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Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions | |
Li, Gen1,2; Cao, Chengqi1,2; Fang, Ruojiao1,2; Liu, Ping3; Luo, Shu3; Liberzon, Israel4; Wang, Li1,2 | |
第一作者 | Gen Li |
通讯作者邮箱 | wangli1@psych.ac.cn (l. wang) |
心理所单位排序 | 1 |
摘要 | Anhedonia is common in individuals with traumatic experience. Anhedonia symptoms play an important role in posttraumatic psychopathology, and are related to various adverse outcomes. The current study is a preliminary neuroimaging study of the neural correlates of posttraumatic anhedonia symptoms. Resting-state fMRI data were acquired from 88 Chinese earthquake survivors. Whole brain analyses and exploratory ROI-to-ROI analyses were performed to examine the relationship between posttraumatic anhedonia symptoms and resting-state functional connectivity (rsFC) of reward-related subcortical nucleus including nucleus accumbens and ventral pallidum. The rsFC between left ventral pallidum and areas of bilateral posterior cingulate cortex (PCC) and precuneus cortex were found lower in the high posttraumatic anhedonia group, after controlling for sex, age and other posttraumatic stress symptoms. The rsFC between left ventral pallidum and PCC and the rsFC between left ventral pallidum and lateral parietal cortex were significantly lower in the high anhedonia group. Our findings suggest that decreased functional connectivity between the ventral pallidum and the brain default mode network (DMN) regions could be the neural correlates of posttraumatic anhedonia symptoms. |
关键词 | Anhedonia Traumatic stress Resting-state fMRI Ventral pallidum Default mode network |
2021-08-01 | |
语种 | 英语 |
DOI | 10.1016/j.jpsychires.2021.05.061 |
发表期刊 | JOURNAL OF PSYCHIATRIC RESEARCH |
ISSN | 0022-3956 |
卷号 | 140页码:30-34 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[31471004] ; National Natural Science Foundation of China[31971020] ; Key Project of the National Social Science Foundation of China[20ZDA079] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; Key Research Program of the Chinese Academy of Sciences[ZDRW-XH-2019-4] |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS关键词 | STRESS-DISORDER ; EPIDEMIOLOGIC SAMPLE ; REWARD ; PTSD ; PATTERNS ; DEPRESSION ; VETERANS ; ANATOMY ; ROLES ; WOMEN |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000677477100005 |
资助机构 | National Natural Science Foundation of China ; Key Project of the National Social Science Foundation of China ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education ; Key Research Program of the Chinese Academy of Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/40090 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wang, Li |
作者单位 | 1.Inst Psychol, Lab Traumat Stress Studies, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Peoples Hosp Deyang City, Deyang, Sichuan, Peoples R China 4.Univ Texas A&M Univ, Hlth Sci Ctr, Dept Psychiat, Bryan, TX USA |
推荐引用方式 GB/T 7714 | Li, Gen,Cao, Chengqi,Fang, Ruojiao,et al. Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2021,140:30-34. |
APA | Li, Gen.,Cao, Chengqi.,Fang, Ruojiao.,Liu, Ping.,Luo, Shu.,...&Wang, Li.(2021).Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions.JOURNAL OF PSYCHIATRIC RESEARCH,140,30-34. |
MLA | Li, Gen,et al."Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions".JOURNAL OF PSYCHIATRIC RESEARCH 140(2021):30-34. |
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