PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
Alternative TitleThe Roles of Orexins in the Nucleus Accumbens and Ventral Tegmental Area on Rewar d-Associated Behavior Induced by Morphine
白云静; 韩锦; 李勇辉; 黄砚北; 杨晓燕; 隋南
Source Publication心理学报
Keyword条件性位置偏爱 食欲素 中脑腹侧被盖区 伏隔核 OXR1拮抗剂
Subject Area生理心理学/生物心理学
Funding Project国家重点基础研究发展计划(973计划)(2009CB522002,2003CB515404);;中国科学院知识创新工程重要方向项目(KSCXI-TW-R-68);;国家自然科学基金项目(30600184,30770719);;中国科学院“西部之光”人才培养计划“联合学者”项目
NoteOrexins are neuropeptides produced by the hypothalamus.Orexin neurons have extensive projections to the mesolimbic dopamine system(MLSD)and are critically involved in drug addiction.The central nucleus of the MLSD,the ventral tegmental area(VTA)and nucleus accumbens(NAc),contain abundant orexinergic fibers and receptors.In the VTA,orexins are implicated in drug reward-elicited place preference and acquisition of behavioral sensitization.However,less study has been focused on the role of orexins in the NAc in drug reward by now.The present study aims to investigate the roles of orexins in the VTA and NAc in drug reward-associated behavior.The development of conditioned place preference(CPP)induced by morphine was used to investigate the roles of orexins in the VTA and NAc in drug reward.The apparatus for the CPP was consisted of two distinctive compartments.The 135 male Wistar rats were alternatively treated with morphine(3mg/kg)or saline before conditioning training(45min),with one injection per day.Before three conditioning sessions with morphine,the OXR1 antagonist SB334867 was bilaterally microinjected into the VTA(0,1,5μg)or NAcSh(0,1,3 μg).Before two conditioning sessions with morphine,orexin A(0,2,4,6μg)was bilaterally microinjected into the NAcSh.One-way ANOVA and Post Hoc LSD were used to reveal the difference among groups.The results showed that the development of morphine CPP was inhibited when SB334867 was infused into the VTA and not affected when SB334867 was infused into the NAcSh.Orexin A microinjected into the NAcSh did not enhance or inhibit morphine CPP,but increased locomotor activity especially in the rats treated with morphine.The present study demonstrated the different roles of orexins in the VTA and NAcSh in drug reward induced by morphine,indicating that orexins in these two brain regions might regulate the different aspects of addictive behavior.
Document Type期刊论文
Corresponding Author隋南
Recommended Citation
GB/T 7714
白云静,韩锦,李勇辉,等. 伏隔核和中脑腹侧被盖区内食欲素在吗啡奖赏中的作用[J]. 心理学报,2009,41(4):329-336.
APA 白云静,韩锦,李勇辉,黄砚北,杨晓燕,&隋南.(2009).伏隔核和中脑腹侧被盖区内食欲素在吗啡奖赏中的作用.心理学报,41(4),329-336.
MLA 白云静,et al."伏隔核和中脑腹侧被盖区内食欲素在吗啡奖赏中的作用".心理学报 41.4(2009):329-336.
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