PSYCH OpenIR  > 中国科学院心理健康重点实验室
Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis
Ren, Fuxin1,2; Ma, Wen3; Zong, Wei1,2; Li, Ning1,2; Li, Xiao1,2; Li, Fuyan1,2; Wu, Lili4; Li, Honghao5; Li, Muwei6; Gao, Fei1,2
Corresponding AuthorGao, Fei(feigao6262@163.com)
AbstractPresbycusis (PC) is characterized by preferential hearing loss at high frequencies and difficulty in speech recognition in noisy environments. Previous studies have linked PC to cognitive impairment, accelerated cognitive decline and incident Alzheimer's disease. However, the neural mechanisms of cognitive impairment in patients with PC remain unclear. Although resting-state functional magnetic resonance imaging (rs-fMRI) studies have explored low-frequency oscillation (LFO) connectivity or amplitude of PC-related neural activity, it remains unclear whether the abnormalities occur within all frequency bands or within specific frequency bands. Fifty-one PC patients and fifty-one well-matched normal hearing controls participated in this study. The LFO amplitudes were investigated using the amplitude of low-frequency fluctuation (ALFF) at different frequency bands (slow-4 and slow-5). PC patients showed abnormal LFO amplitudes in the Heschl's gyrus, dorsolateral prefrontal cortex (dlPFC), frontal eye field and key nodes of the speech network exclusively in slow-4, which suggested that abnormal spontaneous neural activity in PC was frequency dependent. Our findings also revealed that stronger functional connectivity between the dlPFC and the posterodorsal stream of auditory processing, as well as lower functional coupling between the PCC and key nodes of the DMN, which were associated with cognitive impairments in PC patients. Our study might underlie the cross-modal plasticity and higher-order cognitive participation of the auditory cortex after partial hearing deprivation. Our findings indicate that frequency-specific analysis of ALFF could provide valuable insights into functional alterations in the auditory cortex and non-auditory regions involved in cognitive impairment associated with PC.
Keywordpresbycusis cognitive impairment low-frequency fluctuation frequency band functional connectivity
2021-07-14
Language英语
DOI10.3389/fnagi.2021.649874
Source PublicationFRONTIERS IN AGING NEUROSCIENCE
ISSN1663-4365
Volume13Pages:14
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China for Young Scholars[81601479] ; Taishan Scholars Project[tsqn201812147] ; China Postdoctoral Science Foundation[2017M621089] ; Jinan Science and Technology Development Program of China[201907097] ; Jinan Science and Technology Development Program of China[202019098] ; Shandong Provincial Medical and Healthy Technology Development Program of China[202009010449] ; Academic Promotion Programme of Shandong First Medical University[2019QL023]
PublisherFRONTIERS MEDIA SA
WOS KeywordHEARING-LOSS ; OLDER-ADULTS ; FUNCTIONAL CONNECTIVITY ; WORKING-MEMORY ; MOTOR CORTEX ; PREVALENCE ; NETWORKS ; DEMENTIA ; GYRUS ; ADHD
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000678328100001
Funding OrganizationNational Natural Science Foundation of China for Young Scholars ; Taishan Scholars Project ; China Postdoctoral Science Foundation ; Jinan Science and Technology Development Program of China ; Shandong Provincial Medical and Healthy Technology Development Program of China ; Academic Promotion Programme of Shandong First Medical University
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40077
Collection中国科学院心理健康重点实验室
Corresponding AuthorGao, Fei
Affiliation1.Shandong Univ, Cheeloo Coll Med, Shandong Prov Hosp, Dept Radiol, Jinan, Peoples R China
2.Shandong First Med Univ, Shandong Prov Hosp, Dept Radiol, Jinan, Peoples R China
3.Shandong Univ, Cheeloo Coll Med, Cent Hosp Jinan City, Dept Otolaryngol, Jinan, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Shandong First Med Univ, Shandong Prov Hosp, Dept Neurol, Jinan, Peoples R China
6.Vanderbilt Univ Inst Imaging Sci, Nashville, TN USA
Recommended Citation
GB/T 7714
Ren, Fuxin,Ma, Wen,Zong, Wei,et al. Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis[J]. FRONTIERS IN AGING NEUROSCIENCE,2021,13:14.
APA Ren, Fuxin.,Ma, Wen.,Zong, Wei.,Li, Ning.,Li, Xiao.,...&Gao, Fei.(2021).Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis.FRONTIERS IN AGING NEUROSCIENCE,13,14.
MLA Ren, Fuxin,et al."Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis".FRONTIERS IN AGING NEUROSCIENCE 13(2021):14.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ren, Fuxin]'s Articles
[Ma, Wen]'s Articles
[Zong, Wei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ren, Fuxin]'s Articles
[Ma, Wen]'s Articles
[Zong, Wei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ren, Fuxin]'s Articles
[Ma, Wen]'s Articles
[Zong, Wei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.