PSYCH OpenIR  > 中国科学院心理健康重点实验室
Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions
Li, Gen1,2; Cao, Chengqi1,2; Fang, Ruojiao1,2; Liu, Ping3; Luo, Shu3; Liberzon, Israel4; Wang, Li1,2
Corresponding AuthorWang, Li(wangli1@psych.ac.cn)
AbstractAnhedonia is common in individuals with traumatic experience. Anhedonia symptoms play an important role in posttraumatic psychopathology, and are related to various adverse outcomes. The current study is a preliminary neuroimaging study of the neural correlates of posttraumatic anhedonia symptoms. Resting-state fMRI data were acquired from 88 Chinese earthquake survivors. Whole brain analyses and exploratory ROI-to-ROI analyses were performed to examine the relationship between posttraumatic anhedonia symptoms and resting-state functional connectivity (rsFC) of reward-related subcortical nucleus including nucleus accumbens and ventral pallidum. The rsFC between left ventral pallidum and areas of bilateral posterior cingulate cortex (PCC) and precuneus cortex were found lower in the high posttraumatic anhedonia group, after controlling for sex, age and other posttraumatic stress symptoms. The rsFC between left ventral pallidum and PCC and the rsFC between left ventral pallidum and lateral parietal cortex were significantly lower in the high anhedonia group. Our findings suggest that decreased functional connectivity between the ventral pallidum and the brain default mode network (DMN) regions could be the neural correlates of posttraumatic anhedonia symptoms.
KeywordAnhedonia Traumatic stress Resting-state fMRI Ventral pallidum Default mode network
2021-08-01
Language英语
DOI10.1016/j.jpsychires.2021.05.061
Source PublicationJOURNAL OF PSYCHIATRIC RESEARCH
ISSN0022-3956
Volume140Pages:30-34
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31471004] ; National Natural Science Foundation of China[31971020] ; Key Project of the National Social Science Foundation of China[20ZDA079] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; Key Research Program of the Chinese Academy of Sciences[ZDRW-XH-2019-4]
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordSTRESS-DISORDER ; EPIDEMIOLOGIC SAMPLE ; REWARD ; PTSD ; PATTERNS ; DEPRESSION ; VETERANS ; ANATOMY ; ROLES ; WOMEN
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000677477100005
Funding OrganizationNational Natural Science Foundation of China ; Key Project of the National Social Science Foundation of China ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education ; Key Research Program of the Chinese Academy of Sciences
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40090
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Li
Affiliation1.Inst Psychol, Lab Traumat Stress Studies, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Peoples Hosp Deyang City, Deyang, Sichuan, Peoples R China
4.Univ Texas A&M Univ, Hlth Sci Ctr, Dept Psychiat, Bryan, TX USA
Recommended Citation
GB/T 7714
Li, Gen,Cao, Chengqi,Fang, Ruojiao,et al. Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2021,140:30-34.
APA Li, Gen.,Cao, Chengqi.,Fang, Ruojiao.,Liu, Ping.,Luo, Shu.,...&Wang, Li.(2021).Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions.JOURNAL OF PSYCHIATRIC RESEARCH,140,30-34.
MLA Li, Gen,et al."Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions".JOURNAL OF PSYCHIATRIC RESEARCH 140(2021):30-34.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Gen]'s Articles
[Cao, Chengqi]'s Articles
[Fang, Ruojiao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Gen]'s Articles
[Cao, Chengqi]'s Articles
[Fang, Ruojiao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Gen]'s Articles
[Cao, Chengqi]'s Articles
[Fang, Ruojiao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.