PSYCH OpenIR  > 中国科学院行为科学重点实验室
The brain basis of handwriting deficits in Chinese children with developmental dyslexia
Yang, Yang1,2; Zuo, Zhentao3; Tam, Fred4; Graham, Simon J.4,5; Li, Junjun1,2; Ji, Yuzhu6; Meng, Zelong7; Gu, Chanyuan8; Bi, Hong-Yan1,2; Ou, Jian9; Xu, Min9,10
First AuthorYangYang
Correspondent Emailxumin@szu.edu.cn
Contribution Rank1
Abstract

Abundant behavioral studies have demonstrated high comorbidity of reading and handwriting difficulties in developmental dyslexia (DD), a neurological condition characterized by unexpectedly low reading ability despite adequate nonverbal intelligence and typical schooling. The neural correlates of handwriting deficits remain largely unknown; however, as well as the extent that handwriting deficits share common neural bases with reading deficits in DD. The present work used functional magnetic resonance imaging to examine brain activity during handwriting and reading tasks in Chinese dyslexic children (n = 18) and age-matched controls (n = 23). Compared to controls, dyslexic children exhibited reduced activation during handwriting tasks in brain regions supporting sensory-motor processing (including supplementary motor area and postcentral gyrus) and visual-orthography processing (including bilateral precuneus and right cuneus). Among these regions, the left supplementary motor area and the right precuneus also showed a trend of reduced activation during reading tasks in dyslexics. Moreover, increased activation was found in the left inferior frontal gyrus and anterior cingulate cortex in dyslexics, which may reflect more efforts of executive control to compensate for the impairments of motor and visual-orthographic processing. Finally, dyslexic children exhibited aberrant functional connectivity among brain areas for cognitive control and sensory-motor processes during handwriting tasks. Together, these findings suggest that handwriting deficits in DD are associated with functional abnormalities of multiple brain regions implicated in motor execution, visual-orthographic processing, and cognitive control, providing important implications for the diagnosis and treatment of dyslexia.

Keywordbrain activation developmental dyslexia fMRI functional connectivity handwriting reading
2021-08-06
Language英语
DOI10.1111/desc.13161
Source PublicationDEVELOPMENTAL SCIENCE
ISSN1363-755X
Pages19
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31800954] ; National Natural Science Foundation of China[31700951] ; Shenzhen Basic Research Grant[JCYJ20170412164259361] ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions[2021SHIBS0003] ; Guangdong Key Basic Research Grant[2018B030332001]
PublisherWILEY
WOS KeywordIMPLICIT LEARNING-DEFICITS ; ANTERIOR CINGULATE CORTEX ; FMRI CONNECTIVITY ; COLLEGE-STUDENTS ; WHOLE-BRAIN ; MOTOR ; CHARACTERS ; SYSTEM ; SKILLS ; SUPPLEMENTARY
WOS Research AreaPsychology
WOS SubjectPsychology, Developmental ; Psychology, Experimental
WOS IDWOS:000681614600001
Funding OrganizationNational Natural Science Foundation of China ; Shenzhen Basic Research Grant ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions ; Guangdong Key Basic Research Grant
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40052
Collection中国科学院行为科学重点实验室
Corresponding AuthorXu, Min
Affiliation1.Chinese Acad Sci, Inst Psychol, Ctr Brain Sci & Learning Difficulties, CAS Key Lab Behav Sci, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China
4.Sunnybrook Res Inst, Phys Sci Platform, Toronto, ON, Canada
5.Univ Toronto, Dept Med Biophys, Toronto, ON, Canada
6.Zhejiang Univ Technol, Dept Psychol, Coll Educ, Hangzhou, Peoples R China
7.Beijing Forestry Univ, Sch Humanities & Social Sci, Dept Psychol, Beijing, Peoples R China
8.Hong Kong Polytech Univ, Fac Humanities, Dept Chinese & Bilingual Studies, Hong Kong, Peoples R China
9.Shenzhen Univ, Ctr Brain Disorders & Cognit Sci, 3688 Nanhai Ave, Shenzhen 518060, Peoples R China
10.Shenzhen Inst Neurosci, Ctr Language & Brain, Shenzhen, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yang,Zuo, Zhentao,Tam, Fred,et al. The brain basis of handwriting deficits in Chinese children with developmental dyslexia[J]. DEVELOPMENTAL SCIENCE,2021:19.
APA Yang, Yang.,Zuo, Zhentao.,Tam, Fred.,Graham, Simon J..,Li, Junjun.,...&Xu, Min.(2021).The brain basis of handwriting deficits in Chinese children with developmental dyslexia.DEVELOPMENTAL SCIENCE,19.
MLA Yang, Yang,et al."The brain basis of handwriting deficits in Chinese children with developmental dyslexia".DEVELOPMENTAL SCIENCE (2021):19.
Files in This Item:
File Name/Size DocType Version Access License
The brain basis of h(4013KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Yang]'s Articles
[Zuo, Zhentao]'s Articles
[Tam, Fred]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Yang]'s Articles
[Zuo, Zhentao]'s Articles
[Tam, Fred]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Yang]'s Articles
[Zuo, Zhentao]'s Articles
[Tam, Fred]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.