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Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder | |
Dong, Rui1; Haque, Anam2; Wu, Hanjing Emily2; Placide, John2; Yu, Liling1; Zhang, Xiangyang3,4 | |
第一作者 | Dong, Rui |
通讯作者邮箱 | liling07@ccmu.edu.cn (l. yu) ; zhangxy@psych.ac.cn (x. zhang) |
心理所单位排序 | 3 |
摘要 | Background: Glucose metabolism is related to depression, but the relationship between blood glucose and suicide attempts in patients with major depressive disorder (MDD) remains unclear. This large-scale sample explores the relationship between suicide attempts and fasting blood glucose, in addition to sex differences in first-episode and drug naive (FEDN) MDD patients. Methods: 1718 FEDN MDD patients diagnosed for the first time were recruited, and their demographic data, clinical data, and blood glucose indicators were collected. 17-item Hamilton Depression Rating Scale (HAMD), 14-item Hamilton Anxiety Rating Scale (HAMA), and positive subscale of the Positive and Negative Syndrome Scale (PANSS) were used to assess their depression, anxiety and psychotic symptoms, respectively. Results: The depression, anxiety, psychotic symptoms and blood sugar levels of the suicide attempt group were higher than those of the non-suicide attempt group. Correlation analysis showed that blood glucose was significantly associated with suicide attempts in male and female patients. While binary logistic regression showed that blood glucose levels were significantly associated with suicide attempts in male patients, it showed that suicide attempts were not significantly associated with blood glucose levels in female patients. Limitations: The main limitations are cross-sectional design and inability to control selection bias. Conclusions: In male MDD patients, fasting blood glucose level is a potential biomarker of suicide attempt, which deserves attention to avoid suicide risk. However, in female patients, fasting blood glucose has no significant correlation to suicide attempts. |
关键词 | Suicide attempt Blood glucose Major depressive disorder Regression analysis Sex differences |
2021-09-01 | |
DOI | 10.1016/j.jad.2021.05.110 |
发表期刊 | JOURNAL OF AFFECTIVE DISORDERS |
ISSN | 0165-0327 |
卷号 | 292页码:559-564 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | CAS International Cooperation Research Program[153111KYSB20190004] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health ; Social Science Foundation Project of Beijing[18GLB039] |
出版者 | ELSEVIER |
WOS关键词 | GENDER-DIFFERENCES ; RISK-FACTORS ; PHYSICAL ILLNESS ; BRAIN GLUCOSE ; YOUNG-ADULTS ; PREVALENCE ; IDEATION ; HORMONE ; ADOLESCENTS ; HEALTH |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Psychiatry |
WOS记录号 | WOS:000677643500010 |
WOS分区 | Q1 |
资助机构 | CAS International Cooperation Research Program ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health ; Social Science Foundation Project of Beijing |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/40068 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Yu, Liling; Zhang, Xiangyang |
作者单位 | 1.Capital Med Univ, Sch Med Humanities, Dept Med Psychol, Beijing, Peoples R China 2.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Dong, Rui,Haque, Anam,Wu, Hanjing Emily,et al. Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,292:559-564. |
APA | Dong, Rui,Haque, Anam,Wu, Hanjing Emily,Placide, John,Yu, Liling,&Zhang, Xiangyang.(2021).Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,292,559-564. |
MLA | Dong, Rui,et al."Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 292(2021):559-564. |
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