Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study | |
Kirschner, Matthias1,2; Hodzic-Santor, Benazir1; Antoniades, Mathilde3; Nenadic, Igor4; Kircher, Tilo4; Krug, Axel4,5; Meller, Tina4; Grotegerd, Dominik6; Fornito, Alex7; Arnatkeviciute, Aurina7; Bellgrove, Mark A.7; Tiego, Jeggan7; Dannlowski, Udo6; Koch, Katharina6; Huelsmann, Carina6; Kugel, Harald8; Enneking, Verena6; Klug, Melissa6; Leehr, Elisabeth J.6; Boehnlein, Joscha6; Gruber, Marius6; Mehler, David6; DeRosse, Pamela9,10,11; Moyett, Ashley9; Baune, Bernhard T.6,12; Green, Melissa13,14; Quide, Yann13,14; Pantelis, Christos15; Chan, Raymond16; Wang, Yi16; Ettinger, Ulrich17; Debbane, Martin18; Derome, Melodie18; Gaser, Christian19; Besteher, Bianca19; Diederen, Kelly3; Spencer, Tom J.3; Fletcher, Paul20; Roessler, Wulf21,22,23; Smigielski, Lukasz21; Kumari, Veena24; Premkumar, Preethi24; Park, Haeme R. P.25; Wiebels, Kristina25; Lemmers-Jansen, Imke26; Gilleen, James3,27; Allen, Paul27; Kozhuharova, Petya27; Marsman, Jan-Bernard28; Lebedeva, Irina29; Tomyshev, Alexander29; Mukhorina, Anna29; Kaiser, Stefan30; Fett, Anne-Kathrin3,31; Sommer, Iris28; Schuite-Koops, Sanne28; Paquola, Casey1; Lariviere, Sara1; Bernhardt, Boris1; Dagher, Alain1; Grant, Phillip32; van Erp, Theo G. M.33,34; Turner, Jessica A.35; Thompson, Paul M.36; Aleman, Andre28; Modinos, Gemma3,37 | |
第一作者 | Kirschner, Matthias |
摘要 | Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis. However, a comprehensive neuroanatomical mapping of schizotypy remains to be established. The authors conducted the first large-scale meta-analyses of cortical and subcortical morphometric patterns of schizotypy in healthy individuals, and compared these patterns with neuroanatomical abnormalities observed in major psychiatric disorders. The sample comprised 3004 unmedicated healthy individuals (12-68 years, 46.5% male) from 29 cohorts of the worldwide ENIGMA Schizotypy working group. Cortical and subcortical effect size maps with schizotypy scores were generated using standardized methods. Pattern similarities were assessed between the schizotypy-related cortical and subcortical maps and effect size maps from comparisons of schizophrenia (SZ), bipolar disorder (BD) and major depression (MDD) patients with controls. Thicker right medial orbitofrontal/ventromedial prefrontal cortex (mOFC/vmPFC) was associated with higher schizotypy scores (r = 0.067, p(FDR) = 0.02). The cortical thickness profile in schizotypy was positively correlated with cortical abnormalities in SZ (r = 0.285, p(spin) = 0.024), but not BD (r = 0.166, p(spin) = 0.205) or MDD (r = -0.274, p(spin) = 0.073). The schizotypy-related subcortical volume pattern was negatively correlated with subcortical abnormalities in SZ (rho = -0.690, p(spin) = 0.006), BD (rho = -0.672, p(spin) = 0.009), and MDD (rho = -0.692, p(spin) = 0.004). Comprehensive mapping of schizotypy-related brain morphometry in the general population revealed a significant relationship between higher schizotypy and thicker mOFC/vmPFC, in the absence of confounding effects due to antipsychotic medication or disease chronicity. The cortical pattern similarity between schizotypy and schizophrenia yields new insights into a dimensional neurobiological continuity across the extended psychosis phenotype. |
2021-10-27 | |
DOI | 10.1038/s41380-021-01359-9 |
发表期刊 | MOLECULAR PSYCHIATRY |
ISSN | 1359-4184 |
页码 | 10 |
收录类别 | SCI |
资助项目 | NIH Big Data to Knowledge (BD2K) program under consortium[U54 EB020403] ; Wellcome Trust [Sir Henry Dale Fellowship][202397/Z/16/Z] ; Swiss National Science Foundation[P2SKP3_178175] |
