At the nodal level, patients with MDD were characterized by decreased nodal degrees in the somatomotor network (SMN), dorsal attention network (DAN) and visual network (VN) and decreased nodal efficiency in the default mode network (DMN), SMN, DAN, and VN. These topological differences were mostly driven by recurrent MDD patients, rather than first-episode drug naive (FEDN) patients with MDD. In this highly powered multisite study, we observed disrupted topological architecture of functional brain networks in MDD, suggesting both locally and globally decreased efficiency in brain networks. |
2021-08-12 | |
语种 | 英语 |
DOI | 10.1038/s41380-021-01247-2 |
发表期刊 | MOLECULAR PSYCHIATRY |
ISSN | 1359-4184 |
页码 | 9 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Key R&D Program of China[2017YFC1309902] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81820108018] ; National Natural Science Foundation of China[81630031] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505] ; Key Research Program of the Chinese Academy of Sciences[ZDBS-SSW-JSC006] ; Beijing Nova Program of Science and Technology[Z191100001119104] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y9CX422005] ; China Postdoctoral Science Foundation[2019M660847] ; China National Postdoctoral Program for Innovative Talents[BX20200360] ; Key Project of Science and Technology Research Plan[2020-3-016] ; Key research and development program, Ministry of Science and Technology of People's Republic of China[2019YFC0121003] ; Basic Public Welfare Research Program of Zhejiang Province[LGF20H090013] ; Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center Chinese Data-sharing Warehouse for In-vivo Imaging Brain[NBSDC-DB-15] |
出版者 | SPRINGERNATURE |
WOS关键词 | DEFAULT-MODE NETWORK ; CONNECTIVITY ; METAANALYSIS ; ABNORMALITIES ; INFORMATION ; REGIONS ; MATTER ; NAIVE |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry |
WOS类目 | Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry |
WOS记录号 | WOS:000684516400005 |
WOS分区 | Q1 |
资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China National Postdoctoral Program for Innovative Talents ; Key Project of Science and Technology Research Plan ; Key research and development program, Ministry of Science and Technology of People's Republic of China ; Basic Public Welfare Research Program of Zhejiang Province ; Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center Chinese Data-sharing Warehouse for In-vivo Imaging Brain |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/39989 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Yan, Chao-Gan |
作者单位 | 1.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Radiol, Hangzhou, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Int BigData Ctr Depress Res, Beijing, Peoples R China 5.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Rehabil Med, Hangzhou, Zhejiang, Peoples R China 6.Beijing Language & Culture Univ, Ctr Cognit Sci Language, Beijing, Peoples R China 7.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China 8.Sinodanish Ctr Educ & Res, Beijing, Peoples R China 9.NYU, Grossman Sch Med, Dept Child & Adolescent Psychiat, New York, NY 10003 USA 10.Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA 11.Anhui Med Univ, Hefei, Anhui, Peoples R China 12.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China 13.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China 14.Jinan Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China 15.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Psychiat, Hangzhou, Zhejiang, Peoples R China 16.Cent South Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China 17.Kunming Med Univ, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China 18.China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Liaoning, Peoples R China 19.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China 20.Sichuan Univ, West China Hosp, Huaxi MR Res Ctr HMRRC, Dept Radiol, Chengdu, Sichuan, Peoples R China 21.Chinese Acad Med Sci, Res Unit Psychoradiol, Chengdu, Sichuan, Peoples R China 22.Southeast Univ, Zhongda Hosp, Sch Med, Dept Psychosomat & Psychiat, Nanjing, Jiangsu, Peoples R China 23.Zhejiang Univ, Sch Med, Affiliated Mental Hlth Ctr, Hangzhou, Zhejiang, Peoples R China 24.Zhejiang Univ, Sch Med, Hangzhou Peoples Hosp 7, Hangzhou, Zhejiang, Peoples R China 25.Sichuan Univ, West China Hosp, Mental Hlth Ctr & Psychiat Lab, Chengdu, Sichuan, Peoples R China 26.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Dept Clin Psychol, Suzhou, Peoples R China 27.Cent South Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha, Hunan, Peoples R China 28.Southwest Univ, Fac Psychol, Chongqing, Peoples R China 29.Hangzhou Normal Univ, Sch Med, Affiliated Hosp, Dept Diagnost, Hangzhou, Zhejiang, Peoples R China 30.Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China 31.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China 32.Xian Cent Hosp, Xian, Shaanxi, Peoples R China 33.Southeast Univ, Affiliated ZhongDa Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China 34.Zhejiang Univ, Affiliated Hosp 4, Coll Med, Dept Psychiat, Yiwu, Zhejiang, Peoples R China 35.Chongqing Med Univ, Inst Neurosci, Chongqing, Peoples R China 36.Chongqing Key Lab Neurobiol, Chongqing, Peoples R China 37.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China 38.Hangzhou Normal Univ, Inst Psychol Sci, Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China 39.Zhejiang Key Lab Res Assessment Cognit Impairme, Hangzhou, Zhejiang, Peoples R China 40.Shanxi Med Univ, Hosp 1, Taiyuan, Shanxi, Peoples R China 41.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Lab Psychol Hlth & Imaging, Shanghai, Peoples R China 42.Shanghai Jiao Tong Univ, Sch Med, Dept Psychiat, Shanghai, Peoples R China 43.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China 44.Beijing Normal Univ, IDGMcGovern Inst Brain Res, Beijing, Peoples R China 45.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China |
通讯作者单位 | 中国科学院行为科学重点实验室 |
推荐引用方式 GB/T 7714 | Yang, Hong,Chen, Xiao,Chen, Zuo-Bing,et al. Disrupted intrinsic functional brain topology in patients with major depressive disorder[J]. MOLECULAR PSYCHIATRY,2021:9. |
APA | Yang, Hong.,Chen, Xiao.,Chen, Zuo-Bing.,Li, Le.,Li, Xue-Ying.,...&Yan, Chao-Gan.(2021).Disrupted intrinsic functional brain topology in patients with major depressive disorder.MOLECULAR PSYCHIATRY,9. |
MLA | Yang, Hong,et al."Disrupted intrinsic functional brain topology in patients with major depressive disorder".MOLECULAR PSYCHIATRY (2021):9. |
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