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Altered topographical organization of grey matter structural network in early-onset schizophrenia
Zhou, Han-Yu1,2; Shi, Li-Juan1,3; Shen, Yan-Mei4; Fang, Yu-Min4; He, Yu-Qiong4; Li, Hua-Bing5; Luo, Xue-Rong4; Cheung, Eric F. C.6; Chan, Raymond C. K.1,2
First AuthorZhou, Han-Yu
Correspondent Emailrckchan@psych.ac.cn (r.c.k. chan)
Contribution Rank1
Abstract

Schizophrenia is characterized by both disrupted neurodevelopmental processes and abnormal brain connectivity. However, few studies have examined the atypical features of brain network topography associated with schizophrenia during childhood and adolescence. We used graph theory to compare the grey matter structural networks of individuals (aged 10-15 years) with early-onset schizophrenia (EOS) (n = 25) and a typicallydeveloping (TD) comparison group (n = 31). Compared with the TD group, EOS patients showed significantly increased clustering and local efficiency across a range of network densities (0.3 - 0.4). The network of EOS patients also had more modules (6 modules in EOS vs. 3 modules in controls), indicating a more segregated network at the cost of functional integration. Although our results were preliminary and failed to survive corrections for multiple comparisons, EOS patients might be characterized by altered nodal centrality in several higher-order associative regions including the prefrontal cortex, the hippocampus and the cerebellum. The EOS structural network also lacked the typical left-hemispheric-dominant hub distribution compared with the TD group. These findings suggest that brain structural network was not only globally but also regionally altered in EOS patients.

KeywordEarly-onset schizophrenia Structural network Grey matter Graph theory
2021-10-30
Language英语
DOI10.1016/j.pscychresns.2021.111344
Source PublicationPSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
Volume316Pages:9
Subtype实证研究
Indexed BySCI
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; China Postdoctoral Science Foundation[2016M601157] ; Humanity and Social Science Youth foundation of the Ministry of Education[17YJC190022] ; CAS Key Laboratory of Mental Health, Institute of Psychology
PublisherELSEVIER IRELAND LTD
WOS KeywordSMALL-WORLD NETWORKS ; WHITE-MATTER ; COMMUNITY STRUCTURE ; FUNCTIONAL CONNECTIVITY ; BRAIN NETWORKS ; ABNORMALITIES ; ADOLESCENTS ; DISORDERS ; DISCOVERY ; SYMPTOMS
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Neuroimaging ; Psychiatry
WOS IDWOS:000701718900002
WoS QuartileQ3
Funding OrganizationNational Key Research and Development Programme ; China Postdoctoral Science Foundation ; Humanity and Social Science Youth foundation of the Ministry of Education ; CAS Key Laboratory of Mental Health, Institute of Psychology
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40305
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Hunan Univ Sci & Technol, Sch Educ, Xiangtan, Hunan, Peoples R China
4.Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China
5.Cent South Univ, Xiangya Hosp 2, Med Imaging Dept, Changsha, Hunan, Peoples R China
6.Castle Peak Hosp, Hong Kong, Peoples R China
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Zhou, Han-Yu,Shi, Li-Juan,Shen, Yan-Mei,et al. Altered topographical organization of grey matter structural network in early-onset schizophrenia[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2021,316:9.
APA Zhou, Han-Yu.,Shi, Li-Juan.,Shen, Yan-Mei.,Fang, Yu-Min.,He, Yu-Qiong.,...&Chan, Raymond C. K..(2021).Altered topographical organization of grey matter structural network in early-onset schizophrenia.PSYCHIATRY RESEARCH-NEUROIMAGING,316,9.
MLA Zhou, Han-Yu,et al."Altered topographical organization of grey matter structural network in early-onset schizophrenia".PSYCHIATRY RESEARCH-NEUROIMAGING 316(2021):9.
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