Institutional Repository of Key Laboratory of Mental Health, CAS
Association of altered cortical gyrification and psychopathological symptoms in patients with first-episode drug-naive schizophrenia | |
Zhou, Huixia1,2; Wang, Dongmei1,2; Wang, Jiesi1,2; Xu, Hang1,2; Cao, Bo3,4; Zhang, Xiangyang1,2 | |
第一作者 | Zhou, Huixia |
通讯作者邮箱 | zhangxy@psych.ac.cn (x. zhang) |
心理所单位排序 | 1 |
摘要 | Altered brain gyrification in diverse cortical regions has been reported in patients with schizophrenia, which possibly reflects deviations in early neurodevelopment. The main purpose of this study was to examine the relationship between clinical symptoms and abnormal cortical gyrification in drug-naive patients with schizophrenia in a Chinese Han population. We calculated the whole-brain cortical gyrification of 41 patients with first-episode drug-naive schizophrenia and 30 age- and sex-matched healthy controls. The Positive and Negative Syndrome Scale (PANSS) was used to evaluate the psychopathology of patients with schizophrenia. Our results showed that compared to healthy controls, patients had higher cortical gyrification in the left lateral occipital cortex, but lower cortical gyrification in the left transverse temporal cortex. Moreover, the cortical gyrification in the left entorhinal cortex and left fusiform were both positively correlated with the general psychopathology of PANSS. Our findings indicate that abnormal cortical gyrification has occurred in the early stage of schizophrenia, suggesting that abnormal cortical gyrification may play an important role in the pathogenesis and symptomatology of schizophrenia. |
关键词 | Cortical gyrification First-episode drug-naive schizophrenia Clinical symptoms Positive and negative syndrome scale |
2021-10-01 | |
DOI | 10.1016/j.ajp.2021.102749 |
发表期刊 | ASIAN JOURNAL OF PSYCHIATRY |
ISSN | 1876-2018 |
卷号 | 64页码:6 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | CAS International Cooperation Research Program[153111KYSB20190004] ; National Natural Sciences Foundation of China[31900777] |
出版者 | ELSEVIER |
WOS关键词 | PREFRONTAL GYRIFICATION ; CORTEX ; DISORDER ; COMPLEXITY ; RISK ; ABNORMALITIES ; CONNECTIVITY ; THICKNESS ; COGNITION ; UPDATE |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000697027100017 |
WOS分区 | Q2 |
资助机构 | CAS International Cooperation Research Program ; National Natural Sciences Foundation of China |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/40311 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Xiangyang |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB, Canada 4.Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Psychiat & Behav Sci, Houston, TX 77030 USA |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Zhou, Huixia,Wang, Dongmei,Wang, Jiesi,et al. Association of altered cortical gyrification and psychopathological symptoms in patients with first-episode drug-naive schizophrenia[J]. ASIAN JOURNAL OF PSYCHIATRY,2021,64:6. |
APA | Zhou, Huixia,Wang, Dongmei,Wang, Jiesi,Xu, Hang,Cao, Bo,&Zhang, Xiangyang.(2021).Association of altered cortical gyrification and psychopathological symptoms in patients with first-episode drug-naive schizophrenia.ASIAN JOURNAL OF PSYCHIATRY,64,6. |
MLA | Zhou, Huixia,et al."Association of altered cortical gyrification and psychopathological symptoms in patients with first-episode drug-naive schizophrenia".ASIAN JOURNAL OF PSYCHIATRY 64(2021):6. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Association of alter(1049KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论