Institutional Repository of Key Laboratory of Mental Health, CAS
Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia | |
Su, Xiuru1; Qiao, Limin2; Liu, Qing3; Shang, Yujie1; Guan, Xiaoni4; Xiu, Meihong4; Zhang, Xiangyang5 | |
第一作者 | Xiuru Su |
通讯作者邮箱 | xiumeihong9797@gmail.com ; zhangxy9@gmail.com |
心理所单位排序 | 5 |
摘要 | Brain-derived neurotrophic factor (BDNF) is reported to be involved in cognitive decline in patients with schizophrenia (SZ). Previous studies have found that cognitive deficits remain stable during the chronic disease phase in SZ, but the findings were inconsistent. The role of BDNF in cognitive deficits at different stage of illness remains unclear. This study aimed to examine the effect of BDNF polymorphisms on cognitive deficits in drug-naive first-episode (DNFE) patients and chronic patients with SZ. 262 DNFE patients, 844 chronic patients, and 1043 healthy controls were recruited to compare 4 polymorphisms in BDNF gene and cognitive function. We found that there was no significant difference in genotype and allele frequencies between SZ patients and controls. However, they were closely related to cognitive functioning. BDNF rs2030324 polymorphism played a strong role in language performance only in DNFE patients with SZ. The language index of DNFE patients with rs2030324 TT and TC genotypes was worse than that of chronic patients, but there was no significant difference in CC genotypes between DNFE and chronic patients. Rs6265 had no significant effect on cognitive functioning in patients and controls. Our result suggests BDNF gene polymorphisms were related to different domains of cognitive function at the different stage of SZ, especially language in DNFE patients. |
2021-10-08 | |
语种 | 英语 |
DOI | 10.1038/s41598-021-99510-7 |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 11期号:1页码:7 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
资助项目 | CAS Pioneer Hundred Talents Program |
出版者 | NATURE PORTFOLIO |
WOS关键词 | NEUROTROPHIC FACTOR ; NEUROCOGNITIVE DEFICITS ; MAJOR DEPRESSION ; HUMAN-MEMORY ; ASSOCIATION ; VOLUME ; EXPRESSION ; HYPOTHESIS ; CLOZAPINE ; VARIANTS |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000705243600077 |
WOS分区 | Q1 |
资助机构 | CAS Pioneer Hundred Talents Program |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/40678 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Xiu, Meihong; Zhang, Xiangyang |
作者单位 | 1.Hebei Prov Vet Hosp, Dept Psychiat, Baoding, Peoples R China 2.Lian Yang Community Hlth Serv Ctr, Shanghai, Peoples R China 3.Qingdao Univ, Qingdao Mental Hlth Ctr, Qingdao, Peoples R China 4.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing 100096, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Su, Xiuru,Qiao, Limin,Liu, Qing,et al. Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia[J]. SCIENTIFIC REPORTS,2021,11(1):7. |
APA | Su, Xiuru.,Qiao, Limin.,Liu, Qing.,Shang, Yujie.,Guan, Xiaoni.,...&Zhang, Xiangyang.(2021).Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia.SCIENTIFIC REPORTS,11(1),7. |
MLA | Su, Xiuru,et al."Genetic polymorphisms of BDNF on cognitive functions in drug-naive first episode patients with schizophrenia".SCIENTIFIC REPORTS 11.1(2021):7. |
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