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The past and future of mapping the biomarkers of psychosis
Wang, Ling-Ling1,2; Lui, Simon S. Y.3; Chan, Raymond C. K.1,2
First AuthorWang, Ling-Ling
Correspondent Emailchan, raymond ck (rckchan@psych.ac.cn)
Contribution Rank1
Abstract

Biomarker research has investigated the neurobiological basis for individual differences in liability to psychosis. However, few biomarkers for psychosis have been consistently found to be useful. This paper reviews several previous approaches to identify putative biomarkers of liability to psychosis, and then highlights the lessons that we have learned. We argue that limiting our research to clinical patients at the extreme of the psychosis continuum would likely obscure our knowledge as to how a minority of the general population would develop psychosis. Research on putative neurobiological origins of inter-individual differences in personality traits may be useful in mapping the biomarkers of psychosis. To identify biomarkers applicable to the general population, we advocate the transdiagnostic and psychosis continuum approach. We also advocate the use of multivariate analyses and computational modelling to tackle complex multi-modal datasets. More research should be conducted to study intra-individual variations over different ranges of timescale.

2022-02-01
Language英语
DOI10.1016/j.cobeha.2021.06.007
Source PublicationCURRENT OPINION IN BEHAVIORAL SCIENCES
ISSN2352-1546
Volume43Pages:5
Subtype综述
Indexed BySCI
Funding ProjectCAS Key Laboratory of Mental Health, Institute of Psychology ; Philip KH Wong Foundation
PublisherELSEVIER
WOS KeywordINTRAINDIVIDUAL VARIABILITY ; SCHIZOTYPY ; SCHIZOPHRENIA
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology ; Psychology
WOS SubjectBehavioral Sciences ; Neurosciences ; Psychology, Experimental
WOS IDWOS:000709360200002
WoS QuartileQ1
Funding OrganizationCAS Key Laboratory of Mental Health, Institute of Psychology ; Philip KH Wong Foundation
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/40865
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Wang, Ling-Ling,Lui, Simon S. Y.,Chan, Raymond C. K.. The past and future of mapping the biomarkers of psychosis[J]. CURRENT OPINION IN BEHAVIORAL SCIENCES,2022,43:5.
APA Wang, Ling-Ling,Lui, Simon S. Y.,&Chan, Raymond C. K..(2022).The past and future of mapping the biomarkers of psychosis.CURRENT OPINION IN BEHAVIORAL SCIENCES,43,5.
MLA Wang, Ling-Ling,et al."The past and future of mapping the biomarkers of psychosis".CURRENT OPINION IN BEHAVIORAL SCIENCES 43(2022):5.
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