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Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China.
Deng, Ke; Yue, Ji-Hui; Xu, Jian; Ma, Ping-Ping; Chen, Xiao; Li, Le; Bai, Tong-Jian; Bo, Qi-Jing; Cao, Jun; Chen, Guan-Mao; Chen, Ning-Xuan; Chen, Wei; Cheng, Chang; Cui, Xi-Long; Duan, Jia; Fang, Yi-Ru; Gong, Qi-Yong; Guo, Wen-Bin; Hou, Zheng-Hua; Hu, Lan; Kuang, Li; Li, Feng; Li, Kai-Ming; Li, Tao; Liu, Yan-Song; Liu, Zhe-Ning; Long, Yi-Cheng; Luo, Qing-Hua; Meng, Hua-Qing; Peng, Dai-Hui; Qiu, Hai-Tang; Qiu, Jiang; Shen, Yue-Di; Shi, Yu-Shu; Si, Tian-Mei; Wang, Fei; Wang, Kai; Wang, Li; Wang, Xiang; Wang, Ying; Wu, Xiao-Ping; Wu, Xin-Ran; Xie, Chun-Ming; Xie, Guang-Rong; Xie, Hai-Yan; Xie, Peng; Yang, Hong; Yang, Jian; Yao, Jia-Shu; Yao, Shu-Qiao; Yin, Ying-Ying; Yuan, Yong-Gui; Zhang, Ai-Xia; Zhang, Hong; Zhang, Ke-Rang; Zhang, Lei; Zhang, Zhi-Jun; Zhou, Ru-Bai; Zhou, Yi-Ting; Zhu, Jun-Juan; Zou, Chao-Jie; Zhou, Cong; Zuo, Xi-Nian; Yan, Chao-Gan; Xu, Xiu-Feng; Cheng, Yu-Qi
First AuthorDeng, Ke
Contribution Rank8
Abstract

BACKGROUND: Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. METHODS: In this study, we obtained resting-state functional magnetic resonance imaging (R-fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18-60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel-mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. RESULTS: As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q < .002, z =-7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age-related change in males instead of females. Besides, the reduction of MTG was found to bea male-special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First-episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs.

2021
Language英语
DOI10.1111/bdi.13139
Source PublicationBipolar Disorders
ISSN1399-5618
Subtype实证研究
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40740
Collection中国科学院行为科学重点实验室
Affiliation1.Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
2.Department of Psychiatry, The First Hospital of Jiaxing or The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, 314001, China
3.Department of Psychiatry, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, 519000, China.
4.Research Center of Molecular Imaging, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, 519000, China.
5.Department of Rheumatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
6.Fifth People's Hospital of Zigong City, Zigong, Sichuan, 643020, China.
7.Department of Psychology, University of Chinese Academy of Sciences, Beijing, 100049, China.
8.Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.
9.Anhui Medical University, Hefei, Anhui, 230022, China.
10.Beijing Anding Hospital, Capital Medical University, Beijing, 100054, China.
11.Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
12.The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, China.
13.Department of Psychiatry, Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, China.
14.Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
15.Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, 110001, China.
16.Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, 200240, China.
17.Department of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.
18.Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China.
19.Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210096, China.
20.Mental Health Center, West China Hospital, Sichuan University Chengdu, Sichuan, 610041, China.
21.Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, 215137, China.
22.Faculty of Psychology, Southwest University, Chongqing, 400716, China.
23.Department of Diagnostics, Affiliated Hospital, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, China.
24.Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
25.National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, 100191, China.
26.Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, 100191, China.
27.Xi'an Central Hospital, Xi'an, Shaanxi, 710003, China.
28.Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu, 210009, China.
29.Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
30.Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.
31.Chongqing Key Laboratory of Neurobiology, Chongqing, 400016, China.
32.Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
33.The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, 710061, China.
34.First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
Recommended Citation
GB/T 7714
Deng, Ke,Yue, Ji-Hui,Xu, Jian,et al. Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China.[J]. Bipolar Disorders,2021.
APA Deng, Ke.,Yue, Ji-Hui.,Xu, Jian.,Ma, Ping-Ping.,Chen, Xiao.,...&Cheng, Yu-Qi.(2021).Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China..Bipolar Disorders.
MLA Deng, Ke,et al."Impaired robust interhemispheric function integration of depressive brain from REST-meta-MDD database in China.".Bipolar Disorders (2021).
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