Institutional Repository of Key Laboratory of Mental Health, CAS
Comprehensive B-Cell Immune Repertoire Analysis of Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis | |
Feng, Jingjing1,2; Fan, Siyuan3; Sun, Yinwei1,2; Ren, Haitao3; Guan, Hongzhi3; Wang, Jing1,2 | |
第一作者 | Jingjing Feng |
通讯作者邮箱 | wangjing@psych.ac.cn (jing wang ) ; guanhz@263.net (guan hongzhi ) |
心理所单位排序 | 1 |
摘要 | Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) and anti-leucine-rich glioma-inactivated 1 encephalitis (anti-LGI1E) are the two most common types of antibody-mediated autoimmune encephalitis. We performed a comprehensive analysis of the B-cell immune repertoire in patients with anti-NMDARE (n = 7) and anti-LGI1E (n = 10) and healthy controls (n = 4). The results revealed the presence of many common clones between patients with these two types of autoimmune encephalitis, which were mostly class-switched. Additionally, many differences were found among the anti-NMDARE, anti-LGI1E, and healthy control groups, including the diversity of the B-cell immune repertoire and gene usage preference. These findings suggest that the same adaptive immune responses occur in patients with anti-NMDARE and anti-LGI1E, which deserves further exploration.
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关键词 | anti-N-methyl-D-aspartate receptor encephalitis anti-leucine-rich glioma-inactivated 1 encephalitis B-cell immune repertoire common clones adaptive immune responses |
2021-10-07 | |
语种 | 英语 |
DOI | 10.3389/fimmu.2021.717598 |
发表期刊 | FRONTIERS IN IMMUNOLOGY |
ISSN | 1664-3224 |
卷号 | 12页码:12 |
期刊论文类型 | 实证研究 |
收录类别 | SCI |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | RECEPTOR ENCEPHALITIS ; ANTIBODIES ; DIAGNOSIS |
WOS研究方向 | Immunology |
WOS类目 | Immunology |
WOS记录号 | WOS:000709961700001 |
WOS分区 | Q1 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/40691 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Guan, Hongzhi; Wang, Jing |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Feng, Jingjing,Fan, Siyuan,Sun, Yinwei,et al. Comprehensive B-Cell Immune Repertoire Analysis of Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis[J]. FRONTIERS IN IMMUNOLOGY,2021,12:12. |
APA | Feng, Jingjing,Fan, Siyuan,Sun, Yinwei,Ren, Haitao,Guan, Hongzhi,&Wang, Jing.(2021).Comprehensive B-Cell Immune Repertoire Analysis of Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis.FRONTIERS IN IMMUNOLOGY,12,12. |
MLA | Feng, Jingjing,et al."Comprehensive B-Cell Immune Repertoire Analysis of Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis".FRONTIERS IN IMMUNOLOGY 12(2021):12. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Comprehensive B-Cell(3361KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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