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Reducing craving and consumption in individuals with drug addiction, obesity or overeating through neuromodulation intervention: a systematic review and meta-analysis of its follow-up effects
Song, Sensen1; Zilverstand, Anna2; Gui, Wenjun3,4; Pan, Xuefei5; Zhou, Xiaolin1,5,6,7
First AuthorSong, Sensen
Correspondent Emailxz104@pku.edu.cn
Contribution Rank3
Abstract

Background and aims Non-invasive brain stimulation has shown potential in clinical applications aiming at reducing craving and consumption levels in individuals with drug addiction or overeating behaviour. However, it is unclear whether these intervention effects are maintained over time. This study aimed to measure the immediate, short- and long-term effects of excitatory transcranial direct current stimulation (tDCS) and high-frequency repetitive transcranial magnetic stimulation (rTMS) targeting at dorsolateral prefrontal cortex (dlPFC) in people with drug addiction or overeating. Methods A systematic review and random effects meta-analysis. We included 20 articles (total of 22 studies using randomized controlled trials: 3 alcohol dependence, 3 drug dependence, 12 smoking, 4 overeating; total: 720 participants) from January 2000 to June 2020, which reported at least one follow-up assessment of craving, consumption or abstinence levels after the intervention. We compared effects of active versus sham stimulation immediately after the intervention and at the last follow-up assessment, as compared with baseline. Results Excitatory neuromodulation of dlPFC activity reduced craving and consumption immediately after the intervention (craving: g = 0.734, CI = 0.447-1.021, P < 0.001; consumption: g = 0.527, CI = 0.309-0.745; P < 0.001), as well as during short-, mid- and long-term abstinence (craving: g = 0.677, CI = 0.440-0.914, P < 0.001; consumption: g = 0.445, CI = 0.245-0.645, P < 0.001; abstinence levels: g = 0.698, CI = 0.433-0.963, P < 0.001; average time of follow-up: 84 +/- 83 days after last stimulation). Additional analysis demonstrated that the intervention effects were sustained in all populations studied (food, nicotine, alcohol or drug abuse) and with both stimulation techniques used (rTMS, tDCS). Interventions targeting at the left (vs right) hemisphere may be more effective. Conclusions Excitatory neuromodulation targeting the dorsolateral prefrontal cortex appears to lead to a sustained reduction of craving and consumption in individuals with addiction or overeating behaviour.

KeywordAddiction brain stimulation dlPFC eating disorders neuromodulation rTMS tDCS
2021-10-21
DOI10.1111/add.15686
Source PublicationADDICTION
ISSN0965-2140
Pages14
Subtype实证研究
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[71942001] ; National Natural Science Foundation of China[31630034]
PublisherWILEY
WOS KeywordTRANSCRANIAL MAGNETIC STIMULATION ; THETA-BURST-STIMULATION ; PREFRONTAL CORTEX ; SMOKING-CESSATION ; BRAIN-STIMULATION ; FOOD CRAVINGS ; USE DISORDER ; BEHAVIORS ; EFFICACY ; ABUSE
WOS Research AreaSubstance Abuse ; Psychiatry
WOS SubjectSubstance Abuse ; Psychiatry
WOS IDWOS:000710278500001
WoS QuartileQ1
Funding OrganizationNational Natural Science Foundation of China
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40861
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhou, Xiaolin
Affiliation1.Tongji Univ, Sch Humanities, Dept Psychol, Shanghai, Peoples R China
2.Univ Minnesota, Dept Psychiat & Behav Sci, Minneapolis, MN 55455 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Peking Univ, Sch Psychol & Cognit Sci, Beijing 100871, Peoples R China
6.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing, Peoples R China
7.East China Normal Univ, Sch Psychol & Cognit Sci, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Song, Sensen,Zilverstand, Anna,Gui, Wenjun,et al. Reducing craving and consumption in individuals with drug addiction, obesity or overeating through neuromodulation intervention: a systematic review and meta-analysis of its follow-up effects[J]. ADDICTION,2021:14.
APA Song, Sensen,Zilverstand, Anna,Gui, Wenjun,Pan, Xuefei,&Zhou, Xiaolin.(2021).Reducing craving and consumption in individuals with drug addiction, obesity or overeating through neuromodulation intervention: a systematic review and meta-analysis of its follow-up effects.ADDICTION,14.
MLA Song, Sensen,et al."Reducing craving and consumption in individuals with drug addiction, obesity or overeating through neuromodulation intervention: a systematic review and meta-analysis of its follow-up effects".ADDICTION (2021):14.
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