Institutional Repository of Key Laboratory of Behavioral Science, CAS
Gender discrimination facilitates fMRI responses and connectivity to thermal pain | |
Ming Zhang1,2; Yuqi Zhang1,2; Yan Mu1,2; Zhaoxing Wei1,2; Yazhuo Kong1,2,3 | |
第一作者 | Ming Zhang |
其他责任者 | Yazhuo Kong |
通讯作者 | Kong, Yazhuo(kongyz@psych.ac.cn) |
通讯作者邮箱 | kongyz@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Gender discrimination is a serious social issue that has been shown to increase negative consequences, especially in females when accompanied by acute or chronic pain. Experiencing social pain through discrimination can in- crease an individual’s evaluation of evoked physical pain. However, few studies have explored the mechanism un- derlying how gender discrimination modulates brain responses when individuals experience physical pain evoked by noxious stimuli. In this study, we addressed this issue using a gender discrimination fMRI paradigm with ther- mal pain stimulation. We found that discrimination indeed affected participants’ own behavioral self-evaluation of noxious stimuli. Discrimination-encoded brain activations were identified in the temporopolar cortex, while brain activations to thermal stimuli after viewing pictures of discrimination were found in the dorsal anterior cin- gulate cortex (dACC). Brain activations in the temporopolar cortex and the dACC were correlated. Furthermore, pain perception-specific functional connectivity of the dACC-SII in the cue stage and the dACC-frontal in the pain stage were identified, suggesting a facilitative effect of gender discrimination on females’ experience of physical pain. Our results indicate that the dACC may play a central role in mediating the affective aspect of physical pain after experiencing discrimination. These findings provide novel insights into the underlying mechanism of how gender discrimination facilitates females’ experience of physical pain. |
关键词 | Physical pain Gender discrimination Temporopolar dACC PPI |
其他关键词 | Physical pain, Gender discrimination, Temporopolar, dACC, PPI |
2021-10-09 | |
语种 | 英语 |
DOI | 10.1016/j.neuroimage.2021.118644 |
发表期刊 | NeuroImage |
ISSN | 1053-8119 |
卷号 | 244页码:9 |
期刊论文类型 | 实证研究 |
URL | 查看原文 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China[32100861] ; National Natural Science Foundation of China[81871436] ; National Natural Science Foundation of China[82072010] ; National Natural Science Foundation of China[32071016] ; National Natural Science Foundation of China[82030121] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[201900050] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y9CX432005] |
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
WOS关键词 | SOCIAL THREAT ; ROBUST ; EMPATHY ; HEALTH ; OPTIMIZATION ; REGISTRATION ; SENSITIVITY ; PATHWAYS ; ANXIETY ; STIGMA |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000710098200009 |
Q分类 | Q1 |
资助机构 | National Natural Science Foundation of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/40644 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Yazhuo Kong |
作者单位 | 1.CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences 2.Department of Psychology, University of Chinese Academy of Sciences 3.Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, |
第一作者单位 | 中国科学院行为科学重点实验室 |
通讯作者单位 | 中国科学院行为科学重点实验室 |
推荐引用方式 GB/T 7714 | Ming Zhang,Yuqi Zhang,Yan Mu,et al. Gender discrimination facilitates fMRI responses and connectivity to thermal pain[J]. NeuroImage,2021,244:9. |
APA | Ming Zhang,Yuqi Zhang,Yan Mu,Zhaoxing Wei,&Yazhuo Kong.(2021).Gender discrimination facilitates fMRI responses and connectivity to thermal pain.NeuroImage,244,9. |
MLA | Ming Zhang,et al."Gender discrimination facilitates fMRI responses and connectivity to thermal pain".NeuroImage 244(2021):9. |
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