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Brain activities of reconsolidation: nuances in post-retrieval interference led to optimal alterations of episodic memories
Dong-ni Pan1,2,3; Delhii Hoid1,2; Oliver T. Wolf3; Xuebing Li1,2
First AuthorDong-ni Pan
Corresponding AuthorLi, Xuebing(lixb@psych.ac.cn)
Correspondent Emaillixb@psych.ac.cn (x. li)
Contribution Rank1
Abstract

When memories are reactivated, they enter a period of instability in which they can be affected by a variety of follow-up manipulations. The existence of this type of memory reconsolidation offers the potential for clinical interventions of maladaptive memory. However, such potential cannot be fully exploited until the internal mechanisms of memory changes via reconsolidation are better understood. In the current study, we used a threeday AB-AC paradigm that included self-referential simulation processing and employed electroencephalogram (EEG) techniques to explore how post-retrieval updates of episodic memory come about. Behaviorally, we found that reactivation alongside interference learning (ReI-L, AB-AC, n = 52) can produce much more false memories compared to no reactivation new learning (New-L, AB-DC, n = 31) and reactivation repetitive learning (Rep-L, AB-AB. n = 30). More importantly, ERP results revealed that trials from ReI-L in which memory distortions subsequently occurred showed an observable (compared to the new-learning without memory reactivation) but attenuated (compared to trials associating with later intact memory) amplitude of frontal N400, indicating a moderate level of early conflict reactivation is necessary to trigger crucial memory instability. In addition, to promote optimal distortion of the original memory, a sufficient later constructional processing is also required, reflecting in these intrusive/later false trials showed a larger amplitude of late posterior negativity (LPN). A linear classifier employing neuro features of FN400 and LPN during the reconsolidation phase could predict the original memory retention with 72% accuracy. The present findings indicate that nuance in post-retrieval interference, moderate conflict with protracted construction can lead to optimal alterations of episodic memories.

KeywordReconsolidation Episodic memory Single-trial ERP False memory Post-retrieval updates
2021-11
Language英语
DOIdoi: 10.1016/j.nlm.2021.107531
Source PublicationNeurology of learning and memory
ISSN1074-7427
Volume185Pages:9
Subtype实证研究
Indexed BySCI
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
WOS KeywordLATE POSTERIOR NEGATIVITY ; DECLARATIVE MEMORY ; COMPONENT ; UPDATE ; REACTIVATION ; POTENTIALS ; MECHANISMS ; DYNAMICS ; HUMANS ; TRAUMA
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology ; Psychology
WOS SubjectBehavioral Sciences ; Neurosciences ; Psychology ; Psychology, Multidisciplinary
WOS IDWOS:000710198200010
WoS QuartileQ2
Methodology脑成像
Population人类
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40806
Collection中国科学院心理健康重点实验室
Corresponding AuthorDong-ni Pan
Affiliation1.Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
2.Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China
3.Department of Cognitive Psychology, Institute of Cognitive Neuroscience, Ruhr University Bochum, Bochum 44801, Germany
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Dong-ni Pan,Delhii Hoid,Oliver T. Wolf,et al. Brain activities of reconsolidation: nuances in post-retrieval interference led to optimal alterations of episodic memories[J]. Neurology of learning and memory,2021,185:9.
APA Dong-ni Pan,Delhii Hoid,Oliver T. Wolf,&Xuebing Li.(2021).Brain activities of reconsolidation: nuances in post-retrieval interference led to optimal alterations of episodic memories.Neurology of learning and memory,185,9.
MLA Dong-ni Pan,et al."Brain activities of reconsolidation: nuances in post-retrieval interference led to optimal alterations of episodic memories".Neurology of learning and memory 185(2021):9.
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