PSYCH OpenIR  > 中国科学院行为科学重点实验室
Disrupted intrinsic functional brain topology in patients with major depressive disorder
Yang, Hong1; Chen, Xiao2,3,4; Chen, Zuo-Bing5; Li, Le6; Li, Xue-Ying2,7,8; Castellanos, Francisco Xavier9,10; Bai, Tong-Jian11; Bo, Qi-Jing12; Cao, Jun13; Chang, Zhi-Kai2,3; Chen, Guan-Mao14; Chen, Ning-Xuan2,3; Chen, Wei15; Cheng, Chang16; Cheng, Yu-Qi17; Cui, Xi-Long16; Duan, Jia18; Fang, Yiru19; Gong, Qi-Yong20,21; Guo, Wen-Bin16; Hou, Zheng-Hua22; Hu, Lan13; Kuang, Li13; Li, Feng12; Li, Hui-Xian2,3; Li, Kai-Ming20; Li, Tao23,24,25; Liu, Yan-Song26; Liu, Zhe-Ning; Long, Yi-Cheng27; Lu, Bin2,3; Luo, Qing-Hua13; Meng, Hua-Qing13; Peng, Daihui19; Qiu, Hai-Tang13; Qiu, Jiang28; Shen, Yue-Di29; Shi, Yu-Shu1; Si, Tian-Mei30,31; Tang, Yan-Qing18; Wang, Chuan-Yue12; Wang, Fei18; Wang, Kai11; Wang, Li30,31; Wang, Xiang16; Wang, Ying14; Wang, Yu-Wei2,3; Wu, Xiao-Ping30,32; Wu, Xin-Ran27; Xie, Chun-Ming31,33; Xie, Guang-Rong16; Xie, Hai-Yan34; Xie, Peng36,37; Xu, Xiu-Feng17; Yang, Jian; Yao, Jia-Shu15; Yao, Shu-Qiao16; Yin, Ying-Ying22; Yuan, Yong-Gui22; Zang, Yu-Feng38,39; Zhang, Ai-Xia40; Zhang, Hong30; Zhang, Ke-Rang40; Zhang, Lei41; Zhang, Zhi-Jun31,33; Zhao, Jing-Ping26; Zhou, Rubai19; Zhou, Yi-Ting24; Zhu, Jun-Juan42; Zhu, Zhi-Chen2,3; Zou, Chao-Jie17; Zuo, Xi-Nian43,44; Yan, Chao-Gan2,3,4,45
Corresponding AuthorYan, Chao-Gan(ycg.yan@gmail.com)
AbstractAberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, we utilized a big data sample of MDD patients from the REST-meta-MDD Project, including 821 MDD patients and 765 normal controls (NCs) from 16 sites. Using the Dosenbach 160 node atlas, we examined whole-brain functional networks and extracted topological features (e.g., global and local efficiency, nodal efficiency, and degree) using graph theory-based methods. Linear mixed-effect models were used for group comparisons to control for site variability; robustness of results was confirmed (e.g., multiple topological parameters, different node definitions, and several head motion control strategies were applied). We found decreased global and local efficiency in patients with MDD compared to NCs. At the nodal level, patients with MDD were characterized by decreased nodal degrees in the somatomotor network (SMN), dorsal attention network (DAN) and visual network (VN) and decreased nodal efficiency in the default mode network (DMN), SMN, DAN, and VN. These topological differences were mostly driven by recurrent MDD patients, rather than first-episode drug naive (FEDN) patients with MDD. In this highly powered multisite study, we observed disrupted topological architecture of functional brain networks in MDD, suggesting both locally and globally decreased efficiency in brain networks.
