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Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions
Li, Gen1,2; Cao, Chengqi1,2; Fang, Ruojiao1,2; Liu, Ping3; Luo, Shu3; Liberzon, Israel4; Wang, Li1,2
第一作者Gen Li
通讯作者邮箱wangli1@psych.ac.cn (l. wang)
心理所单位排序1
摘要

Anhedonia is common in individuals with traumatic experience. Anhedonia symptoms play an important role in posttraumatic psychopathology, and are related to various adverse outcomes. The current study is a preliminary neuroimaging study of the neural correlates of posttraumatic anhedonia symptoms. Resting-state fMRI data were acquired from 88 Chinese earthquake survivors. Whole brain analyses and exploratory ROI-to-ROI analyses were performed to examine the relationship between posttraumatic anhedonia symptoms and resting-state functional connectivity (rsFC) of reward-related subcortical nucleus including nucleus accumbens and ventral pallidum. The rsFC between left ventral pallidum and areas of bilateral posterior cingulate cortex (PCC) and precuneus cortex were found lower in the high posttraumatic anhedonia group, after controlling for sex, age and other posttraumatic stress symptoms. The rsFC between left ventral pallidum and PCC and the rsFC between left ventral pallidum and lateral parietal cortex were significantly lower in the high anhedonia group. Our findings suggest that decreased functional connectivity between the ventral pallidum and the brain default mode network (DMN) regions could be the neural correlates of posttraumatic anhedonia symptoms.

关键词Anhedonia Traumatic stress Resting-state fMRI Ventral pallidum Default mode network
2021-08-01
语种英语
DOI10.1016/j.jpsychires.2021.05.061
发表期刊JOURNAL OF PSYCHIATRIC RESEARCH
ISSN0022-3956
卷号140页码:30-34
期刊论文类型实证研究
收录类别SCI
资助项目National Natural Science Foundation of China[31471004] ; National Natural Science Foundation of China[31971020] ; Key Project of the National Social Science Foundation of China[20ZDA079] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; Key Research Program of the Chinese Academy of Sciences[ZDRW-XH-2019-4]
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词STRESS-DISORDER ; EPIDEMIOLOGIC SAMPLE ; REWARD ; PTSD ; PATTERNS ; DEPRESSION ; VETERANS ; ANATOMY ; ROLES ; WOMEN
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000677477100005
资助机构National Natural Science Foundation of China ; Key Project of the National Social Science Foundation of China ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education ; Key Research Program of the Chinese Academy of Sciences
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/40090
专题中国科学院心理健康重点实验室
通讯作者Wang, Li
作者单位1.Inst Psychol, Lab Traumat Stress Studies, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Peoples Hosp Deyang City, Deyang, Sichuan, Peoples R China
4.Univ Texas A&M Univ, Hlth Sci Ctr, Dept Psychiat, Bryan, TX USA
推荐引用方式
GB/T 7714
Li, Gen,Cao, Chengqi,Fang, Ruojiao,et al. Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2021,140:30-34.
APA Li, Gen.,Cao, Chengqi.,Fang, Ruojiao.,Liu, Ping.,Luo, Shu.,...&Wang, Li.(2021).Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions.JOURNAL OF PSYCHIATRIC RESEARCH,140,30-34.
MLA Li, Gen,et al."Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions".JOURNAL OF PSYCHIATRIC RESEARCH 140(2021):30-34.
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