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Brain activities of reconsolidation: nuances in post-retrieval interference led to optimal alterations of episodic memories
Dong-ni Pan1,2,3; Delhii Hoid1,2; Oliver T. Wolf3; Xuebing Li1,2
第一作者Dong-ni Pan
通讯作者Li, Xuebing(lixb@psych.ac.cn)
通讯作者邮箱lixb@psych.ac.cn (x. li)
心理所单位排序1
摘要

When memories are reactivated, they enter a period of instability in which they can be affected by a variety of follow-up manipulations. The existence of this type of memory reconsolidation offers the potential for clinical interventions of maladaptive memory. However, such potential cannot be fully exploited until the internal mechanisms of memory changes via reconsolidation are better understood. In the current study, we used a threeday AB-AC paradigm that included self-referential simulation processing and employed electroencephalogram (EEG) techniques to explore how post-retrieval updates of episodic memory come about. Behaviorally, we found that reactivation alongside interference learning (ReI-L, AB-AC, n = 52) can produce much more false memories compared to no reactivation new learning (New-L, AB-DC, n = 31) and reactivation repetitive learning (Rep-L, AB-AB. n = 30). More importantly, ERP results revealed that trials from ReI-L in which memory distortions subsequently occurred showed an observable (compared to the new-learning without memory reactivation) but attenuated (compared to trials associating with later intact memory) amplitude of frontal N400, indicating a moderate level of early conflict reactivation is necessary to trigger crucial memory instability. In addition, to promote optimal distortion of the original memory, a sufficient later constructional processing is also required, reflecting in these intrusive/later false trials showed a larger amplitude of late posterior negativity (LPN). A linear classifier employing neuro features of FN400 and LPN during the reconsolidation phase could predict the original memory retention with 72% accuracy. The present findings indicate that nuance in post-retrieval interference, moderate conflict with protracted construction can lead to optimal alterations of episodic memories.

关键词Reconsolidation Episodic memory Single-trial ERP False memory Post-retrieval updates
2021-11
语种英语
DOIdoi: 10.1016/j.nlm.2021.107531
发表期刊Neurology of learning and memory
ISSN1074-7427
卷号185页码:9
期刊论文类型实证研究
收录类别SCI
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词LATE POSTERIOR NEGATIVITY ; DECLARATIVE MEMORY ; COMPONENT ; UPDATE ; REACTIVATION ; POTENTIALS ; MECHANISMS ; DYNAMICS ; HUMANS ; TRAUMA
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology ; Psychology
WOS类目Behavioral Sciences ; Neurosciences ; Psychology ; Psychology, Multidisciplinary
WOS记录号WOS:000710198200010
WOS分区Q2
研究方法脑成像
取样对象人类
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/40806
专题中国科学院心理健康重点实验室
通讯作者Dong-ni Pan
作者单位1.Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
2.Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
3.Department of Cognitive Psychology, Institute of Cognitive Neuroscience, Ruhr University Bochum, Bochum 44801, Germany
第一作者单位中国科学院心理研究所
通讯作者单位中国科学院心理研究所
推荐引用方式
GB/T 7714
Dong-ni Pan,Delhii Hoid,Oliver T. Wolf,et al. Brain activities of reconsolidation: nuances in post-retrieval interference led to optimal alterations of episodic memories[J]. Neurology of learning and memory,2021,185:9.
APA Dong-ni Pan,Delhii Hoid,Oliver T. Wolf,&Xuebing Li.(2021).Brain activities of reconsolidation: nuances in post-retrieval interference led to optimal alterations of episodic memories.Neurology of learning and memory,185,9.
MLA Dong-ni Pan,et al."Brain activities of reconsolidation: nuances in post-retrieval interference led to optimal alterations of episodic memories".Neurology of learning and memory 185(2021):9.
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