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Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder
Dong, Rui1; Haque, Anam2; Wu, Hanjing Emily2; Placide, John2; Yu, Liling1; Zhang, Xiangyang3,4
First AuthorDong, Rui
Correspondent Emailliling07@ccmu.edu.cn (l. yu) ; zhangxy@psych.ac.cn (x. zhang)
Contribution Rank3
Abstract

Background: Glucose metabolism is related to depression, but the relationship between blood glucose and suicide attempts in patients with major depressive disorder (MDD) remains unclear. This large-scale sample explores the relationship between suicide attempts and fasting blood glucose, in addition to sex differences in first-episode and drug naive (FEDN) MDD patients. Methods: 1718 FEDN MDD patients diagnosed for the first time were recruited, and their demographic data, clinical data, and blood glucose indicators were collected. 17-item Hamilton Depression Rating Scale (HAMD), 14-item Hamilton Anxiety Rating Scale (HAMA), and positive subscale of the Positive and Negative Syndrome Scale (PANSS) were used to assess their depression, anxiety and psychotic symptoms, respectively. Results: The depression, anxiety, psychotic symptoms and blood sugar levels of the suicide attempt group were higher than those of the non-suicide attempt group. Correlation analysis showed that blood glucose was significantly associated with suicide attempts in male and female patients. While binary logistic regression showed that blood glucose levels were significantly associated with suicide attempts in male patients, it showed that suicide attempts were not significantly associated with blood glucose levels in female patients. Limitations: The main limitations are cross-sectional design and inability to control selection bias. Conclusions: In male MDD patients, fasting blood glucose level is a potential biomarker of suicide attempt, which deserves attention to avoid suicide risk. However, in female patients, fasting blood glucose has no significant correlation to suicide attempts.

KeywordSuicide attempt Blood glucose Major depressive disorder Regression analysis Sex differences
2021-09-01
DOI10.1016/j.jad.2021.05.110
Source PublicationJOURNAL OF AFFECTIVE DISORDERS
ISSN0165-0327
Volume292Pages:559-564
Subtype实证研究
Indexed BySCI
Funding ProjectCAS International Cooperation Research Program[153111KYSB20190004] ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health ; Social Science Foundation Project of Beijing[18GLB039]
PublisherELSEVIER
WOS KeywordGENDER-DIFFERENCES ; RISK-FACTORS ; PHYSICAL ILLNESS ; BRAIN GLUCOSE ; YOUNG-ADULTS ; PREVALENCE ; IDEATION ; HORMONE ; ADOLESCENTS ; HEALTH
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Psychiatry
WOS IDWOS:000677643500010
WoS QuartileQ1
Funding OrganizationCAS International Cooperation Research Program ; CAS Pioneer Hundred Talents Program ; CAS Key Lab of Mental Health ; Social Science Foundation Project of Beijing
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40068
Collection中国科学院心理健康重点实验室
Corresponding AuthorYu, Liling; Zhang, Xiangyang
Affiliation1.Capital Med Univ, Sch Med Humanities, Dept Med Psychol, Beijing, Peoples R China
2.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Dong, Rui,Haque, Anam,Wu, Hanjing Emily,et al. Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,292:559-564.
APA Dong, Rui,Haque, Anam,Wu, Hanjing Emily,Placide, John,Yu, Liling,&Zhang, Xiangyang.(2021).Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder.JOURNAL OF AFFECTIVE DISORDERS,292,559-564.
MLA Dong, Rui,et al."Sex differences in the association between suicide attempts and glucose disturbances in first-episode and drug naive patients with major depressive disorder".JOURNAL OF AFFECTIVE DISORDERS 292(2021):559-564.
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