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Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia
Hu, Jinghan1; Zhou, Yongjie2; Wang, Ruoxi3; Qi, Ling4; Zhou, Xin5; Song, Xiuli6; Zeng, Lingyun2; Zhang, Xiangyang7
第一作者Jinghan Hu
通讯作者邮箱qingzhu1108@126.com (y. zhou) ; zhangxy@psych.ac.cn (x. zhang)
心理所单位排序7
摘要

Extensive studies have reported alterations in glucose metabolism in adult-onset patients with schizophrenia, but less attention has been paid to adolescent-onset patients with first-episode drug-naive (FEDN) schizophrenia. The purpose of this study was to compare glucose metabolism between adolescent-onset patients with FEDN schizophrenia and healthy controls and to investigate the relationship between glucose metabolism and clinical symptoms in patients with schizophrenia. This study compared the glycometabolism parameters between 51 adolescents-onset patients with FEDN schizophrenia and 51 age- and sex-matched healthy controls. The Chinese version of the Positive and Negative Syndrome Scale (PANSS), Hamilton Anxiety Rating Scale, and Hamilton Depression Rating Scale were used to assess patients' psychiatric, anxiety, and depressive symptoms. The results showed that compared with healthy controls, the patients had a significantly higher prevalence of impaired fasting glucose and insulin resistance, as well as higher fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance index (HOMA-IR) and triglycerides, but lower high-density lipo-protein cholesterol levels. Moreover, HOMA-IR was negatively associated with PANSS general psychopathology, while glucose was positively correlated with depressive symptoms among patients. In sum, adolescent-onset patients with FEDN schizophrenia are more likely to have abnormal glucose metabolism and dyslipidemia than their healthy counterparts. Moreover, abnormal glucose metabolism may be closely related to the psychopathological symptoms of schizophrenia in the early stage of the disease.

关键词Adolescence Schizophrenia Glycometabolism First-episode drug-naive Psychopathology
2021-08-01
DOI10.1016/j.ajp.2021.102716
发表期刊ASIAN JOURNAL OF PSYCHIATRY
ISSN1876-2018
卷号62页码:5
期刊论文类型实证研究
收录类别SCI
出版者ELSEVIER
WOS关键词INSULIN-RESISTANCE ; DISTURBANCES ; METAANALYSIS ; HOMEOSTASIS ; TOLERANCE ; DOPAMINE ; SCALE ; MODEL
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000677477200031
WOS分区Q2
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/40086
专题中国科学院心理健康重点实验室
通讯作者Zhou, Yongjie; Zhang, Xiangyang
作者单位1.City Univ Hong Kong, Dept Social & Behav Sci, Kowloon Tong, Tat Chee Ave, Hong Kong, Peoples R China
2.Shenzhen Kangning Hosp, Dept Psychiat Rehabil, 77 Zhenbi Rd, Shenzhen, Guangdong, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Med & Hlth Management, Wuhan, Peoples R China
4.Wuhan Polytech Univ, Sch Hlth Sci & Nursing, Wuhan, Peoples R China
5.China Univ Geosci, Res Ctr Psychol & Hlth Sci, Wuhan, Peoples R China
6.Binzhou Med Univ, Yantai Affiliated Hosp, Clin Psychol, Yantai, Peoples R China
7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Hu, Jinghan,Zhou, Yongjie,Wang, Ruoxi,et al. Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia[J]. ASIAN JOURNAL OF PSYCHIATRY,2021,62:5.
APA Hu, Jinghan.,Zhou, Yongjie.,Wang, Ruoxi.,Qi, Ling.,Zhou, Xin.,...&Zhang, Xiangyang.(2021).Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia.ASIAN JOURNAL OF PSYCHIATRY,62,5.
MLA Hu, Jinghan,et al."Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia".ASIAN JOURNAL OF PSYCHIATRY 62(2021):5.
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