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Hypostability in the default mode network and hyperstability in the frontoparietal control network of dynamic functional architecture during rumination
Chen, Xiao1,2,3,4; Yan, Chao-Gan1,2,3,4
Abstract

The neural underpinnings of rumination can be characterized by its specific dynamic nature. Temporal stability is the stable and consistent representation of information by a distributed neural activity and connectivity pattern across brain regions. Although stability is a key feature of the brain's functional architecture, its profiles supporting rumination remain elusive. We characterized the stability of the whole-brain functional architecture during an induced, continuous rumination state and compared it with a well-constrained distraction state as the control condition in a group of healthy participants ( N = 40). We further examined the relationship between stability in regions showing a significant effect on the rumination vs. distraction contrast and rumination traits. The variability of dynamic functional connectivities (FCs) among these regions was also explored to determine the potential coupling regions that drove the altered stability pattern during rumination. The results showed that rumination was characterized by a similar but altered stability profile compared with distraction and resting states. Comparison between rumination and distraction revealed that key regions of the default mode network (DMN), such as the medial prefrontal cortex (MPFC) and bilateral parahippocampal gyrus (PHG), which showed decreased stability while frontoparietal control network (FPCN) regions, including the inferior parietal lobule (IPL) and dorsal lateral prefrontal cortex (DLPFC), showed significantly enhanced stability in rumination compared with distraction. Additionally, stability in the MPFC and IPL was related to individual differences in rumination traits. Exploratory analysis of the variation in dynamic FCs suggested that higher stability in the IPL may be related to its less variable FCs with the PHG. Together, these findings implicated that rumination may be supported by the dissociated dynamic nature of hypostability in the DMN and hyperstability in the FPCN.

KeywordDynamic functional connectivity Default mode network Frontoparietal control network Fluctuation Functional MRI Rumination
2021-11-01
Language英语
DOI10.1016/j.neuroimage.2021.118427
Source PublicationNEUROIMAGE
ISSN1053-8119
Volume241Pages:10
Indexed BySCI
Funding ProjectNational Key R&D Program of China[2017YFC1309902] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81630031] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505] ; Key Research Program of the Chinese Academy of Sciences[ZDBS-SSW-JSC006] ; Beijing Nova Program of Science and Technology[Z191100001119104] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y9CX422005] ; China Postdoctoral Science Foundation[2019M660847] ; China National Postdoctoral Program for Innovative Talents[BX20200360]
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
WOS KeywordRESTING-STATE CONNECTIVITY ; MEDIAL PREFRONTAL CORTEX ; DEPRESSIVE RUMINATION ; BRAIN ; ASSOCIATION ; RESPONSES ; DURATION ; SEGMENTATION ; ACCURATE ; FAILURE
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000693362200007
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China National Postdoctoral Program for Innovative Talents
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40228
Collection中国科学院行为科学重点实验室
Corresponding AuthorYan, Chao-Gan
Affiliation1.Chinese Acad Sci, CAS Key Lab Behav Sci, Inst Psychol, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Int Big Data Ctr Depress Res, Inst Psychol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing 100101, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xiao,Yan, Chao-Gan. Hypostability in the default mode network and hyperstability in the frontoparietal control network of dynamic functional architecture during rumination[J]. NEUROIMAGE,2021,241:10.
APA Chen, Xiao,&Yan, Chao-Gan.(2021).Hypostability in the default mode network and hyperstability in the frontoparietal control network of dynamic functional architecture during rumination.NEUROIMAGE,241,10.
MLA Chen, Xiao,et al."Hypostability in the default mode network and hyperstability in the frontoparietal control network of dynamic functional architecture during rumination".NEUROIMAGE 241(2021):10.
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