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Altered topographical organization of grey matter structural network in early-onset schizophrenia | |
Zhou, Han-Yu1,2; Shi, Li-Juan1,3; Shen, Yan-Mei4; Fang, Yu-Min4; He, Yu-Qiong4; Li, Hua-Bing5; Luo, Xue-Rong4; Cheung, Eric F. C.6; Chan, Raymond C. K.1,2 | |
第一作者 | Zhou, Han-Yu |
通讯作者邮箱 | rckchan@psych.ac.cn (r.c.k. chan) |
心理所单位排序 | 1 |
摘要 | Schizophrenia is characterized by both disrupted neurodevelopmental processes and abnormal brain connectivity. However, few studies have examined the atypical features of brain network topography associated with schizophrenia during childhood and adolescence. We used graph theory to compare the grey matter structural networks of individuals (aged 10-15 years) with early-onset schizophrenia (EOS) (n = 25) and a typicallydeveloping (TD) comparison group (n = 31). Compared with the TD group, EOS patients showed significantly increased clustering and local efficiency across a range of network densities (0.3 - 0.4). The network of EOS patients also had more modules (6 modules in EOS vs. 3 modules in controls), indicating a more segregated network at the cost of functional integration. Although our results were preliminary and failed to survive corrections for multiple comparisons, EOS patients might be characterized by altered nodal centrality in several higher-order associative regions including the prefrontal cortex, the hippocampus and the cerebellum. The EOS structural network also lacked the typical left-hemispheric-dominant hub distribution compared with the TD group. These findings suggest that brain structural network was not only globally but also regionally altered in EOS patients. |
关键词 | Early-onset schizophrenia Structural network Grey matter Graph theory |
2021-10-30 | |
语种 | 英语 |
DOI | 10.1016/j.pscychresns.2021.111344 |
发表期刊 | PSYCHIATRY RESEARCH-NEUROIMAGING |
ISSN | 0925-4927 |
卷号 | 316页码:9 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | National Key Research and Development Programme[2016YFC0906402] ; China Postdoctoral Science Foundation[2016M601157] ; Humanity and Social Science Youth foundation of the Ministry of Education[17YJC190022] ; CAS Key Laboratory of Mental Health, Institute of Psychology |
出版者 | ELSEVIER IRELAND LTD |
WOS关键词 | SMALL-WORLD NETWORKS ; WHITE-MATTER ; COMMUNITY STRUCTURE ; FUNCTIONAL CONNECTIVITY ; BRAIN NETWORKS ; ABNORMALITIES ; ADOLESCENTS ; DISORDERS ; DISCOVERY ; SYMPTOMS |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
WOS类目 | Clinical Neurology ; Neuroimaging ; Psychiatry |
WOS记录号 | WOS:000701718900002 |
WOS分区 | Q3 |
资助机构 | National Key Research and Development Programme ; China Postdoctoral Science Foundation ; Humanity and Social Science Youth foundation of the Ministry of Education ; CAS Key Laboratory of Mental Health, Institute of Psychology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/40305 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K. |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Hunan Univ Sci & Technol, Sch Educ, Xiangtan, Hunan, Peoples R China 4.Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China 5.Cent South Univ, Xiangya Hosp 2, Med Imaging Dept, Changsha, Hunan, Peoples R China 6.Castle Peak Hosp, Hong Kong, Peoples R China |
第一作者单位 | 认知与发展心理学研究室 |
通讯作者单位 | 认知与发展心理学研究室 |
推荐引用方式 GB/T 7714 | Zhou, Han-Yu,Shi, Li-Juan,Shen, Yan-Mei,et al. Altered topographical organization of grey matter structural network in early-onset schizophrenia[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2021,316:9. |
APA | Zhou, Han-Yu.,Shi, Li-Juan.,Shen, Yan-Mei.,Fang, Yu-Min.,He, Yu-Qiong.,...&Chan, Raymond C. K..(2021).Altered topographical organization of grey matter structural network in early-onset schizophrenia.PSYCHIATRY RESEARCH-NEUROIMAGING,316,9. |
MLA | Zhou, Han-Yu,et al."Altered topographical organization of grey matter structural network in early-onset schizophrenia".PSYCHIATRY RESEARCH-NEUROIMAGING 316(2021):9. |
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