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Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia
Hu, Jinghan1; Zhou, Yongjie2; Wang, Ruoxi3; Qi, Ling4; Zhou, Xin5; Song, Xiuli6; Zeng, Lingyun2; Zhang, Xiangyang7
Corresponding AuthorZhou, Yongjie(qingzhu1108@126.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
AbstractExtensive studies have reported alterations in glucose metabolism in adult-onset patients with schizophrenia, but less attention has been paid to adolescent-onset patients with first-episode drug-naive (FEDN) schizophrenia. The purpose of this study was to compare glucose metabolism between adolescent-onset patients with FEDN schizophrenia and healthy controls and to investigate the relationship between glucose metabolism and clinical symptoms in patients with schizophrenia. This study compared the glycometabolism parameters between 51 adolescents-onset patients with FEDN schizophrenia and 51 age- and sex-matched healthy controls. The Chinese version of the Positive and Negative Syndrome Scale (PANSS), Hamilton Anxiety Rating Scale, and Hamilton Depression Rating Scale were used to assess patients' psychiatric, anxiety, and depressive symptoms. The results showed that compared with healthy controls, the patients had a significantly higher prevalence of impaired fasting glucose and insulin resistance, as well as higher fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance index (HOMA-IR) and triglycerides, but lower high-density lipo-protein cholesterol levels. Moreover, HOMA-IR was negatively associated with PANSS general psychopathology, while glucose was positively correlated with depressive symptoms among patients. In sum, adolescent-onset patients with FEDN schizophrenia are more likely to have abnormal glucose metabolism and dyslipidemia than their healthy counterparts. Moreover, abnormal glucose metabolism may be closely related to the psychopathological symptoms of schizophrenia in the early stage of the disease.
KeywordAdolescence Schizophrenia Glycometabolism First-episode drug-naive Psychopathology
2021-08-01
Language英语
DOI10.1016/j.ajp.2021.102716
Source PublicationASIAN JOURNAL OF PSYCHIATRY
ISSN1876-2018
Volume62Pages:5
Indexed BySCI
PublisherELSEVIER
WOS KeywordINSULIN-RESISTANCE ; DISTURBANCES ; METAANALYSIS ; HOMEOSTASIS ; TOLERANCE ; DOPAMINE ; SCALE ; MODEL
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000677477200031
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40086
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhou, Yongjie; Zhang, Xiangyang
Affiliation1.City Univ Hong Kong, Dept Social & Behav Sci, Kowloon Tong, Tat Chee Ave, Hong Kong, Peoples R China
2.Shenzhen Kangning Hosp, Dept Psychiat Rehabil, 77 Zhenbi Rd, Shenzhen, Guangdong, Peoples R China
3.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Med & Hlth Management, Wuhan, Peoples R China
4.Wuhan Polytech Univ, Sch Hlth Sci & Nursing, Wuhan, Peoples R China
5.China Univ Geosci, Res Ctr Psychol & Hlth Sci, Wuhan, Peoples R China
6.Binzhou Med Univ, Yantai Affiliated Hosp, Clin Psychol, Yantai, Peoples R China
7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Hu, Jinghan,Zhou, Yongjie,Wang, Ruoxi,et al. Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia[J]. ASIAN JOURNAL OF PSYCHIATRY,2021,62:5.
APA Hu, Jinghan.,Zhou, Yongjie.,Wang, Ruoxi.,Qi, Ling.,Zhou, Xin.,...&Zhang, Xiangyang.(2021).Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia.ASIAN JOURNAL OF PSYCHIATRY,62,5.
MLA Hu, Jinghan,et al."Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia".ASIAN JOURNAL OF PSYCHIATRY 62(2021):5.
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