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Dynamic functional network connectivity associated with post-traumatic stress symptoms in COVID-19 survivors
Fu, Zening1,2,3; Tu, Yiheng1,2; Calhoun, Vince D.3,4,5,6,7; Zhang, Yuqi1,2; Zhao, Qing1,2; Chen, Jun8; Meng, Qingtao9; Lu, Zhijie10; Hu, Li1,2
First AuthorFu, Zening
Correspondent Emailmengqingtao2018@126.com (q. meng) ; lzjwxyz@163.com (z. lu) ; huli@psych.ac.cn (l. hu)
Contribution Rank1
Abstract

Accumulating evidence shows that Coronavirus Disease 19 (COVID-19) survivors may encounter prolonged mental issues, especially post-traumatic stress symptoms (PTSS). Despite manifesting a plethora of behavioral or mental issues in COVID-19 survivors, previous studies illustrated that static brain functional networks of these survivors remain intact. The insignificant results could be due to the conventional statistic network analysis was unable to reveal information that can vary considerably in different temporal scales. In contrast, time-varying characteristics of the dynamic functional networks may help reveal important brain abnormalities in COVID19 survivors. To test this hypothesis, we assessed PTSS and collected functional magnetic resonance imaging (fMRI) with COVID-19 survivors discharged from hospitals and matched controls. Results showed that COVID-19 survivors self-reported a significantly higher PTSS than controls. Tapping into the moment-to-moment variations of the fMRI data, we captured the dynamic functional network connectivity (dFNC) states, and three discriminative reoccurring brain dFNC states were identified. First of all, COVID-19 survivors showed an increased occurrence of a dFNC state with heterogeneous patterns between sensorimotor and visual networks. More importantly, the occurrence rate of this state was significantly correlated with the severity of PTSS. Finally, COVID-19 survivors demonstrated decreased topological organizations in this dFNC state than controls, including the node strength, degree, and local efficiency of the supplementary motor area. To conclude, our findings revealed the altered temporal characteristics of functional networks and their associations with PTSS due to COVID-19. The current results highlight the importance of evaluating dynamic functional network changes with COVID-19 survivors.

KeywordCoronavirus disease 19 (COVID-19) Post-traumatic stress symptoms (PTSS) Functional magnetic resonance imaging (fMRI) Dynamic functional network connectivity (dFNC) Mental health
2021-11-01
DOI10.1016/j.ynstr.2021.100377
Source PublicationNEUROBIOLOGY OF STRESS
ISSN2352-2895
Volume15Pages:10
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[32071061] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E0CX521003] ; Medical Science and Technology Youth Cultivation Project of PLA[21QNPY061] ; National Institutes of Health (NIH)[R01EB006841] ; National Institutes of Health (NIH)[R01EB020407] ; National Institutes of Health (NIH)[P20GM103472]
PublisherELSEVIER SCIENCE INC
WOS KeywordBRAIN ; DEPRESSION ; DISORDER ; ANXIETY
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000702921700007
WoS QuartileQ1
Funding OrganizationNational Natural Science Foundation of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; Medical Science and Technology Youth Cultivation Project of PLA ; National Institutes of Health (NIH)
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40357
Collection中国科学院心理健康重点实验室
中国科学院心理研究所
Corresponding AuthorMeng, Qingtao; Lu, Zhijie; Hu, Li
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
3.Emory Univ, Georgia State Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30322 USA
4.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
5.Georgia State Univ, Dept Psychol, Neurosci Inst, Comp Sci, Univ Plaza, Atlanta, GA 30303 USA
6.Georgia State Univ, Phys, Atlanta, GA 30303 USA
7.Georgia Inst Technol, Dept Elect & Comp Engn, Atlanta, GA 30332 USA
8.Wuhan Univ, Renmin Hosp, Dept Radiol, Wuhan 430060, Peoples R China
9.Wuhan Univ, Renmin Hosp, Dept Anesthesiol, Wuhan 430060, Peoples R China
10.Second Mil Med Univ, Affiliated Hosp 3, Dept Anesthesiol, Shanghai 200438, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Fu, Zening,Tu, Yiheng,Calhoun, Vince D.,et al. Dynamic functional network connectivity associated with post-traumatic stress symptoms in COVID-19 survivors[J]. NEUROBIOLOGY OF STRESS,2021,15:10.
APA Fu, Zening.,Tu, Yiheng.,Calhoun, Vince D..,Zhang, Yuqi.,Zhao, Qing.,...&Hu, Li.(2021).Dynamic functional network connectivity associated with post-traumatic stress symptoms in COVID-19 survivors.NEUROBIOLOGY OF STRESS,15,10.
MLA Fu, Zening,et al."Dynamic functional network connectivity associated with post-traumatic stress symptoms in COVID-19 survivors".NEUROBIOLOGY OF STRESS 15(2021):10.
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