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Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder
Dong, Rui1; Haque, Anam2; Wu, Hanjing Emily2; Placide, John2; Yu, Liling1; Zhang, Xiangyang3,4
第一作者Dong, Rui
通讯作者邮箱liling07@ccmu.edu.cn (l. yu) ; zhangxy@psych.ac.cn (x. zhang)
心理所单位排序3
摘要

Background: Glucose metabolism is related to depression, but the relationship between blood glucose and suicide attempts in patients with major depressive disorder (MDD) remains unclear. This large-scale sample explores the relationship between suicide attempts and fasting blood glucose, in addition to sex differences in first-episode and drug naive (FEDN) MDD patients. Methods: 1718 FEDN MDD patients diagnosed for the first time were recruited, and their demographic data, clinical data, and blood glucose indicators were collected. 17-item Hamilton Depression Rating Scale (HAMD), 14-item Hamilton Anxiety Rating Scale (HAMA), and positive subscale of the Positive and Negative Syndrome Scale (PANSS) were used to assess their depression, anxiety and psychotic symptoms, respectively. Results: The depression, anxiety, psychotic symptoms and blood sugar levels of the suicide attempt group were higher than those of the non-suicide attempt group. Correlation analysis showed that blood glucose was significantly associated with suicide attempts in male and female patients. While binary logistic regression showed that blood glucose levels were significantly associated with suicide attempts in male patients, it showed that suicide attempts were not significantly associated with blood glucose levels in female patients. Limitations: The main limitations are cross-sectional design and inability to control selection bias. Conclusions: In male MDD patients, fasting blood glucose level is a potential biomarker of suicide attempt, which deserves attention to avoid suicide risk. However, in female patients, fasting blood glucose has no significant correlation to suicide attempts.

关键词Suicide attempt Blood glucose Major depressive disorder Regression analysis Sex differences
2021-09-01
DOI10.1016/j.jad.2021.05.110
发表期刊JOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
卷号292页码:559-564
期刊论文类型实证研究
收录类别SCI
资助项目CAS International Cooperation Research Program[153111KYSB20190004] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health ; Social Science Foundation Project of Beijing[18GLB039]
出版者ELSEVIER
WOS关键词GENDER-DIFFERENCES ; RISK-FACTORS ; PHYSICAL ILLNESS ; BRAIN GLUCOSE ; YOUNG-ADULTS ; PREVALENCE ; IDEATION ; HORMONE ; ADOLESCENTS ; HEALTH
WOS研究方向Neurosciences & Neurology ; Psychiatry
WOS类目Clinical Neurology ; Psychiatry
WOS记录号WOS:000677643500010
WOS分区Q1
资助机构CAS International Cooperation Research Program ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health ; Social Science Foundation Project of Beijing
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/40068
专题中国科学院心理健康重点实验室
通讯作者Yu, Liling; Zhang, Xiangyang
作者单位1.Capital Med Univ, Sch Med Humanities, Dept Med Psychol, Beijing, Peoples R China
2.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
通讯作者单位中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
Dong, Rui,Haque, Anam,Wu, Hanjing Emily,et al. Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,292:559-564.
APA Dong, Rui,Haque, Anam,Wu, Hanjing Emily,Placide, John,Yu, Liling,&Zhang, Xiangyang.(2021).Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,292,559-564.
MLA Dong, Rui,et al."Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 292(2021):559-564.
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