2021-08-12
Language英语
DOI10.1038/s41380-021-01247-2
Source PublicationMOLECULAR PSYCHIATRY
ISSN1359-4184
Pages9
Indexed BySCI
Funding ProjectNational Key R&D Program of China[2017YFC1309902] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81820108018] ; National Natural Science Foundation of China[81630031] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505] ; Key Research Program of the Chinese Academy of Sciences[ZDBS-SSW-JSC006] ; Beijing Nova Program of Science and Technology[Z191100001119104] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y9CX422005] ; China Postdoctoral Science Foundation[2019M660847] ; China National Postdoctoral Program for Innovative Talents[BX20200360] ; Key Project of Science and Technology Research Plan[2020-3-016] ; Key research and development program, Ministry of Science and Technology of People's Republic of China[2019YFC0121003] ; Basic Public Welfare Research Program of Zhejiang Province[LGF20H090013] ; Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center Chinese Data-sharing Warehouse for In-vivo Imaging Brain[NBSDC-DB-15]
PublisherSPRINGERNATURE
WOS KeywordDEFAULT-MODE NETWORK ; CONNECTIVITY ; METAANALYSIS ; ABNORMALITIES ; INFORMATION ; REGIONS ; MATTER ; NAIVE
WOS Research AreaBiochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
WOS SubjectBiochemistry & Molecular Biology ; Neurosciences ; Psychiatry
WOS IDWOS:000684516400005
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China National Postdoctoral Program for Innovative Talents ; Key Project of Science and Technology Research Plan ; Key research and development program, Ministry of Science and Technology of People's Republic of China ; Basic Public Welfare Research Program of Zhejiang Province ; Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center Chinese Data-sharing Warehouse for In-vivo Imaging Brain
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/39989
Collection中国科学院行为科学重点实验室
Corresponding AuthorYan, Chao-Gan
Affiliation1.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Radiol, Hangzhou, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Int BigData Ctr Depress Res, Beijing, Peoples R China
5.Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Rehabil Med, Hangzhou, Zhejiang, Peoples R China
6.Beijing Language & Culture Univ, Ctr Cognit Sci Language, Beijing, Peoples R China
7.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
8.Sinodanish Ctr Educ & Res, Beijing, Peoples R China
9.NYU, Grossman Sch Med, Dept Child & Adolescent Psychiat, New York, NY 10003 USA
10.Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
11.Anhui Med Univ, Hefei, Anhui, Peoples R China
12.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
13.Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China
14.Jinan Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
15.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Psychiat, Hangzhou, Zhejiang, Peoples R China
16.Cent South Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
17.Kunming Med Univ, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China
18.China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Liaoning, Peoples R China
19.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
20.Sichuan Univ, West China Hosp, Huaxi MR Res Ctr HMRRC, Dept Radiol, Chengdu, Sichuan, Peoples R China
21.Chinese Acad Med Sci, Res Unit Psychoradiol, Chengdu, Sichuan, Peoples R China
22.Southeast Univ, Zhongda Hosp, Sch Med, Dept Psychosomat & Psychiat, Nanjing, Jiangsu, Peoples R China
23.Zhejiang Univ, Sch Med, Affiliated Mental Hlth Ctr, Hangzhou, Zhejiang, Peoples R China
24.Zhejiang Univ, Sch Med, Hangzhou Peoples Hosp 7, Hangzhou, Zhejiang, Peoples R China
25.Sichuan Univ, West China Hosp, Mental Hlth Ctr & Psychiat Lab, Chengdu, Sichuan, Peoples R China
26.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Dept Clin Psychol, Suzhou, Peoples R China
27.Cent South Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha, Hunan, Peoples R China
28.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
29.Hangzhou Normal Univ, Sch Med, Affiliated Hosp, Dept Diagnost, Hangzhou, Zhejiang, Peoples R China
30.Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
31.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China
32.Xian Cent Hosp, Xian, Shaanxi, Peoples R China
33.Southeast Univ, Affiliated ZhongDa Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China
34.Zhejiang Univ, Affiliated Hosp 4, Coll Med, Dept Psychiat, Yiwu, Zhejiang, Peoples R China
35.Chongqing Med Univ, Inst Neurosci, Chongqing, Peoples R China
36.Chongqing Key Lab Neurobiol, Chongqing, Peoples R China
37.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China
38.Hangzhou Normal Univ, Inst Psychol Sci, Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China
39.Zhejiang Key Lab Res Assessment Cognit Impairme, Hangzhou, Zhejiang, Peoples R China
40.Shanxi Med Univ, Hosp 1, Taiyuan, Shanxi, Peoples R China
41.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Lab Psychol Hlth & Imaging, Shanghai, Peoples R China
42.Shanghai Jiao Tong Univ, Sch Med, Dept Psychiat, Shanghai, Peoples R China
43.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
44.Beijing Normal Univ, IDGMcGovern Inst Brain Res, Beijing, Peoples R China
45.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Behavioral Science, CAS
Recommended Citation
GB/T 7714
Yang, Hong,Chen, Xiao,Chen, Zuo-Bing,et al. Disrupted intrinsic functional brain topology in patients with major depressive disorder[J]. MOLECULAR PSYCHIATRY,2021:9.
APA Yang, Hong.,Chen, Xiao.,Chen, Zuo-Bing.,Li, Le.,Li, Xue-Ying.,...&Yan, Chao-Gan.(2021).Disrupted intrinsic functional brain topology in patients with major depressive disorder.MOLECULAR PSYCHIATRY,9.
MLA Yang, Hong,et al."Disrupted intrinsic functional brain topology in patients with major depressive disorder".MOLECULAR PSYCHIATRY (2021):9.
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