出版者 | SPRINGERNATURE |
WOS关键词 | CLINICAL HIGH-RISK ; STRUCTURAL ABNORMALITIES ; HEALTHY-INDIVIDUALS ; PSYCHOSIS PRONENESS ; CEREBRAL-CORTEX ; BRAIN STRUCTURE ; MATTER CHANGES ; SCHIZOPHRENIA ; THICKNESS ; VOLUME |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry |
WOS类目 | Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry |
WOS记录号 | WOS:000712489500001 |
资助机构 | NIH Big Data to Knowledge (BD2K) program under consortium ; Wellcome Trust [Sir Henry Dale Fellowship] ; Swiss National Science Foundation |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/40868 |
专题 | 健康与遗传心理学研究室 |
通讯作者 | Modinos, Gemma |
作者单位 | 1.McGill Univ, McConnell Brain Imaging Ctr, Montreal Neurol Inst, Montreal, PQ, Canada 2.Univ Zurich, Psychiat Hosp, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland 3.Kings Coll London, Dept Psychosis Studies, London, England 4.Univ Marburg, Marburg, Germany 5.Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany 6.Univ Munster, Dept Psychiat, Munster, Germany 7.Monash Univ, Turner Inst Brain & Mental Hlth, Sch Psychol Sci & Monash Biomed Imaging, Melbourne, Vic, Australia 8.Univ Munster, Univ Clin Radiol, Munster, Germany 9.Northwell Hlth, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA 10.Ctr Psychiat Neurosci, Feinstein Inst Med Res, Manhasset, NY USA 11.Hofstra Northwell, Dept Psychiat, Donald & Barbara Zucker Sch Med, Hempstead, NY USA 12.Univ Melbourne, Melbourne Med Sch, Dept Psychiat, Melbourne, Vic, Australia 13.Univ New South Wales UNSW, Sch Psychiat, Sydney, NSW, Australia 14.Neurosci Res Australia NeuRA, Randwick, NSW, Australia 15.Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia 16.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 17.Univ Bonn, Bonn, Germany 18.Univ Geneva, Geneva, Switzerland 19.Jena Univ Hosp, Jena, Germany 20.Univ Cambridge, Dept Psychiat, Cambridge, England 21.Univ Zurich, Psychiat Univ Hosp Zurich, Zurich, Switzerland 22.Charita Univ Med, Dept Psychiat & Psychotherapy, Berlin, Germany 23.Univ Sao Paulo, Sch Med, Inst Psychiat, Sao Paulo, Brazil 24.Brunel Univ London, Uxbridge, Middx, England 25.Univ Auckland, Sch Psychol, Auckland, New Zealand 26.Free Univ Amsterdam, Amsterdam, Netherlands 27.Univ Roehampton, London, England 28.Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Sci Cells & Syst, Groningen, Netherlands 29.Mental Hlth Res Ctr, Moscow, Russia 30.Geneva Univ Hosp, Dept Psychiat, Geneva, Switzerland 31.City Univ London, London, England 32.Fresenius Univ Appl Sci, Frankfurt, Germany 33.Univ Calif Irvine, Dept Psychiat & Human Behav, Clin Translat Neurosci Lab, Irvine, CA 92717 USA 34.Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA 92717 USA 35.Georgia State Univ, Imaging Genet & Neuroinformat Lab, Atlanta, GA 30303 USA 36.Univ Southern Calif, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Keck Sch Med, Marina, GA USA 37.Kings Coll London, MRC Ctr Neurodev Disorders, London, England |
推荐引用方式 GB/T 7714 | Kirschner, Matthias,Hodzic-Santor, Benazir,Antoniades, Mathilde,et al. Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study[J]. MOLECULAR PSYCHIATRY,2021:10. |
APA | Kirschner, Matthias.,Hodzic-Santor, Benazir.,Antoniades, Mathilde.,Nenadic, Igor.,Kircher, Tilo.,...&Modinos, Gemma.(2021).Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.MOLECULAR PSYCHIATRY,10. |
MLA | Kirschner, Matthias,et al."Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study".MOLECULAR PSYCHIATRY (2021):10. |
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