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Gender discrimination facilitates fMRI responses and connectivity to thermal pain
Ming Zhang1,2; Yuqi Zhang1,2; Yan Mu1,2; Zhaoxing Wei1,2; Yazhuo Kong1,2,3
First AuthorMing Zhang
ContributorYazhuo Kong
Corresponding AuthorKong, Yazhuo(kongyz@psych.ac.cn)
Correspondent Emailkongyz@psych.ac.cn
Contribution Rank1
Abstract

Gender discrimination is a serious social issue that has been shown to increase negative consequences, especially in females when accompanied by acute or chronic pain. Experiencing social pain through discrimination can in- crease an individual’s evaluation of evoked physical pain. However, few studies have explored the mechanism un- derlying how gender discrimination modulates brain responses when individuals experience physical pain evoked by noxious stimuli. In this study, we addressed this issue using a gender discrimination fMRI paradigm with ther- mal pain stimulation. We found that discrimination indeed affected participants’ own behavioral self-evaluation of noxious stimuli. Discrimination-encoded brain activations were identified in the temporopolar cortex, while brain activations to thermal stimuli after viewing pictures of discrimination were found in the dorsal anterior cin- gulate cortex (dACC). Brain activations in the temporopolar cortex and the dACC were correlated. Furthermore, pain perception-specific functional connectivity of the dACC-SII in the cue stage and the dACC-frontal in the pain stage were identified, suggesting a facilitative effect of gender discrimination on females’ experience of physical pain. Our results indicate that the dACC may play a central role in mediating the affective aspect of physical pain after experiencing discrimination. These findings provide novel insights into the underlying mechanism of how gender discrimination facilitates females’ experience of physical pain.

KeywordPhysical pain Gender discrimination Temporopolar dACC PPI
Other KeywordsPhysical pain, Gender discrimination, Temporopolar, dACC, PPI
2021-10-09
Language英语
DOI10.1016/j.neuroimage.2021.118644
Source PublicationNeuroImage
ISSN1053-8119
Volume244Pages:9
Subtype实证研究
URL查看原文
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[32100861] ; National Natural Science Foundation of China[81871436] ; National Natural Science Foundation of China[82072010] ; National Natural Science Foundation of China[32071016] ; National Natural Science Foundation of China[82030121] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[201900050] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y9CX432005]
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
WOS KeywordSOCIAL THREAT ; ROBUST ; EMPATHY ; HEALTH ; OPTIMIZATION ; REGISTRATION ; SENSITIVITY ; PATHWAYS ; ANXIETY ; STIGMA
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000710098200009
QuartileQ1
Funding OrganizationNational Natural Science Foundation of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40644
Collection中国科学院行为科学重点实验室
Corresponding AuthorYazhuo Kong
Affiliation1.CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences
2.Department of Psychology, University of Chinese Academy of Sciences
3.Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford,
First Author AffilicationKey Laboratory of Behavioral Science, CAS
Corresponding Author AffilicationKey Laboratory of Behavioral Science, CAS
Recommended Citation
GB/T 7714
Ming Zhang,Yuqi Zhang,Yan Mu,et al. Gender discrimination facilitates fMRI responses and connectivity to thermal pain[J]. NeuroImage,2021,244:9.
APA Ming Zhang,Yuqi Zhang,Yan Mu,Zhaoxing Wei,&Yazhuo Kong.(2021).Gender discrimination facilitates fMRI responses and connectivity to thermal pain.NeuroImage,244,9.
MLA Ming Zhang,et al."Gender discrimination facilitates fMRI responses and connectivity to thermal pain".NeuroImage 244(2021):9.
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