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The brain basis of handwriting deficits in Chinese children with developmental dyslexia
Yang, Yang1,2; Zuo, Zhentao3; Tam, Fred4; Graham, Simon J.4,5; Li, Junjun1,2; Ji, Yuzhu6; Meng, Zelong7; Gu, Chanyuan8; Bi, Hong-Yan1,2; Ou, Jian9; Xu, Min9,10
第一作者YangYang
通讯作者邮箱xumin@szu.edu.cn
心理所单位排序1
摘要

Abundant behavioral studies have demonstrated high comorbidity of reading and handwriting difficulties in developmental dyslexia (DD), a neurological condition characterized by unexpectedly low reading ability despite adequate nonverbal intelligence and typical schooling. The neural correlates of handwriting deficits remain largely unknown; however, as well as the extent that handwriting deficits share common neural bases with reading deficits in DD. The present work used functional magnetic resonance imaging to examine brain activity during handwriting and reading tasks in Chinese dyslexic children (n = 18) and age-matched controls (n = 23). Compared to controls, dyslexic children exhibited reduced activation during handwriting tasks in brain regions supporting sensory-motor processing (including supplementary motor area and postcentral gyrus) and visual-orthography processing (including bilateral precuneus and right cuneus). Among these regions, the left supplementary motor area and the right precuneus also showed a trend of reduced activation during reading tasks in dyslexics. Moreover, increased activation was found in the left inferior frontal gyrus and anterior cingulate cortex in dyslexics, which may reflect more efforts of executive control to compensate for the impairments of motor and visual-orthographic processing. Finally, dyslexic children exhibited aberrant functional connectivity among brain areas for cognitive control and sensory-motor processes during handwriting tasks. Together, these findings suggest that handwriting deficits in DD are associated with functional abnormalities of multiple brain regions implicated in motor execution, visual-orthographic processing, and cognitive control, providing important implications for the diagnosis and treatment of dyslexia.

关键词brain activation developmental dyslexia fMRI functional connectivity handwriting reading
2021-08-06
语种英语
DOI10.1111/desc.13161
发表期刊DEVELOPMENTAL SCIENCE
ISSN1363-755X
页码19
期刊论文类型实证研究
收录类别SCI
资助项目National Natural Science Foundation of China[31800954] ; National Natural Science Foundation of China[31700951] ; Shenzhen Basic Research Grant[JCYJ20170412164259361] ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions[2021SHIBS0003] ; Guangdong Key Basic Research Grant[2018B030332001]
出版者WILEY
WOS关键词IMPLICIT LEARNING-DEFICITS ; ANTERIOR CINGULATE CORTEX ; FMRI CONNECTIVITY ; COLLEGE-STUDENTS ; WHOLE-BRAIN ; MOTOR ; CHARACTERS ; SYSTEM ; SKILLS ; SUPPLEMENTARY
WOS研究方向Psychology
WOS类目Psychology, Developmental ; Psychology, Experimental
WOS记录号WOS:000681614600001
资助机构National Natural Science Foundation of China ; Shenzhen Basic Research Grant ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions ; Guangdong Key Basic Research Grant
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/40052
专题中国科学院行为科学重点实验室
通讯作者Xu, Min
作者单位1.Chinese Acad Sci, Inst Psychol, Ctr Brain Sci & Learning Difficulties, CAS Key Lab Behav Sci, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
4.Sunnybrook Res Inst, Phys Sci Platform, Toronto, ON, Canada
5.Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
6.Zhejiang Univ Technol, Dept Psychol, Coll Educ, Hangzhou, Peoples R China
7.Beijing Forestry Univ, Sch Humanities & Social Sci, Dept Psychol, Beijing, Peoples R China
8.Hong Kong Polytech Univ, Fac Humanities, Dept Chinese & Bilingual Studies, Hong Kong, Peoples R China
9.Shenzhen Univ, Ctr Brain Disorders & Cognit Sci, 3688 Nanhai Ave, Shenzhen 518060, Peoples R China
10.Shenzhen Inst Neurosci, Ctr Language & Brain, Shenzhen, Peoples R China
推荐引用方式
GB/T 7714
Yang, Yang,Zuo, Zhentao,Tam, Fred,et al. The brain basis of handwriting deficits in Chinese children with developmental dyslexia[J]. DEVELOPMENTAL SCIENCE,2021:19.
APA Yang, Yang.,Zuo, Zhentao.,Tam, Fred.,Graham, Simon J..,Li, Junjun.,...&Xu, Min.(2021).The brain basis of handwriting deficits in Chinese children with developmental dyslexia.DEVELOPMENTAL SCIENCE,19.
MLA Yang, Yang,et al."The brain basis of handwriting deficits in Chinese children with developmental dyslexia".DEVELOPMENTAL SCIENCE (2021):19.
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