Institutional Repository of Key Laboratory of Behavioral Science, CAS
The brain basis of handwriting deficits in Chinese children with developmental dyslexia | |
Yang, Yang1,2; Zuo, Zhentao3; Tam, Fred4; Graham, Simon J.4,5; Li, Junjun1,2; Ji, Yuzhu6; Meng, Zelong7; Gu, Chanyuan8; Bi, Hong-Yan1,2; Ou, Jian9; Xu, Min9,10 | |
第一作者 | YangYang |
通讯作者邮箱 | xumin@szu.edu.cn |
心理所单位排序 | 1 |
摘要 | Abundant behavioral studies have demonstrated high comorbidity of reading and handwriting difficulties in developmental dyslexia (DD), a neurological condition characterized by unexpectedly low reading ability despite adequate nonverbal intelligence and typical schooling. The neural correlates of handwriting deficits remain largely unknown; however, as well as the extent that handwriting deficits share common neural bases with reading deficits in DD. The present work used functional magnetic resonance imaging to examine brain activity during handwriting and reading tasks in Chinese dyslexic children (n = 18) and age-matched controls (n = 23). Compared to controls, dyslexic children exhibited reduced activation during handwriting tasks in brain regions supporting sensory-motor processing (including supplementary motor area and postcentral gyrus) and visual-orthography processing (including bilateral precuneus and right cuneus). Among these regions, the left supplementary motor area and the right precuneus also showed a trend of reduced activation during reading tasks in dyslexics. Moreover, increased activation was found in the left inferior frontal gyrus and anterior cingulate cortex in dyslexics, which may reflect more efforts of executive control to compensate for the impairments of motor and visual-orthographic processing. Finally, dyslexic children exhibited aberrant functional connectivity among brain areas for cognitive control and sensory-motor processes during handwriting tasks. Together, these findings suggest that handwriting deficits in DD are associated with functional abnormalities of multiple brain regions implicated in motor execution, visual-orthographic processing, and cognitive control, providing important implications for the diagnosis and treatment of dyslexia. |
关键词 | brain activation developmental dyslexia fMRI functional connectivity handwriting reading |
2021-08-06 | |
语种 | 英语 |
DOI | 10.1111/desc.13161 |
发表期刊 | DEVELOPMENTAL SCIENCE |
ISSN | 1363-755X |
页码 | 19 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[31800954] ; National Natural Science Foundation of China[31700951] ; Shenzhen Basic Research Grant[JCYJ20170412164259361] ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions[2021SHIBS0003] ; Guangdong Key Basic Research Grant[2018B030332001] |
出版者 | WILEY |
WOS关键词 | IMPLICIT LEARNING-DEFICITS ; ANTERIOR CINGULATE CORTEX ; FMRI CONNECTIVITY ; COLLEGE-STUDENTS ; WHOLE-BRAIN ; MOTOR ; CHARACTERS ; SYSTEM ; SKILLS ; SUPPLEMENTARY |
WOS研究方向 | Psychology |
WOS类目 | Psychology, Developmental ; Psychology, Experimental |
WOS记录号 | WOS:000681614600001 |
资助机构 | National Natural Science Foundation of China ; Shenzhen Basic Research Grant ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions ; Guangdong Key Basic Research Grant |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/40052 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Xu, Min |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Ctr Brain Sci & Learning Difficulties, CAS Key Lab Behav Sci, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China 4.Sunnybrook Res Inst, Phys Sci Platform, Toronto, ON, Canada 5.Univ Toronto, Dept Med Biophys, Toronto, ON, Canada 6.Zhejiang Univ Technol, Dept Psychol, Coll Educ, Hangzhou, Peoples R China 7.Beijing Forestry Univ, Sch Humanities & Social Sci, Dept Psychol, Beijing, Peoples R China 8.Hong Kong Polytech Univ, Fac Humanities, Dept Chinese & Bilingual Studies, Hong Kong, Peoples R China 9.Shenzhen Univ, Ctr Brain Disorders & Cognit Sci, 3688 Nanhai Ave, Shenzhen 518060, Peoples R China 10.Shenzhen Inst Neurosci, Ctr Language & Brain, Shenzhen, Peoples R China |
推荐引用方式 GB/T 7714 | Yang, Yang,Zuo, Zhentao,Tam, Fred,et al. The brain basis of handwriting deficits in Chinese children with developmental dyslexia[J]. DEVELOPMENTAL SCIENCE,2021:19. |
APA | Yang, Yang.,Zuo, Zhentao.,Tam, Fred.,Graham, Simon J..,Li, Junjun.,...&Xu, Min.(2021).The brain basis of handwriting deficits in Chinese children with developmental dyslexia.DEVELOPMENTAL SCIENCE,19. |
MLA | Yang, Yang,et al."The brain basis of handwriting deficits in Chinese children with developmental dyslexia".DEVELOPMENTAL SCIENCE (2021):19. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
The brain basis of h(4013KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论